Dimensional structure of one-year post-COVID-19 neuropsychiatric and somatic sequelae and association with role impairment

Owen N.W. Leung; Nicholas K.H. Chiu; Samuel Y.S. Wong; Pim Cuijpers; Jordi Alonso; Paul K.S. Chan; Grace Lui; Eliza Wong; Ronny Bruffaerts; Benjamin H.K. Yip; Philippe Mortier; Gemma Vilagut; Dora Kwok; Linda C.W. Lam; Ronald C. Kessler; Arthur D.P. Mak

doi:10.1038/s41598-023-39209-z

Dimensional structure of one-year post-COVID-19 neuropsychiatric and somatic sequelae and association with role impairment

Owen N.W. Leung, Nicholas K.H. Chiu, Samuel Y.S. Wong, Pim Cuijpers, Jordi Alonso, Paul K.S. Chan, Grace Lui, Eliza Wong, Ronny Bruffaerts, Benjamin H.K. Yip, Philippe Mortier, Gemma Vilagut, Dora Kwok, Linda C.W. Lam, Ronald C. Kessler, Arthur D.P. Mak^*

^*Corresponding author for this work

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

This study examined the latent structure of the broad range of complex neuropsychiatric morbidities occurring 1 year after COVID-19 infection. As part of the CU-COVID19 study, 248 (response rate=39.3%) of 631 adults hospitalized for COVID-19 infection in Hong Kong completed an online survey between March-2021 and January-2022. Disorder prevalence was compared against a random non-infected household sample (n=1834). 248 surveys were received on average 321 days post-infection (Mean age: 48.9, 54% female, moderate/severe/critical infection: 58.2%). 32.4% were screened to have at least one mental disorder, 78.7% of whom had concurrent fatigue/subjective cognitive impairment (SCI). Only PTSD (19.1%) was significantly more common than control (14%, p=0.047). Latent profile analysis classified individuals into P1 (12·4%)-no current neuropsychiatric morbidities, P2 (23.1%)-SCI/fatigue, P3 (45.2%)-anxiety/PTSD, P4 (19.3%)-depression. SCI and fatigue pervaded in all profiles (P2-4) with neuropsychiatric morbidities one-year post-infection. PTSD, anxiety and depressive symptoms were most important in differentiating P2-4. Past mental health and P4 independently predicted functional impairment. Neuropsychiatric morbidity was associated with past mental health, reduced resilience, financial problems, but not COVID-19 severity. Their confluence with depressive and anxiety symptoms predicted impairment and are associated with psychological and environmental factors.

Original language	English
Article number	12205
Pages (from-to)	1-11
Number of pages	11
Journal	Scientific Reports
Volume	13
DOIs	https://doi.org/10.1038/s41598-023-39209-z
Publication status	Published - 27 Jul 2023

Bibliographical note

Funding Information:
This work was supported by the Health and Medical Research Fund (MADP, grant number COVID190212), (CPKS, grant number COVID19F06); the Special Research Fund KULeuven (BR, grant number EDC-D9624-DOA/2020/007); Spain’s Instituto de Salud Carlos III (ISCIII-FSE) Miguel Servet post-doctoral grants (MP, grant number CP21/00078) and AGAUR, Generalitat de Catalunya (AJ, 2021 SGR 00624).

Publisher Copyright:
© 2023, The Author(s).

Funding

This work was supported by the Health and Medical Research Fund (MADP, grant number COVID190212), (CPKS, grant number COVID19F06); the Special Research Fund KULeuven (BR, grant number EDC-D9624-DOA/2020/007); Spain’s Instituto de Salud Carlos III (ISCIII-FSE) Miguel Servet post-doctoral grants (MP, grant number CP21/00078) and AGAUR, Generalitat de Catalunya (AJ, 2021 SGR 00624).

