Distinct requirements for translocation of the N-tail and C-tail of the Escherichia coli inner membrane protein CyoA.

D.W. van Bloois, G.J. Haan, J.-W. de Gier, B. Oudega, S. Luirink

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Abstract

Inner membrane proteins (IMPs) of Escherichia coli use different pathways for membrane targeting and integration. YidC plays an essential but poorly defined role in the integration and folding of IMPs both in conjunction with the Sec translocon and as a Sec-independent insertase. Depletion of YidC only marginally affects the insertion of Sec-dependent IMPs, whereas it blocks the insertion of a subset of Sec-independent IMPs. Substrates of this latter "YidC-only" pathway include the relatively small IMPs M13 procoat, Pf3 coat protein, and subunit c of the F
Original languageEnglish
JournalJournal of Biological Chemistry
Volume14
Issue number281
DOIs
Publication statusPublished - 2006

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