Discrepancies of polygenic effects on symptom dimensions between adolescents and adults with ADHD

W. Jiang; K. Rootes-Murdy; K. Duan; G. Schoenmacker; P.J. Hoekstra; C.A. Hartman; J. Oosterlaan; D. Heslenfeld; B. Franke; E. Sprooten; J. Buitelaar; A. Arias-Vasquez; J. Liu; J.A. Turner

doi:10.1016/j.pscychresns.2021.111282

Discrepancies of polygenic effects on symptom dimensions between adolescents and adults with ADHD

W. Jiang, K. Rootes-Murdy, K. Duan, G. Schoenmacker, P.J. Hoekstra, C.A. Hartman, J. Oosterlaan, D. Heslenfeld, B. Franke, E. Sprooten, J. Buitelaar, A. Arias-Vasquez, J. Liu, J.A. Turner

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Abstract

A significant proportion of individuals with attention-deficit/hyperactivity disorder (ADHD) show persistence into adulthood. The genetic and neural correlates of ADHD in adolescents versus adults remain poorly characterized. We investigated ADHD polygenic risk score (PRS) in relation to previously identified gray matter (GM) patterns, neurocognitive, and symptom findings in the same ADHD sample (462 adolescents & 422 adults from the NeuroIMAGE and IMpACT cohorts). Significant effects of ADHD PRS were found on hyperactivity and impulsivity symptoms in adolescents, hyperactivity symptom in adults, but not GM volume components. A distinct PRS effect between adolescents and adults on individual ADHD symptoms is suggested.

Original language	English
Article number	111282
Pages (from-to)	1-4
Number of pages	4
Journal	Psychiatry Research - Neuroimaging
Volume	311
Early online date	20 Mar 2021
DOIs	https://doi.org/10.1016/j.pscychresns.2021.111282
Publication status	Published - 30 May 2021

Funding

This study was supported by the National Institutes of Health and The National Institute of Mental Health through the grant 1R01MH106655. This NeuroIMAGE study was supported by NIH Grant R01MH62873, NWO Large Investment Grant 1750102007010 and grants from Radboud University Medical Center, University Medical Center Groningen and Accare, and VU University Amsterdam. This work was also supported by grants from NWO Brain & Cognition (433?09?242 and 056?13?015) and from ZonMW (60?60600?97?193). Further support was received from the European Union's FP7 program under grant agreement no. 278948 (TACTICS), no. 602450 (IMAGEMEND), no. 602805 (Aggressotype), and from the European Union's Horizon 2020 research and innovation program under grant agreement no. 667302 (CoCA) and no. 728018 (Eat2beNICE). Barbara Franke receives funding from a personal Vici grant (to Barbara Franke) of the Netherlands Organization for Scientific Research (NWO, grant numbers 433?09?229 and 016?130?669) and a pilot grant of the Dutch National Research Agenda for the NeuroLabNL project. This study was supported by the National Institutes of Health and The National Institute of Mental Health through the grant 1R01MH106655 . This NeuroIMAGE study was supported by NIH Grant R01MH62873 , NWO Large Investment Grant 1750102007010 and grants from Radboud University Medical Center, University Medical Center Groningen and Accare, and VU University Amsterdam. This work was also supported by grants from NWO Brain & Cognition ( 433–09–242 and 056–13–015 ) and from ZonMW (60–60600–97–193). Further support was received from the European Union's FP7 program under grant agreement no. 278948 (TACTICS), no. 602450 (IMAGEMEND), no. 602805 (Aggressotype), and from the European Union's Horizon 2020 research and innovation program under grant agreement no. 667302 (CoCA) and no. 728018 (Eat2beNICE). Barbara Franke receives funding from a personal Vici grant (to Barbara Franke) of the Netherlands Organization for Scientific Research (NWO, grant numbers 433–09–229 and 016–130–669 ) and a pilot grant of the Dutch National Research Agenda for the NeuroLabNL project.

Funders	Funder number
European Union's FP7
Dutch National Research Agenda
National Institutes of Health
European Commission
Chiropractic and Osteopathic College of Australasia
Horizon 2020
Horizon 2020 Framework Programme	728018
ZonMw	60600, 60–60600–97–193
Vrije Universiteit Amsterdam	056–13–015, 433–09–242
Seventh Framework Programme	602805, 602450, 667302, 278948
Nederlandse Organisatie voor Wetenschappelijk Onderzoek	433–09–229, 1750102007010, 016.130.669, 669
National Institute of Mental Health	R01MH062873, R01MH106655

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10.1016/j.pscychresns.2021.111282

Discrepancies of polygenic effects on symptom dimensions between adolescents and adults with ADHDFinal published version, 497 KBLicence: Article 25fa Dutch Copyright Act

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Jiang, W., Rootes-Murdy, K., Duan, K., Schoenmacker, G., Hoekstra, P. J., Hartman, C. A., Oosterlaan, J., Heslenfeld, D., Franke, B., Sprooten, E., Buitelaar, J., Arias-Vasquez, A., Liu, J., & Turner, J. A. (2021). Discrepancies of polygenic effects on symptom dimensions between adolescents and adults with ADHD. Psychiatry Research - Neuroimaging, 311, 1-4. Article 111282. https://doi.org/10.1016/j.pscychresns.2021.111282

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Jiang, W, Rootes-Murdy, K, Duan, K, Schoenmacker, G, Hoekstra, PJ, Hartman, CA, Oosterlaan, J, Heslenfeld, D, Franke, B, Sprooten, E, Buitelaar, J, Arias-Vasquez, A, Liu, J & Turner, JA 2021, 'Discrepancies of polygenic effects on symptom dimensions between adolescents and adults with ADHD', Psychiatry Research - Neuroimaging, vol. 311, 111282, pp. 1-4. https://doi.org/10.1016/j.pscychresns.2021.111282

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Discrepancies of polygenic effects on symptom dimensions between adolescents and adults with ADHD

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