Funders	Funder number
ISCIII-FSE	CP21/00078
Special Research Fund KULeuven	EDC-D9624-DOA/2020/007
Generalitat de Catalunya	2021 SGR 00624
Generalitat de Catalunya
Agència de Gestió d'Ajuts Universitaris i de Recerca
Instituto de Salud Carlos III
Health and Medical Research Fund	COVID190212, COVID19F06
Health and Medical Research Fund

Access to Document

10.1038/s41598-023-39209-z

Persistent URL (handle)

Persistent link

Cite this

Leung, O. N. W., Chiu, N. K. H., Wong, S. Y. S., Cuijpers, P., Alonso, J., Chan, P. K. S., Lui, G., Wong, E., Bruffaerts, R., Yip, B. H. K., Mortier, P., Vilagut, G., Kwok, D., Lam, L. C. W., Kessler, R. C., & Mak, A. D. P. (2023). Dimensional structure of one-year post-COVID-19 neuropsychiatric and somatic sequelae and association with role impairment. Scientific Reports, 13, 1-11. Article 12205. https://doi.org/10.1038/s41598-023-39209-z

@article{a8b9bab0ca9b4d99bfb324bfb7d730d8,

title = "Dimensional structure of one-year post-COVID-19 neuropsychiatric and somatic sequelae and association with role impairment",

abstract = "This study examined the latent structure of the broad range of complex neuropsychiatric morbidities occurring 1 year after COVID-19 infection. As part of the CU-COVID19 study, 248 (response rate=39.3%) of 631 adults hospitalized for COVID-19 infection in Hong Kong completed an online survey between March-2021 and January-2022. Disorder prevalence was compared against a random non-infected household sample (n=1834). 248 surveys were received on average 321 days post-infection (Mean age: 48.9, 54% female, moderate/severe/critical infection: 58.2%). 32.4% were screened to have at least one mental disorder, 78.7% of whom had concurrent fatigue/subjective cognitive impairment (SCI). Only PTSD (19.1%) was significantly more common than control (14%, p=0.047). Latent profile analysis classified individuals into P1 (12·4%)-no current neuropsychiatric morbidities, P2 (23.1%)-SCI/fatigue, P3 (45.2%)-anxiety/PTSD, P4 (19.3%)-depression. SCI and fatigue pervaded in all profiles (P2-4) with neuropsychiatric morbidities one-year post-infection. PTSD, anxiety and depressive symptoms were most important in differentiating P2-4. Past mental health and P4 independently predicted functional impairment. Neuropsychiatric morbidity was associated with past mental health, reduced resilience, financial problems, but not COVID-19 severity. Their confluence with depressive and anxiety symptoms predicted impairment and are associated with psychological and environmental factors.",

author = "Leung, {Owen N.W.} and Chiu, {Nicholas K.H.} and Wong, {Samuel Y.S.} and Pim Cuijpers and Jordi Alonso and Chan, {Paul K.S.} and Grace Lui and Eliza Wong and Ronny Bruffaerts and Yip, {Benjamin H.K.} and Philippe Mortier and Gemma Vilagut and Dora Kwok and Lam, {Linda C.W.} and Kessler, {Ronald C.} and Mak, {Arthur D.P.}",

note = "Funding Information: This work was supported by the Health and Medical Research Fund (MADP, grant number COVID190212), (CPKS, grant number COVID19F06); the Special Research Fund KULeuven (BR, grant number EDC-D9624-DOA/2020/007); Spain{\textquoteright}s Instituto de Salud Carlos III (ISCIII-FSE) Miguel Servet post-doctoral grants (MP, grant number CP21/00078) and AGAUR, Generalitat de Catalunya (AJ, 2021 SGR 00624). Publisher Copyright: {\textcopyright} 2023, The Author(s).",

year = "2023",

month = jul,

day = "27",

doi = "10.1038/s41598-023-39209-z",

language = "English",

volume = "13",

pages = "1--11",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "Nature Research",

}

Leung, ONW, Chiu, NKH, Wong, SYS, Cuijpers, P, Alonso, J, Chan, PKS, Lui, G, Wong, E, Bruffaerts, R, Yip, BHK, Mortier, P, Vilagut, G, Kwok, D, Lam, LCW, Kessler, RC & Mak, ADP 2023, 'Dimensional structure of one-year post-COVID-19 neuropsychiatric and somatic sequelae and association with role impairment', Scientific Reports, vol. 13, 12205, pp. 1-11. https://doi.org/10.1038/s41598-023-39209-z

TY - JOUR

T1 - Dimensional structure of one-year post-COVID-19 neuropsychiatric and somatic sequelae and association with role impairment

AU - Leung, Owen N.W.

AU - Chiu, Nicholas K.H.

AU - Wong, Samuel Y.S.

AU - Cuijpers, Pim

AU - Alonso, Jordi

AU - Chan, Paul K.S.

