Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation.

D. Bottai; M. di Luca; L. Majlessi; W. Frigui; R. Simeone; F. Sayes; W. Bitter; M.J. Brennan; C. Leclerc; G. Batoni; M. Campa; R. Brosch; S. Esin

doi:10.1111/j.1365-2958.2012.08001.x

Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation.

D. Bottai
, M. di Luca
, L. Majlessi
, W. Frigui
, R. Simeone
, F. Sayes
, W. Bitter
, M.J. Brennan
, C. Leclerc
, G. Batoni
, M. Campa
, R. Brosch
, S. Esin

AIMMS

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

The chromosome of Mycobacterium tuberculosis encodes five type VII secretion systems (ESX-1-ESX-5). While the role of the ESX-1 and ESX-3 systems in M. tuberculosis has been elucidated, predictions for the function of the ESX-5 system came from data obtained in Mycobacterium marinum, where it transports PPE and PE-PGRS proteins and modulates innate immune responses. To define the role of the ESX-5 system in M. tuberculosis, in this study, we have constructed five M. tuberculosis H37Rv ESX-5 knockout/deletion mutants, inactivating eccA

Original language	English
Pages (from-to)	1195-1209
Number of pages	15
Journal	Molecular Microbiology
Volume	83
Issue number	6
Early online date	20 Feb 2012
DOIs	https://doi.org/10.1111/j.1365-2958.2012.08001.x
Publication status	Published - Mar 2012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 14 Life Below Water

Access to Document

10.1111/j.1365-2958.2012.08001.x

Persistent URL (handle)

Persistent link

Cite this

Bottai, D., di Luca, M., Majlessi, L., Frigui, W., Simeone, R., Sayes, F., Bitter, W., Brennan, M. J., Leclerc, C., Batoni, G., Campa, M., Brosch, R., & Esin, S. (2012). Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation. Molecular Microbiology, 83(6), 1195-1209. https://doi.org/10.1111/j.1365-2958.2012.08001.x

@article{40d69228828649b3beed18694ef1f681,

title = "Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation.",

abstract = "The chromosome of Mycobacterium tuberculosis encodes five type VII secretion systems (ESX-1-ESX-5). While the role of the ESX-1 and ESX-3 systems in M. tuberculosis has been elucidated, predictions for the function of the ESX-5 system came from data obtained in Mycobacterium marinum, where it transports PPE and PE-PGRS proteins and modulates innate immune responses. To define the role of the ESX-5 system in M. tuberculosis, in this study, we have constructed five M. tuberculosis H37Rv ESX-5 knockout/deletion mutants, inactivating eccA",

author = "D. Bottai and \{di Luca\}, M. and L. Majlessi and W. Frigui and R. Simeone and F. Sayes and W. Bitter and M.J. Brennan and C. Leclerc and G. Batoni and M. Campa and R. Brosch and S. Esin",

year = "2012",

month = mar,

doi = "10.1111/j.1365-2958.2012.08001.x",

language = "English",

volume = "83",

pages = "1195--1209",

journal = "Molecular Microbiology",

issn = "0950-382X",

publisher = "John Wiley and Sons Inc.",

number = "6",

}

Bottai, D, di Luca, M, Majlessi, L, Frigui, W, Simeone, R, Sayes, F, Bitter, W, Brennan, MJ, Leclerc, C, Batoni, G, Campa, M, Brosch, R & Esin, S 2012, 'Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation.', Molecular Microbiology, vol. 83, no. 6, pp. 1195-1209. https://doi.org/10.1111/j.1365-2958.2012.08001.x

TY - JOUR

T1 - Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation.

AU - Bottai, D.

AU - di Luca, M.

AU - Majlessi, L.

AU - Frigui, W.

AU - Simeone, R.

AU - Sayes, F.

AU - Bitter, W.

AU - Brennan, M.J.

AU - Leclerc, C.

AU - Batoni, G.

AU - Campa, M.

AU - Brosch, R.

AU - Esin, S.

PY - 2012/3

Y1 - 2012/3

N2 - The chromosome of Mycobacterium tuberculosis encodes five type VII secretion systems (ESX-1-ESX-5). While the role of the ESX-1 and ESX-3 systems in M. tuberculosis has been elucidated, predictions for the function of the ESX-5 system came from data obtained in Mycobacterium marinum, where it transports PPE and PE-PGRS proteins and modulates innate immune responses. To define the role of the ESX-5 system in M. tuberculosis, in this study, we have constructed five M. tuberculosis H37Rv ESX-5 knockout/deletion mutants, inactivating eccA

AB - The chromosome of Mycobacterium tuberculosis encodes five type VII secretion systems (ESX-1-ESX-5). While the role of the ESX-1 and ESX-3 systems in M. tuberculosis has been elucidated, predictions for the function of the ESX-5 system came from data obtained in Mycobacterium marinum, where it transports PPE and PE-PGRS proteins and modulates innate immune responses. To define the role of the ESX-5 system in M. tuberculosis, in this study, we have constructed five M. tuberculosis H37Rv ESX-5 knockout/deletion mutants, inactivating eccA

U2 - 10.1111/j.1365-2958.2012.08001.x

DO - 10.1111/j.1365-2958.2012.08001.x

M3 - Article

SN - 0950-382X

VL - 83

SP - 1195

EP - 1209

JO - Molecular Microbiology

JF - Molecular Microbiology

IS - 6

ER -

Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation.

Abstract

UN SDGs

Access to Document

Persistent URL (handle)

Fingerprint

Cite this