Discovery of key whole-brain transitions and dynamics during human wakefulness and non-REM sleep

A. B.A. Stevner, D. Vidaurre, J. Cabral, K. Rapuano, S. F.V. Nielsen, E. Tagliazucchi, H. Laufs, P. Vuust, G. Deco, M. W. Woolrich, E. Van Someren, M. L. Kringelbach

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

The modern understanding of sleep is based on the classification of sleep into stages defined by their electroencephalography (EEG) signatures, but the underlying brain dynamics remain unclear. Here we aimed to move significantly beyond the current state-of-the-art description of sleep, and in particular to characterise the spatiotemporal complexity of whole-brain networks and state transitions during sleep. In order to obtain the most unbiased estimate of how whole-brain network states evolve through the human sleep cycle, we used a Markovian data-driven analysis of continuous neuroimaging data from 57 healthy participants falling asleep during simultaneous functional magnetic resonance imaging (fMRI) and EEG. This Hidden Markov Model (HMM) facilitated discovery of the dynamic choreography between different whole-brain networks across the wake-non-REM sleep cycle. Notably, our results reveal key trajectories to switch within and between EEG-based sleep stages, while highlighting the heterogeneities of stage N1 sleep and wakefulness before and after sleep.

LanguageEnglish
Article number1035
Pages1-14
Number of pages14
JournalNature Communications
Volume10
Issue number1
DOIs
Publication statusPublished - 4 Mar 2019

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wakefulness
sleep
Wakefulness
brain
Brain
Sleep
Sleep Stages
Electroencephalography
electroencephalography
Neuroimaging
Healthy Volunteers
cycles
Magnetic Resonance Imaging
Hidden Markov models
falling
wakes
magnetic resonance

Cite this

Stevner, A. B. A., Vidaurre, D., Cabral, J., Rapuano, K., Nielsen, S. F. V., Tagliazucchi, E., ... Kringelbach, M. L. (2019). Discovery of key whole-brain transitions and dynamics during human wakefulness and non-REM sleep. Nature Communications, 10(1), 1-14. [1035]. https://doi.org/10.1038/s41467-019-08934-3
Stevner, A. B.A. ; Vidaurre, D. ; Cabral, J. ; Rapuano, K. ; Nielsen, S. F.V. ; Tagliazucchi, E. ; Laufs, H. ; Vuust, P. ; Deco, G. ; Woolrich, M. W. ; Van Someren, E. ; Kringelbach, M. L. / Discovery of key whole-brain transitions and dynamics during human wakefulness and non-REM sleep. In: Nature Communications. 2019 ; Vol. 10, No. 1. pp. 1-14.
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Stevner, ABA, Vidaurre, D, Cabral, J, Rapuano, K, Nielsen, SFV, Tagliazucchi, E, Laufs, H, Vuust, P, Deco, G, Woolrich, MW, Van Someren, E & Kringelbach, ML 2019, 'Discovery of key whole-brain transitions and dynamics during human wakefulness and non-REM sleep', Nature Communications, vol. 10, no. 1, 1035, pp. 1-14. https://doi.org/10.1038/s41467-019-08934-3

Discovery of key whole-brain transitions and dynamics during human wakefulness and non-REM sleep. / Stevner, A. B.A.; Vidaurre, D.; Cabral, J.; Rapuano, K.; Nielsen, S. F.V.; Tagliazucchi, E.; Laufs, H.; Vuust, P.; Deco, G.; Woolrich, M. W.; Van Someren, E.; Kringelbach, M. L.

In: Nature Communications, Vol. 10, No. 1, 1035, 04.03.2019, p. 1-14.

Research output: Contribution to JournalArticleAcademicpeer-review

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Stevner ABA, Vidaurre D, Cabral J, Rapuano K, Nielsen SFV, Tagliazucchi E et al. Discovery of key whole-brain transitions and dynamics during human wakefulness and non-REM sleep. Nature Communications. 2019 Mar 4;10(1):1-14. 1035. https://doi.org/10.1038/s41467-019-08934-3