AU - Lui, Grace

AU - Wong, Eliza

AU - Bruffaerts, Ronny

AU - Yip, Benjamin H.K.

AU - Mortier, Philippe

AU - Vilagut, Gemma

AU - Kwok, Dora

AU - Lam, Linda C.W.

AU - Kessler, Ronald C.

AU - Mak, Arthur D.P.

N1 - Funding Information: This work was supported by the Health and Medical Research Fund (MADP, grant number COVID190212), (CPKS, grant number COVID19F06); the Special Research Fund KULeuven (BR, grant number EDC-D9624-DOA/2020/007); Spain’s Instituto de Salud Carlos III (ISCIII-FSE) Miguel Servet post-doctoral grants (MP, grant number CP21/00078) and AGAUR, Generalitat de Catalunya (AJ, 2021 SGR 00624). Publisher Copyright: © 2023, The Author(s).

PY - 2023/7/27

Y1 - 2023/7/27

N2 - This study examined the latent structure of the broad range of complex neuropsychiatric morbidities occurring 1 year after COVID-19 infection. As part of the CU-COVID19 study, 248 (response rate=39.3%) of 631 adults hospitalized for COVID-19 infection in Hong Kong completed an online survey between March-2021 and January-2022. Disorder prevalence was compared against a random non-infected household sample (n=1834). 248 surveys were received on average 321 days post-infection (Mean age: 48.9, 54% female, moderate/severe/critical infection: 58.2%). 32.4% were screened to have at least one mental disorder, 78.7% of whom had concurrent fatigue/subjective cognitive impairment (SCI). Only PTSD (19.1%) was significantly more common than control (14%, p=0.047). Latent profile analysis classified individuals into P1 (12·4%)-no current neuropsychiatric morbidities, P2 (23.1%)-SCI/fatigue, P3 (45.2%)-anxiety/PTSD, P4 (19.3%)-depression. SCI and fatigue pervaded in all profiles (P2-4) with neuropsychiatric morbidities one-year post-infection. PTSD, anxiety and depressive symptoms were most important in differentiating P2-4. Past mental health and P4 independently predicted functional impairment. Neuropsychiatric morbidity was associated with past mental health, reduced resilience, financial problems, but not COVID-19 severity. Their confluence with depressive and anxiety symptoms predicted impairment and are associated with psychological and environmental factors.

AB - This study examined the latent structure of the broad range of complex neuropsychiatric morbidities occurring 1 year after COVID-19 infection. As part of the CU-COVID19 study, 248 (response rate=39.3%) of 631 adults hospitalized for COVID-19 infection in Hong Kong completed an online survey between March-2021 and January-2022. Disorder prevalence was compared against a random non-infected household sample (n=1834). 248 surveys were received on average 321 days post-infection (Mean age: 48.9, 54% female, moderate/severe/critical infection: 58.2%). 32.4% were screened to have at least one mental disorder, 78.7% of whom had concurrent fatigue/subjective cognitive impairment (SCI). Only PTSD (19.1%) was significantly more common than control (14%, p=0.047). Latent profile analysis classified individuals into P1 (12·4%)-no current neuropsychiatric morbidities, P2 (23.1%)-SCI/fatigue, P3 (45.2%)-anxiety/PTSD, P4 (19.3%)-depression. SCI and fatigue pervaded in all profiles (P2-4) with neuropsychiatric morbidities one-year post-infection. PTSD, anxiety and depressive symptoms were most important in differentiating P2-4. Past mental health and P4 independently predicted functional impairment. Neuropsychiatric morbidity was associated with past mental health, reduced resilience, financial problems, but not COVID-19 severity. Their confluence with depressive and anxiety symptoms predicted impairment and are associated with psychological and environmental factors.

UR - http://www.scopus.com/inward/record.url?scp=85165936126&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85165936126&partnerID=8YFLogxK

U2 - 10.1038/s41598-023-39209-z

DO - 10.1038/s41598-023-39209-z

M3 - Article

C2 - 37500708

AN - SCOPUS:85165936126

SN - 2045-2322

VL - 13

SP - 1

EP - 11

JO - Scientific Reports

JF - Scientific Reports

M1 - 12205

ER -

Dimensional structure of one-year post-COVID-19 neuropsychiatric and somatic sequelae and association with role impairment

Abstract

Bibliographical note

Funding

Access to Document

Persistent URL (handle)

Other files and links

Fingerprint

Cite this