Disorders of continence and defaecation: Insights into risk factors, underlying pathophysiology and treatment

Paul Franciscus Vollebregt

    Research output: PhD ThesisPhD-Thesis - Research and graduation internal

    321 Downloads (Pure)

    Abstract

    Faecal incontinence (uncontrolled loss of stool) and constipation are common symptoms which can have a negative impact on quality of life. In this thesis we evaluated potential underlying pathophysiological mechanisms, some of which require further investigation to evaluate clinical importance (anal motor dysfunction), while others were shown to impact on symptom profile and severity (rectal sensorimotor dysfunction). Conservative (transanal irrigation) and surgical (sacral neuromodulation) treatment were studied, aiming to improve future management in these patients.
    Original languageEnglish
    QualificationPhD
    Awarding Institution
    • Vrije Universiteit Amsterdam
    Supervisors/Advisors
    • Felt-Bersma, R.J.F., Supervisor, -
    • Knowles, C.H., Supervisor, -
    • Bouma, G., Co-supervisor, -
    • Scott, S.M., Co-supervisor, -
    Award date24 Jun 2022
    Place of PublicationAmsterdam
    Publisher
    Print ISBNs9789464217445
    Electronic ISBNs9789464217445
    Publication statusPublished - 24 Jun 2022

    Keywords

    • Anorectal physiology, anorectal manometry, constipation, faecal incontinence, neuromodulation, pellvic floor

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