Discrepancies of polygenic effects on symptom dimensions between adolescents and adults with ADHD

W. Jiang, K. Rootes-Murdy, K. Duan, G. Schoenmacker, P.J. Hoekstra, C.A. Hartman, J. Oosterlaan, D. Heslenfeld, B. Franke, E. Sprooten, J. Buitelaar, A. Arias-Vasquez, J. Liu, J.A. Turner

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Abstract

A significant proportion of individuals with attention-deficit/hyperactivity disorder (ADHD) show persistence into adulthood. The genetic and neural correlates of ADHD in adolescents versus adults remain poorly characterized. We investigated ADHD polygenic risk score (PRS) in relation to previously identified gray matter (GM) patterns, neurocognitive, and symptom findings in the same ADHD sample (462 adolescents & 422 adults from the NeuroIMAGE and IMpACT cohorts). Significant effects of ADHD PRS were found on hyperactivity and impulsivity symptoms in adolescents, hyperactivity symptom in adults, but not GM volume components. A distinct PRS effect between adolescents and adults on individual ADHD symptoms is suggested.
Original languageEnglish
Article number111282
Pages (from-to)1-4
Number of pages4
JournalPsychiatry Research - Neuroimaging
Volume311
Early online date20 Mar 2021
DOIs
Publication statusPublished - 30 May 2021

Funding

This study was supported by the National Institutes of Health and The National Institute of Mental Health through the grant 1R01MH106655 . This NeuroIMAGE study was supported by NIH Grant R01MH62873 , NWO Large Investment Grant 1750102007010 and grants from Radboud University Medical Center, University Medical Center Groningen and Accare, and VU University Amsterdam. This work was also supported by grants from NWO Brain & Cognition ( 433–09–242 and 056–13–015 ) and from ZonMW (60–60600–97–193). Further support was received from the European Union's FP7 program under grant agreement no. 278948 (TACTICS), no. 602450 (IMAGEMEND), no. 602805 (Aggressotype), and from the European Union's Horizon 2020 research and innovation program under grant agreement no. 667302 (CoCA) and no. 728018 (Eat2beNICE). Barbara Franke receives funding from a personal Vici grant (to Barbara Franke) of the Netherlands Organization for Scientific Research (NWO, grant numbers 433–09–229 and 016–130–669 ) and a pilot grant of the Dutch National Research Agenda for the NeuroLabNL project.

FundersFunder number
Dutch National Research Agenda
European Union's FP7602805, 602450, 278948
National Institutes of Health
National Institute of Mental HealthR01MH062873, 1R01MH106655
Chiropractic and Osteopathic College of Australasia728018
ZonMw60–60600–97–193
Vrije Universiteit Amsterdam056–13–015, 433–09–242
Nederlandse Organisatie voor Wetenschappelijk Onderzoek016–130–669, 1750102007010, 433–09–229
Horizon 2020667302

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