TY - GEN
T1 - Diffusion-sensitive Fourier-domain optical coherence tomography
AU - Hagen-Eggert, M.
AU - Hillmann, D.
AU - Koch, P.
AU - Hüttmann, G.
PY - 2011
Y1 - 2011
N2 - Diffusion-sensitive optical coherence tomography (DS-OCT) is presented as a functional extension to OCT. Fluctuations of signal intensity and phase, which are caused by Brownian motion, are analysed by an autocorrelation function similar to dynamic light scattering measurements. Based on an ultra-fast Fourier-domain OCT, DS-OCT can determine quantitatively diffusion properties with high depth resolution, e.g. the hydrodynamic diameter of colloidal suspensions. Performance of DS-OCT is demonstrated with polystyrene particle suspensions and compared to conventional DLS measurements. Applications for DS-OCT may be found in the measurement of particle size distributions of inhomogeneous samples or measurements of diffusion properties at boundary surfaces. Additionally, the method has the capability to become a useful benefit in clinical diagnostics, especially in ophthalmology, where the molecular compositions and pathological changes of anterior eye components could be detected. © 2011 Copyright Society of Photo-Optical Instrumentation Engineers (SPIE).
AB - Diffusion-sensitive optical coherence tomography (DS-OCT) is presented as a functional extension to OCT. Fluctuations of signal intensity and phase, which are caused by Brownian motion, are analysed by an autocorrelation function similar to dynamic light scattering measurements. Based on an ultra-fast Fourier-domain OCT, DS-OCT can determine quantitatively diffusion properties with high depth resolution, e.g. the hydrodynamic diameter of colloidal suspensions. Performance of DS-OCT is demonstrated with polystyrene particle suspensions and compared to conventional DLS measurements. Applications for DS-OCT may be found in the measurement of particle size distributions of inhomogeneous samples or measurements of diffusion properties at boundary surfaces. Additionally, the method has the capability to become a useful benefit in clinical diagnostics, especially in ophthalmology, where the molecular compositions and pathological changes of anterior eye components could be detected. © 2011 Copyright Society of Photo-Optical Instrumentation Engineers (SPIE).
U2 - 10.1117/12.873815
DO - 10.1117/12.873815
M3 - Conference contribution
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV
T2 - Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV
Y2 - 24 January 2011 through 26 January 2011
ER -