Diffusion-sensitive Fourier-domain optical coherence tomography

M. Hagen-Eggert, D. Hillmann, P. Koch, G. Hüttmann

Research output: Chapter in Book / Report / Conference proceedingConference contributionAcademicpeer-review

Abstract

Diffusion-sensitive optical coherence tomography (DS-OCT) is presented as a functional extension to OCT. Fluctuations of signal intensity and phase, which are caused by Brownian motion, are analysed by an autocorrelation function similar to dynamic light scattering measurements. Based on an ultra-fast Fourier-domain OCT, DS-OCT can determine quantitatively diffusion properties with high depth resolution, e.g. the hydrodynamic diameter of colloidal suspensions. Performance of DS-OCT is demonstrated with polystyrene particle suspensions and compared to conventional DLS measurements. Applications for DS-OCT may be found in the measurement of particle size distributions of inhomogeneous samples or measurements of diffusion properties at boundary surfaces. Additionally, the method has the capability to become a useful benefit in clinical diagnostics, especially in ophthalmology, where the molecular compositions and pathological changes of anterior eye components could be detected. © 2011 Copyright Society of Photo-Optical Instrumentation Engineers (SPIE).
Original languageEnglish
Title of host publicationOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV
DOIs
Publication statusPublished - 2011
Externally publishedYes
EventOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV - , United States
Duration: 24 Jan 201126 Jan 2011

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422

Conference

ConferenceOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV
Country/TerritoryUnited States
Period24/01/1126/01/11

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