Differential role of adrenoceptors in control of plasma glucose and fatty acids in carp, Cyprinus carpio (L.)

G. van den Thillart, G Vianen, M C Ponce, Stefan H. Lelieveld, M. Nieveen, M.J. van Raaij, A Steffens, J Zaagsma

Research output: Contribution to JournalArticleAcademicpeer-review


Carp were cannulated in the dorsal aorta, and after 2 days of recovery they were infused with 1) norepinephrine, 2) yohimbine (alpha(2)-antagonist) plus norepinephrine, 3) clonidine (alpha(2)-agonist), and 4) isoproterenol (nonselective beta-agonist). Norepinephrine lowered the plasma free fatty acid (FFA) level and raised the plasma glucose level for several hours. Norepinephrine in combination with the alpha(2)-antagonist yohimbine resulted in retardation of the FFA decrease, indicating the involvement of alpha(2)-adrenoceptors. Infusion with the partial alpha(2)-agonist clonidine had a smaller effect. Infusion with isoproterenol caused a marked increase of glucose levels, and unexpectedly a decline of plasma FFA levels, indicating a direct involvement of beta-adrenoceptors. Combination of isoproterenol with either atenolol (beta(1)-antagonist) or ICI-118,551 (beta(2)-antagonist) showed that both beta(1)- and beta(2)-adrenoceptors were involved in the glucose release by isoproterenol. Remarkably, the decline of FFA levels was augmented in the presence of ICI-118,551, whereas with atenolol present plasma FFA levels were increased by isoproterenol. Thus it is concluded that in carp both beta(1)- and beta(2)-adrenoceptors mediate glucose release, whereas lipolysis is controlled by inhibitory beta(1)-adrenoceptors and stimulatory beta(2)-adrenoceptors, as well as by inhibitory alpha(2)-adrenoceptors.

Original languageEnglish
Pages (from-to)R615-24
JournalAmerican Journal of Physiology. Regulatory Integrative and Comparative Physiology
Issue number2
Publication statusPublished - Aug 2001


  • Adrenergic Agonists
  • Adrenergic alpha-Agonists
  • Adrenergic alpha-Antagonists
  • Adrenergic beta-Agonists
  • Adrenergic beta-Antagonists
  • Animals
  • Atenolol
  • Blood Glucose
  • Carps
  • Clonidine
  • Epinephrine
  • Fatty Acids, Nonesterified
  • Isoproterenol
  • Lactic Acid
  • Norepinephrine
  • Propanolamines
  • Receptors, Adrenergic, beta
  • Yohimbine
  • Journal Article


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