DNA Methylation Changes in the IGF1R Gene in Birth Weight Discordant Adult Monozygotic Twins

P.C. Tsai, J. van Dongen, Q. Tan, G. Willemsen, L. Christiansen, D.I. Boomsma, T.D. Spector, A.M. Valdes, J.T. Bell

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Low birth weight (LBW) can have an impact on health outcomes in later life, especially in relation to pre-disposition to metabolic disease. Several studies suggest that LBW resulting from restricted intrauterine growth leaves a footprint on DNA methylation in utero, and this influence likely persists into adulthood. To investigate this further, we performed epigenome-wide association analyses of blood DNA methylation using Infinium HumanMethylation450 BeadChip profiles in 71 adult monozygotic (MZ) twin pairs who were extremely discordant for birth weight. A signal mapping to the IGF1R gene (cg12562232, p = 2.62 × 10
Original languageEnglish
Pages (from-to)635-646
Number of pages12
JournalTwin Research and Human Genetics
Volume18
Issue number6
DOIs
Publication statusPublished - 2015

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