Direct decarboxylative18F-fluorination of benzoic acids using visible light catalysis

Lizeth Y.F. Haveman; Cornelis A.J. Broersen; Danielle J. Vugts; Albert D. Windhorst

doi:10.1039/d5cc03503a

Direct decarboxylative¹⁸F-fluorination of benzoic acids using visible light catalysis

Lizeth Y.F. Haveman^*, Cornelis A.J. Broersen, Danielle J. Vugts, Albert D. Windhorst

^*Corresponding author for this work

Chemistry and Pharmaceutical Sciences

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

This study introduces a mild method for the direct decarboxylative¹⁸F-fluorination of (hetero)aromatic carboxylic acids via a photoinduced ligand-to-metal charge transfer (LMCT) process. The method allows for the succesfull¹⁸F-labeling of various benzoic acids (16–40% RCC) and the full-batch preparation of 1-fluoro-4-[¹⁸F]fluorobenzene with an overall RCY of 27 ± 2%.

Original language	English
Pages (from-to)	19505-19508
Number of pages	4
Journal	Chemical Communications
Volume	61
Issue number	98
Early online date	18 Nov 2025
DOIs	https://doi.org/10.1039/d5cc03503a
Publication status	Published - 21 Dec 2025

Bibliographical note

Publisher Copyright:
This journal is © The Royal Society of Chemistry, 2025

Access to Document

10.1039/d5cc03503aLicence: CC BY

Persistent URL (handle)

Persistent link

Cite this

@article{0bba19185ff9434b9decbb3f2f25aeae,

title = "Direct decarboxylative18F-fluorination of benzoic acids using visible light catalysis",

abstract = "This study introduces a mild method for the direct decarboxylative18F-fluorination of (hetero)aromatic carboxylic acids via a photoinduced ligand-to-metal charge transfer (LMCT) process. The method allows for the succesfull18F-labeling of various benzoic acids (16–40\% RCC) and the full-batch preparation of 1-fluoro-4-[18F]fluorobenzene with an overall RCY of 27 ± 2\%.",

author = "Haveman, \{Lizeth Y.F.\} and Broersen, \{Cornelis A.J.\} and Vugts, \{Danielle J.\} and Windhorst, \{Albert D.\}",

note = "Publisher Copyright: This journal is {\textcopyright} The Royal Society of Chemistry, 2025",

year = "2025",

month = dec,

day = "21",

doi = "10.1039/d5cc03503a",

language = "English",

volume = "61",

pages = "19505--19508",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "98",

}

TY - JOUR

T1 - Direct decarboxylative18F-fluorination of benzoic acids using visible light catalysis

AU - Haveman, Lizeth Y.F.

AU - Broersen, Cornelis A.J.

AU - Vugts, Danielle J.

AU - Windhorst, Albert D.

N1 - Publisher Copyright: This journal is © The Royal Society of Chemistry, 2025

PY - 2025/12/21

Y1 - 2025/12/21

N2 - This study introduces a mild method for the direct decarboxylative18F-fluorination of (hetero)aromatic carboxylic acids via a photoinduced ligand-to-metal charge transfer (LMCT) process. The method allows for the succesfull18F-labeling of various benzoic acids (16–40% RCC) and the full-batch preparation of 1-fluoro-4-[18F]fluorobenzene with an overall RCY of 27 ± 2%.

AB - This study introduces a mild method for the direct decarboxylative18F-fluorination of (hetero)aromatic carboxylic acids via a photoinduced ligand-to-metal charge transfer (LMCT) process. The method allows for the succesfull18F-labeling of various benzoic acids (16–40% RCC) and the full-batch preparation of 1-fluoro-4-[18F]fluorobenzene with an overall RCY of 27 ± 2%.

UR - https://www.scopus.com/pages/publications/105024021770

UR - https://www.scopus.com/inward/citedby.url?scp=105024021770&partnerID=8YFLogxK

U2 - 10.1039/d5cc03503a

DO - 10.1039/d5cc03503a

M3 - Article

C2 - 41251250

AN - SCOPUS:105024021770

SN - 1359-7345

VL - 61

SP - 19505

EP - 19508

JO - Chemical Communications

JF - Chemical Communications

IS - 98

ER -