Direct Blood Flow Measurements in a Free RPE-Choroid Graft with Phase-Resolved Doppler OCT

Elsbeth J. T. van Zeeburg; Boy Braaf; Matteo G. Cereda; Jan C. van Meurs; Johannes F. de Boer

doi:10.1167/tvst.4.1.2

Direct Blood Flow Measurements in a Free RPE-Choroid Graft with Phase-Resolved Doppler OCT

Elsbeth J. T. van Zeeburg
, Boy Braaf
, Matteo G. Cereda
, Jan C. van Meurs
, Johannes F. de Boer

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Purpose: : We directly demonstrated the revascularization in a free retinal pigment epithelium (RPE)-choroid graft with direct blood flow detection by experimental phase-resolved Doppler optical coherence tomography (PRD-OCT).

Methods: : Seven patients with age-related macular degeneration underwent an RPE-choroid graft translocation in a prospective institutional cohort study. Spectral domain optical coherence tomography (SD-OCT) was used to measure the revascularization stage. With PRD-OCT the presence of flow was imaged postoperatively.

Results: : The PRD-OCT confirmed flow in three patients when SD-OCT indicated the afferent vessel ingrowth stage, and in all seven patients when the SD-OCT indicated the efferent vessel ingrowth stage.

Conclusions: : The PRD-OCT study was able to detect the presence of blood flow in a free RPE-choroid graft. The PRD-OCT findings directly confirmed the revascularization that was otherwise based on the more circumstantial evidence provided by SD-OCT images and angiography.

Translational Relevance: : The use of both techniques to monitor the revascularization process in a free graft in patients are an interesting example of replacing more invasive by noninvasive techniques. There is potential future use of PRD-OCT for the visualization of vascularization patterns in other pathologies.

Original language	English
Journal	Translational Vision Science & Technology (TVST)
Volume	4
Issue number	1
DOIs	https://doi.org/10.1167/tvst.4.1.2
Publication status	Published - Jan 2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

RPE-choroid graft
phase-resolved doppler OCT
SD-OCT

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10.1167/tvst.4.1.2

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@article{7a5e0c463cdf44beb4da269c2f9ece4d,

title = "Direct Blood Flow Measurements in a Free RPE-Choroid Graft with Phase-Resolved Doppler OCT",

abstract = "Purpose: : We directly demonstrated the revascularization in a free retinal pigment epithelium (RPE)-choroid graft with direct blood flow detection by experimental phase-resolved Doppler optical coherence tomography (PRD-OCT). Methods: : Seven patients with age-related macular degeneration underwent an RPE-choroid graft translocation in a prospective institutional cohort study. Spectral domain optical coherence tomography (SD-OCT) was used to measure the revascularization stage. With PRD-OCT the presence of flow was imaged postoperatively. Results: : The PRD-OCT confirmed flow in three patients when SD-OCT indicated the afferent vessel ingrowth stage, and in all seven patients when the SD-OCT indicated the efferent vessel ingrowth stage. Conclusions: : The PRD-OCT study was able to detect the presence of blood flow in a free RPE-choroid graft. The PRD-OCT findings directly confirmed the revascularization that was otherwise based on the more circumstantial evidence provided by SD-OCT images and angiography. Translational Relevance: : The use of both techniques to monitor the revascularization process in a free graft in patients are an interesting example of replacing more invasive by noninvasive techniques. There is potential future use of PRD-OCT for the visualization of vascularization patterns in other pathologies. ",

keywords = "RPE-choroid graft, phase-resolved doppler OCT, SD-OCT",

author = "\{van Zeeburg\}, \{Elsbeth J. T.\} and Boy Braaf and Cereda, \{Matteo G.\} and \{van Meurs\}, \{Jan C.\} and \{de Boer\}, \{Johannes F.\}",

year = "2015",

month = jan,

doi = "10.1167/tvst.4.1.2",

language = "English",

volume = "4",

journal = "Translational Vision Science \& Technology (TVST)",

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publisher = "Association for Research in Vision and Ophthalmology Inc.",

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}

TY - JOUR

T1 - Direct Blood Flow Measurements in a Free RPE-Choroid Graft with Phase-Resolved Doppler OCT

AU - van Zeeburg, Elsbeth J. T.

AU - Braaf, Boy

AU - Cereda, Matteo G.

AU - van Meurs, Jan C.

AU - de Boer, Johannes F.

PY - 2015/1

Y1 - 2015/1

N2 - Purpose: : We directly demonstrated the revascularization in a free retinal pigment epithelium (RPE)-choroid graft with direct blood flow detection by experimental phase-resolved Doppler optical coherence tomography (PRD-OCT). Methods: : Seven patients with age-related macular degeneration underwent an RPE-choroid graft translocation in a prospective institutional cohort study. Spectral domain optical coherence tomography (SD-OCT) was used to measure the revascularization stage. With PRD-OCT the presence of flow was imaged postoperatively. Results: : The PRD-OCT confirmed flow in three patients when SD-OCT indicated the afferent vessel ingrowth stage, and in all seven patients when the SD-OCT indicated the efferent vessel ingrowth stage. Conclusions: : The PRD-OCT study was able to detect the presence of blood flow in a free RPE-choroid graft. The PRD-OCT findings directly confirmed the revascularization that was otherwise based on the more circumstantial evidence provided by SD-OCT images and angiography. Translational Relevance: : The use of both techniques to monitor the revascularization process in a free graft in patients are an interesting example of replacing more invasive by noninvasive techniques. There is potential future use of PRD-OCT for the visualization of vascularization patterns in other pathologies.

AB - Purpose: : We directly demonstrated the revascularization in a free retinal pigment epithelium (RPE)-choroid graft with direct blood flow detection by experimental phase-resolved Doppler optical coherence tomography (PRD-OCT). Methods: : Seven patients with age-related macular degeneration underwent an RPE-choroid graft translocation in a prospective institutional cohort study. Spectral domain optical coherence tomography (SD-OCT) was used to measure the revascularization stage. With PRD-OCT the presence of flow was imaged postoperatively. Results: : The PRD-OCT confirmed flow in three patients when SD-OCT indicated the afferent vessel ingrowth stage, and in all seven patients when the SD-OCT indicated the efferent vessel ingrowth stage. Conclusions: : The PRD-OCT study was able to detect the presence of blood flow in a free RPE-choroid graft. The PRD-OCT findings directly confirmed the revascularization that was otherwise based on the more circumstantial evidence provided by SD-OCT images and angiography. Translational Relevance: : The use of both techniques to monitor the revascularization process in a free graft in patients are an interesting example of replacing more invasive by noninvasive techniques. There is potential future use of PRD-OCT for the visualization of vascularization patterns in other pathologies.

KW - RPE-choroid graft

KW - phase-resolved doppler OCT

KW - SD-OCT

U2 - 10.1167/tvst.4.1.2

DO - 10.1167/tvst.4.1.2

M3 - Article

SN - 2164-2591

VL - 4

JO - Translational Vision Science & Technology (TVST)

JF - Translational Vision Science & Technology (TVST)

IS - 1

ER -

Direct Blood Flow Measurements in a Free RPE-Choroid Graft with Phase-Resolved Doppler OCT

Abstract

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