DNA Methylation Changes in the IGF1R Gene in Birth Weight Discordant Adult Monozygotic Twins

P.C. Tsai; J. van Dongen; Q. Tan; G. Willemsen; L. Christiansen; D.I. Boomsma; T.D. Spector; A.M. Valdes; J.T. Bell

doi:10.1017/thg.2015.76

DNA Methylation Changes in the IGF1R Gene in Birth Weight Discordant Adult Monozygotic Twins

P.C. Tsai, J. van Dongen, Q. Tan, G. Willemsen, L. Christiansen, D.I. Boomsma, T.D. Spector, A.M. Valdes, J.T. Bell

Biological Psychology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Low birth weight (LBW) can have an impact on health outcomes in later life, especially in relation to pre-disposition to metabolic disease. Several studies suggest that LBW resulting from restricted intrauterine growth leaves a footprint on DNA methylation in utero, and this influence likely persists into adulthood. To investigate this further, we performed epigenome-wide association analyses of blood DNA methylation using Infinium HumanMethylation450 BeadChip profiles in 71 adult monozygotic (MZ) twin pairs who were extremely discordant for birth weight. A signal mapping to the IGF1R gene (cg12562232, p = 2.62 × 10

Original language	English
Pages (from-to)	635-646
Number of pages	12
Journal	Twin Research and Human Genetics
Volume	18
Issue number	6
DOIs	https://doi.org/10.1017/thg.2015.76
Publication status	Published - 2015

Cohort Studies

Netherlands Twin Register (NTR)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1017/thg.2015.76

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title = "DNA Methylation Changes in the IGF1R Gene in Birth Weight Discordant Adult Monozygotic Twins",

abstract = "Low birth weight (LBW) can have an impact on health outcomes in later life, especially in relation to pre-disposition to metabolic disease. Several studies suggest that LBW resulting from restricted intrauterine growth leaves a footprint on DNA methylation in utero, and this influence likely persists into adulthood. To investigate this further, we performed epigenome-wide association analyses of blood DNA methylation using Infinium HumanMethylation450 BeadChip profiles in 71 adult monozygotic (MZ) twin pairs who were extremely discordant for birth weight. A signal mapping to the IGF1R gene (cg12562232, p = 2.62 × 10",

author = "P.C. Tsai and {van Dongen}, J. and Q. Tan and G. Willemsen and L. Christiansen and D.I. Boomsma and T.D. Spector and A.M. Valdes and J.T. Bell",

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doi = "10.1017/thg.2015.76",

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AU - Tsai, P.C.

AU - van Dongen, J.

AU - Tan, Q.

AU - Willemsen, G.

AU - Christiansen, L.

AU - Boomsma, D.I.

AU - Spector, T.D.

AU - Valdes, A.M.

AU - Bell, J.T.

PY - 2015

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AB - Low birth weight (LBW) can have an impact on health outcomes in later life, especially in relation to pre-disposition to metabolic disease. Several studies suggest that LBW resulting from restricted intrauterine growth leaves a footprint on DNA methylation in utero, and this influence likely persists into adulthood. To investigate this further, we performed epigenome-wide association analyses of blood DNA methylation using Infinium HumanMethylation450 BeadChip profiles in 71 adult monozygotic (MZ) twin pairs who were extremely discordant for birth weight. A signal mapping to the IGF1R gene (cg12562232, p = 2.62 × 10

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JF - Twin Research and Human Genetics

IS - 6

ER -

DNA Methylation Changes in the IGF1R Gene in Birth Weight Discordant Adult Monozygotic Twins

Abstract

Cohort Studies

UN SDGs

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