Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation.

D. Bottai, M. di Luca, L. Majlessi, W. Frigui, R. Simeone, F. Sayes, W. Bitter, M.J. Brennan, C. Leclerc, G. Batoni, M. Campa, R. Brosch, S. Esin

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

The chromosome of Mycobacterium tuberculosis encodes five type VII secretion systems (ESX-1-ESX-5). While the role of the ESX-1 and ESX-3 systems in M. tuberculosis has been elucidated, predictions for the function of the ESX-5 system came from data obtained in Mycobacterium marinum, where it transports PPE and PE-PGRS proteins and modulates innate immune responses. To define the role of the ESX-5 system in M. tuberculosis, in this study, we have constructed five M. tuberculosis H37Rv ESX-5 knockout/deletion mutants, inactivating eccA
Original languageEnglish
Pages (from-to)1195-1209
Number of pages15
JournalMolecular Microbiology
Volume83
Issue number6
Early online date20 Feb 2012
DOIs
Publication statusPublished - Mar 2012

Fingerprint

Dive into the research topics of 'Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation.'. Together they form a unique fingerprint.

Cite this