Distinct cardiotoxic effects by venoms of a spitting cobra (Naja pallida) and a rattlesnake (Crotalus atrox) revealed using an ex vivo Langendorff heart model

Ronald Vlasblom; Jory van Thiel; Mátyás A. Bittenbinder; Jon Ruben van Rhijn; Rinske Drost; Lotte Muis; Julien Slagboom; Daniela Salvatori; Jeroen Kool; Robert Jan Veldman

doi:10.1016/j.toxicon.2024.107637

Distinct cardiotoxic effects by venoms of a spitting cobra (Naja pallida) and a rattlesnake (Crotalus atrox) revealed using an ex vivo Langendorff heart model

Ronald Vlasblom^*
, Jory van Thiel
, Mátyás A. Bittenbinder
, Jon Ruben van Rhijn
, Rinske Drost
, Lotte Muis
, Julien Slagboom
, Daniela Salvatori
, Jeroen Kool
, Robert Jan Veldman

^*Corresponding author for this work

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Here we describe the acute myocardial effects of an elapid (red spitting cobra, Naja pallida) and a viper (western diamondback rattlesnake, Crotalus atrox) venom using an ex vivo heart model. Our results reveal two different pathophysiological trajectories that influence heart function and morphology. While cobra venom causes a drop in contractile force, rattlesnake venom causes enhanced contractility and frequency that coincides with differences in myocellular morphology. This highlights the medical complexity of snake venom-induced cardiotoxicity.

Original language	English
Article number	107637
Pages (from-to)	1-5
Number of pages	5
Journal	Toxicon
Volume	240
Early online date	6 Feb 2024
DOIs	https://doi.org/10.1016/j.toxicon.2024.107637
Publication status	Published - Mar 2024

Bibliographical note

Publisher Copyright:
© 2024 The Authors

Funding

The silhouettes of the snakes in the graphical abstract were created by Gabriela Palomo-Munoz (Crotalus) and by V Deepak (Naja)

Keywords

Cardiotoxicity
Cardiovascular system
Langendorff heart
Snakebite
Venom

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10.1016/j.toxicon.2024.107637

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Vlasblom, R., van Thiel, J., Bittenbinder, M. A., van Rhijn, J. R., Drost, R., Muis, L., Slagboom, J., Salvatori, D., Kool, J., & Veldman, R. J. (2024). Distinct cardiotoxic effects by venoms of a spitting cobra (Naja pallida) and a rattlesnake (Crotalus atrox) revealed using an ex vivo Langendorff heart model. Toxicon, 240, 1-5. Article 107637. https://doi.org/10.1016/j.toxicon.2024.107637

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title = "Distinct cardiotoxic effects by venoms of a spitting cobra (Naja pallida) and a rattlesnake (Crotalus atrox) revealed using an ex vivo Langendorff heart model",

abstract = "Here we describe the acute myocardial effects of an elapid (red spitting cobra, Naja pallida) and a viper (western diamondback rattlesnake, Crotalus atrox) venom using an ex vivo heart model. Our results reveal two different pathophysiological trajectories that influence heart function and morphology. While cobra venom causes a drop in contractile force, rattlesnake venom causes enhanced contractility and frequency that coincides with differences in myocellular morphology. This highlights the medical complexity of snake venom-induced cardiotoxicity.",

keywords = "Cardiotoxicity, Cardiovascular system, Langendorff heart, Snakebite, Venom",

author = "Ronald Vlasblom and \{van Thiel\}, Jory and Bittenbinder, \{M{\'a}ty{\'a}s A.\} and \{van Rhijn\}, \{Jon Ruben\} and Rinske Drost and Lotte Muis and Julien Slagboom and Daniela Salvatori and Jeroen Kool and Veldman, \{Robert Jan\}",

note = "Publisher Copyright: {\textcopyright} 2024 The Authors",

year = "2024",

month = mar,

doi = "10.1016/j.toxicon.2024.107637",

language = "English",

volume = "240",

pages = "1--5",

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Vlasblom, R, van Thiel, J, Bittenbinder, MA, van Rhijn, JR, Drost, R, Muis, L, Slagboom, J, Salvatori, D, Kool, J & Veldman, RJ 2024, 'Distinct cardiotoxic effects by venoms of a spitting cobra (Naja pallida) and a rattlesnake (Crotalus atrox) revealed using an ex vivo Langendorff heart model', Toxicon, vol. 240, 107637, pp. 1-5. https://doi.org/10.1016/j.toxicon.2024.107637

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T1 - Distinct cardiotoxic effects by venoms of a spitting cobra (Naja pallida) and a rattlesnake (Crotalus atrox) revealed using an ex vivo Langendorff heart model

AU - Vlasblom, Ronald

AU - van Thiel, Jory

AU - Bittenbinder, Mátyás A.

AU - van Rhijn, Jon Ruben

AU - Drost, Rinske

AU - Muis, Lotte

AU - Slagboom, Julien

AU - Salvatori, Daniela

AU - Kool, Jeroen

AU - Veldman, Robert Jan

PY - 2024/3

Y1 - 2024/3

N2 - Here we describe the acute myocardial effects of an elapid (red spitting cobra, Naja pallida) and a viper (western diamondback rattlesnake, Crotalus atrox) venom using an ex vivo heart model. Our results reveal two different pathophysiological trajectories that influence heart function and morphology. While cobra venom causes a drop in contractile force, rattlesnake venom causes enhanced contractility and frequency that coincides with differences in myocellular morphology. This highlights the medical complexity of snake venom-induced cardiotoxicity.

AB - Here we describe the acute myocardial effects of an elapid (red spitting cobra, Naja pallida) and a viper (western diamondback rattlesnake, Crotalus atrox) venom using an ex vivo heart model. Our results reveal two different pathophysiological trajectories that influence heart function and morphology. While cobra venom causes a drop in contractile force, rattlesnake venom causes enhanced contractility and frequency that coincides with differences in myocellular morphology. This highlights the medical complexity of snake venom-induced cardiotoxicity.

KW - Cardiotoxicity

KW - Cardiovascular system

KW - Langendorff heart

KW - Snakebite

KW - Venom

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DO - 10.1016/j.toxicon.2024.107637

M3 - Article

AN - SCOPUS:85184598159

SN - 0041-0101

VL - 240

SP - 1

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JO - Toxicon

JF - Toxicon

M1 - 107637

ER -

Distinct cardiotoxic effects by venoms of a spitting cobra (Naja pallida) and a rattlesnake (Crotalus atrox) revealed using an ex vivo Langendorff heart model

Abstract

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