DNA Methylation Changes in the IGF1R Gene in Birth Weight Discordant Adult Monozygotic Twins

P.C. Tsai; J. van Dongen; Q. Tan; G. Willemsen; L. Christiansen; D.I. Boomsma; T.D. Spector; A.M. Valdes; J.T. Bell

doi:10.1017/thg.2015.76

DNA Methylation Changes in the IGF1R Gene in Birth Weight Discordant Adult Monozygotic Twins

P.C. Tsai
, J. van Dongen
, Q. Tan
, G. Willemsen
, L. Christiansen
, D.I. Boomsma
, T.D. Spector
, A.M. Valdes
, J.T. Bell

Biological Psychology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Low birth weight (LBW) can have an impact on health outcomes in later life, especially in relation to pre-disposition to metabolic disease. Several studies suggest that LBW resulting from restricted intrauterine growth leaves a footprint on DNA methylation in utero, and this influence likely persists into adulthood. To investigate this further, we performed epigenome-wide association analyses of blood DNA methylation using Infinium HumanMethylation450 BeadChip profiles in 71 adult monozygotic (MZ) twin pairs who were extremely discordant for birth weight. A signal mapping to the IGF1R gene (cg12562232, p = 2.62 × 10

Original language	English
Pages (from-to)	635-646
Number of pages	12
Journal	Twin Research and Human Genetics
Volume	18
Issue number	6
DOIs	https://doi.org/10.1017/thg.2015.76
Publication status	Published - 2015

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Cohort Studies

Netherlands Twin Register (NTR)

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10.1017/thg.2015.76

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title = "DNA Methylation Changes in the IGF1R Gene in Birth Weight Discordant Adult Monozygotic Twins",

abstract = "Low birth weight (LBW) can have an impact on health outcomes in later life, especially in relation to pre-disposition to metabolic disease. Several studies suggest that LBW resulting from restricted intrauterine growth leaves a footprint on DNA methylation in utero, and this influence likely persists into adulthood. To investigate this further, we performed epigenome-wide association analyses of blood DNA methylation using Infinium HumanMethylation450 BeadChip profiles in 71 adult monozygotic (MZ) twin pairs who were extremely discordant for birth weight. A signal mapping to the IGF1R gene (cg12562232, p = 2.62 × 10",

author = "P.C. Tsai and \{van Dongen\}, J. and Q. Tan and G. Willemsen and L. Christiansen and D.I. Boomsma and T.D. Spector and A.M. Valdes and J.T. Bell",

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doi = "10.1017/thg.2015.76",

language = "English",

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AU - Tsai, P.C.

AU - van Dongen, J.

AU - Tan, Q.

AU - Willemsen, G.

AU - Christiansen, L.

AU - Boomsma, D.I.

AU - Spector, T.D.

AU - Valdes, A.M.

AU - Bell, J.T.

PY - 2015

Y1 - 2015

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AB - Low birth weight (LBW) can have an impact on health outcomes in later life, especially in relation to pre-disposition to metabolic disease. Several studies suggest that LBW resulting from restricted intrauterine growth leaves a footprint on DNA methylation in utero, and this influence likely persists into adulthood. To investigate this further, we performed epigenome-wide association analyses of blood DNA methylation using Infinium HumanMethylation450 BeadChip profiles in 71 adult monozygotic (MZ) twin pairs who were extremely discordant for birth weight. A signal mapping to the IGF1R gene (cg12562232, p = 2.62 × 10

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DO - 10.1017/thg.2015.76

M3 - Article

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EP - 646

JO - Twin Research and Human Genetics

JF - Twin Research and Human Genetics

IS - 6

ER -

DNA Methylation Changes in the IGF1R Gene in Birth Weight Discordant Adult Monozygotic Twins

Abstract

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