Abstract
In searching for clinical biomarkers of the somatosensory function, we studied reproducibility of somatosensory potentials (SEP) evoked by finger stimulation in healthy subjects. SEPs induced by electrical stimulation and especially after median nerve stimulation is a method widely used in the literature. It is unclear, however, if the EEG recordings after finger stimulation are reproducible within the same subject. We tested in five healthy subjects the consistency and reproducibility of responses through bootstrapping as well as test–retest recordings. We further evaluated the possibility to discriminate activity of different fingers both at electrode and at source level. The lack of consistency and reproducibility suggest responses to finger stimulation to be unreliable, even with reasonably high signal-to-noise ratio and adequate number of trials. At sources level, somatotopic arrangement of the fingers representation was only found in one of the subjects. Although finding distinct locations of the different fingers activation was possible, our protocol did not allow for non-overlapping dipole representations of the fingers. We conclude that despite its theoretical advantages, we cannot recommend the use of somatosensory potentials evoked by finger stimulation to extract clinical biomarkers.
| Original language | English |
|---|---|
| Pages (from-to) | 498-512 |
| Number of pages | 15 |
| Journal | Brain Topography |
| Volume | 31 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - May 2018 |
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Keywords
- Clinical biomarkers
- EEG
- Representation of fingers
- Reproducibility
- Somatosensory evoked potentials
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Disentangling Somatosensory Evoked Potentials of the Fingers : Limitations and Clinical Potential. / Kalogianni, Konstantina; Daffertshofer, Andreas; van der Helm, Frans C.T.; Schouten, Alfred C.; de Munck, Jan C.; Kwakkel, Gert; Meskers, Carel G.M.; van Wegen, Erwin E.H.; Andringa, Aukje S.; Hoevenaars, Dirk; Winters, Caroline; Zandvliet, Sarah; Solis-Escalante, Teodoro; Yuan-Yang; Vlaar, Martijn P.; Filatova, Lena; Dewald, Julius P.A.; Yao, Jun; On Behalf Of The 4Deeg Consortium.
In: Brain Topography, Vol. 31, No. 3, 05.2018, p. 498-512.Research output: Contribution to Journal › Article › Academic › peer-review
TY - JOUR
T1 - Disentangling Somatosensory Evoked Potentials of the Fingers
T2 - Limitations and Clinical Potential
AU - Kalogianni, Konstantina
AU - Daffertshofer, Andreas
AU - van der Helm, Frans C.T.
AU - Schouten, Alfred C.
AU - de Munck, Jan C.
AU - Kwakkel, Gert
AU - Meskers, Carel G.M.
AU - van Wegen, Erwin E.H.
AU - Andringa, Aukje S.
AU - Hoevenaars, Dirk
AU - Winters, Caroline
AU - Zandvliet, Sarah
AU - Solis-Escalante, Teodoro
AU - Yuan-Yang,
AU - Vlaar, Martijn P.
AU - Filatova, Lena
AU - Dewald, Julius P.A.
AU - Yao, Jun
AU - On Behalf Of The 4Deeg Consortium
PY - 2018/5
Y1 - 2018/5
N2 - In searching for clinical biomarkers of the somatosensory function, we studied reproducibility of somatosensory potentials (SEP) evoked by finger stimulation in healthy subjects. SEPs induced by electrical stimulation and especially after median nerve stimulation is a method widely used in the literature. It is unclear, however, if the EEG recordings after finger stimulation are reproducible within the same subject. We tested in five healthy subjects the consistency and reproducibility of responses through bootstrapping as well as test–retest recordings. We further evaluated the possibility to discriminate activity of different fingers both at electrode and at source level. The lack of consistency and reproducibility suggest responses to finger stimulation to be unreliable, even with reasonably high signal-to-noise ratio and adequate number of trials. At sources level, somatotopic arrangement of the fingers representation was only found in one of the subjects. Although finding distinct locations of the different fingers activation was possible, our protocol did not allow for non-overlapping dipole representations of the fingers. We conclude that despite its theoretical advantages, we cannot recommend the use of somatosensory potentials evoked by finger stimulation to extract clinical biomarkers.
AB - In searching for clinical biomarkers of the somatosensory function, we studied reproducibility of somatosensory potentials (SEP) evoked by finger stimulation in healthy subjects. SEPs induced by electrical stimulation and especially after median nerve stimulation is a method widely used in the literature. It is unclear, however, if the EEG recordings after finger stimulation are reproducible within the same subject. We tested in five healthy subjects the consistency and reproducibility of responses through bootstrapping as well as test–retest recordings. We further evaluated the possibility to discriminate activity of different fingers both at electrode and at source level. The lack of consistency and reproducibility suggest responses to finger stimulation to be unreliable, even with reasonably high signal-to-noise ratio and adequate number of trials. At sources level, somatotopic arrangement of the fingers representation was only found in one of the subjects. Although finding distinct locations of the different fingers activation was possible, our protocol did not allow for non-overlapping dipole representations of the fingers. We conclude that despite its theoretical advantages, we cannot recommend the use of somatosensory potentials evoked by finger stimulation to extract clinical biomarkers.
KW - Clinical biomarkers
KW - EEG
KW - Representation of fingers
KW - Reproducibility
KW - Somatosensory evoked potentials
UR - http://www.scopus.com/inward/record.url?scp=85040693512&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85040693512&partnerID=8YFLogxK
U2 - 10.1007/s10548-017-0617-4
DO - 10.1007/s10548-017-0617-4
M3 - Article
VL - 31
SP - 498
EP - 512
JO - Brain Topography
JF - Brain Topography
SN - 0896-0267
IS - 3
ER -