Distinct requirements for translocation of the N-tail and C-tail of the Escherichia coli inner membrane protein CyoA.

D.W. van Bloois, G.J. Haan, J.-W. de Gier, B. Oudega, S. Luirink

Research output: Contribution to JournalArticleAcademic

Abstract

Inner membrane proteins (IMPs) of Escherichia coli use different pathways for membrane targeting and integration. YidC plays an essential but poorly defined role in the integration and folding of IMPs both in conjunction with the Sec translocon and as a Sec-independent insertase. Depletion of YidC only marginally affects the insertion of Sec-dependent IMPs, whereas it blocks the insertion of a subset of Sec-independent IMPs. Substrates of this latter "YidC-only" pathway include the relatively small IMPs M13 procoat, Pf3 coat protein, and subunit c of the F
Original languageEnglish
JournalJournal of Biological Chemistry
Volume14
Issue number281
DOIs
Publication statusPublished - 2006

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Escherichia coli
Membrane Proteins
Protein Subunits
Capsid Proteins
Membranes
Substrates

Cite this

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title = "Distinct requirements for translocation of the N-tail and C-tail of the Escherichia coli inner membrane protein CyoA.",
abstract = "Inner membrane proteins (IMPs) of Escherichia coli use different pathways for membrane targeting and integration. YidC plays an essential but poorly defined role in the integration and folding of IMPs both in conjunction with the Sec translocon and as a Sec-independent insertase. Depletion of YidC only marginally affects the insertion of Sec-dependent IMPs, whereas it blocks the insertion of a subset of Sec-independent IMPs. Substrates of this latter {"}YidC-only{"} pathway include the relatively small IMPs M13 procoat, Pf3 coat protein, and subunit c of the F",
author = "{van Bloois}, D.W. and G.J. Haan and {de Gier}, J.-W. and B. Oudega and S. Luirink",
year = "2006",
doi = "10.1074/jbc.M511357200",
language = "English",
volume = "14",
journal = "Journal of Biological Chemistry",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology Inc.",
number = "281",

}

Distinct requirements for translocation of the N-tail and C-tail of the Escherichia coli inner membrane protein CyoA. / van Bloois, D.W.; Haan, G.J.; de Gier, J.-W.; Oudega, B.; Luirink, S.

In: Journal of Biological Chemistry, Vol. 14, No. 281, 2006.

Research output: Contribution to JournalArticleAcademic

TY - JOUR

T1 - Distinct requirements for translocation of the N-tail and C-tail of the Escherichia coli inner membrane protein CyoA.

AU - van Bloois, D.W.

AU - Haan, G.J.

AU - de Gier, J.-W.

AU - Oudega, B.

AU - Luirink, S.

PY - 2006

Y1 - 2006

N2 - Inner membrane proteins (IMPs) of Escherichia coli use different pathways for membrane targeting and integration. YidC plays an essential but poorly defined role in the integration and folding of IMPs both in conjunction with the Sec translocon and as a Sec-independent insertase. Depletion of YidC only marginally affects the insertion of Sec-dependent IMPs, whereas it blocks the insertion of a subset of Sec-independent IMPs. Substrates of this latter "YidC-only" pathway include the relatively small IMPs M13 procoat, Pf3 coat protein, and subunit c of the F

AB - Inner membrane proteins (IMPs) of Escherichia coli use different pathways for membrane targeting and integration. YidC plays an essential but poorly defined role in the integration and folding of IMPs both in conjunction with the Sec translocon and as a Sec-independent insertase. Depletion of YidC only marginally affects the insertion of Sec-dependent IMPs, whereas it blocks the insertion of a subset of Sec-independent IMPs. Substrates of this latter "YidC-only" pathway include the relatively small IMPs M13 procoat, Pf3 coat protein, and subunit c of the F

U2 - 10.1074/jbc.M511357200

DO - 10.1074/jbc.M511357200

M3 - Article

VL - 14

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

SN - 0021-9258

IS - 281

ER -