DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan

Jenny van Dongen; Fiona A. Hagenbeek; Matthew Suderman; Peter J. Roetman; Karen Sugden; Andreas G. Chiocchetti; Khadeeja Ismail; Rosa H. Mulder; Jonathan D. Hafferty; Mark J. Adams; Rosie M. Walker; Stewart W. Morris; Jari Lahti; Leanne K. Küpers; Georgia Escaramis; Silvia Alemany; Marc Jan Bonder; Mandy Meijer; Hill F. Ip; Rick Jansen; Bart M. L. Baselmans; Priyanka Parmar; Estelle Lowry; Fabian Streit; Lea Sirignano; Tabea S. Send; Josef Frank; Juulia Jylhävä; Yunzhang Wang; Pashupati Prasad Mishra; Olivier F. Colins; David L. Corcoran; Richie Poulton; Jonathan Mill; Eilis Hannon; Louise Arseneault; Tellervo Korhonen; Eero Vuoksimaa; Janine F. Felix; Marian J. Bakermans-kranenburg; Archie Campbell; Darina Czamara; Elisabeth Binder; Eva Corpeleijn; Juan R. Gonzalez; Regina Grazuleviciene; Kristine B. Gutzkow; Jorunn Evandt; Marina Vafeiadi; Marieke Klein; Dennis Van Der Meer; Lannie Ligthart; Cornelis Kluft; Gareth E. Davies; Christian Hakulinen; Liisa Keltikangas-järvinen; Barbara Franke; Christine M. Freitag; Kerstin Konrad; Amaia Hervas; Aranzazu Fernández-rivas; Agnes Vetro; Olli Raitakari; Terho Lehtimäki; Robert Vermeiren; Timo Strandberg; Katri Räikkönen; Harold Snieder; Stephanie H. Witt; Michael Deuschle; Nancy L. Pedersen; Sara Hägg; Jordi Sunyer; Lude Franke; Jaakko Kaprio; Miina Ollikainen; Terrie E. Moffitt; Henning Tiemeier; Marinus H. Van Ijzendoorn; Caroline Relton; Martine Vrijheid; Sylvain Sebert; Marjo-riitta Jarvelin; Avshalom Caspi; Kathryn L. Evans; Andrew M. Mcintosh; Meike Bartels; Dorret I. Boomsma

doi:10.1038/s41380-020-00987-x

DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan

Jenny van Dongen, Fiona A. Hagenbeek, Matthew Suderman, Peter J. Roetman, Karen Sugden, Andreas G. Chiocchetti, Khadeeja Ismail, Rosa H. Mulder, Jonathan D. Hafferty, Mark J. Adams, Rosie M. Walker, Stewart W. Morris, Jari Lahti, Leanne K. Küpers, Georgia Escaramis, Silvia Alemany, Marc Jan Bonder, Mandy Meijer, Hill F. Ip, Rick JansenBart M. L. Baselmans, Priyanka Parmar, Estelle Lowry, Fabian Streit, Lea Sirignano, Tabea S. Send, Josef Frank, Juulia Jylhävä, Yunzhang Wang, Pashupati Prasad Mishra, Olivier F. Colins, David L. Corcoran, Richie Poulton, Jonathan Mill, Eilis Hannon, Louise Arseneault, Tellervo Korhonen, Eero Vuoksimaa, Janine F. Felix, Marian J. Bakermans-kranenburg, Archie Campbell, Darina Czamara, Elisabeth Binder, Eva Corpeleijn, Juan R. Gonzalez, Regina Grazuleviciene, Kristine B. Gutzkow, Jorunn Evandt, Marina Vafeiadi, Marieke Klein, Dennis Van Der Meer, Lannie Ligthart, Cornelis Kluft, Gareth E. Davies, Christian Hakulinen, Liisa Keltikangas-järvinen, Barbara Franke, Christine M. Freitag, Kerstin Konrad, Amaia Hervas, Aranzazu Fernández-rivas, Agnes Vetro, Olli Raitakari, Terho Lehtimäki, Robert Vermeiren, Timo Strandberg, Katri Räikkönen, Harold Snieder, Stephanie H. Witt, Michael Deuschle, Nancy L. Pedersen, Sara Hägg, Jordi Sunyer, Lude Franke, Jaakko Kaprio, Miina Ollikainen, Terrie E. Moffitt, Henning Tiemeier, Marinus H. Van Ijzendoorn, Caroline Relton, Martine Vrijheid, Sylvain Sebert, Marjo-riitta Jarvelin, Avshalom Caspi, Kathryn L. Evans, Andrew M. Mcintosh, Meike Bartels, Dorret I. Boomsma

Research output: Contribution to Journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	2148-2162
Number of pages	15
Journal	Molecular Psychiatry
Volume	26
Issue number	6
Early online date	8 Jan 2021
DOIs	https://doi.org/10.1038/s41380-020-00987-x
Publication status	Published - Jun 2021

Funding

Acknowledgements This work was supported by ACTION. ACTION receives funding from the European Union Seventh Framework Conflict of interest The following authors declare a conflict of interest: BF received educational speaking fees from Medice. AMM has received research support from Eli Lilly, Janssen, and The Sackler Trust and speaker fees from Illumina and Janssen. CMF has received funding by the DFG, BMBF, State of Hessen, and the EU. She receives royalties for books on ASD, ADHD, and MDD. The other authors declare that they have no conflict of interest. Program (FP7/2007–2013) under grant agreement no 602768. Cohort-specific acknowledgements are provided in eAppendix 1.

Funders	Funder number
ACTION
National Institute of Mental Health	R01MH062873
Eli Lilly and Company
Janssen Pharmaceuticals
Seventh Framework Programme	602768
Sackler Trust
European Commission
Deutsche Forschungsgemeinschaft
Bundesministerium für Bildung und Forschung
Seventh Framework Programme

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41380-020-00987-x

http://www.nature.com/articles/s41380-020-00987-x

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Cite this

van Dongen, J., Hagenbeek, F. A., Suderman, M., Roetman, P. J., Sugden, K., Chiocchetti, A. G., Ismail, K., Mulder, R. H., Hafferty, J. D., Adams, M. J., Walker, R. M., Morris, S. W., Lahti, J., Küpers, L. K., Escaramis, G., Alemany, S., Jan Bonder, M., Meijer, M., Ip, H. F., ... Boomsma, D. I. (2021). DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan. Molecular Psychiatry, 26(6), 2148-2162. https://doi.org/10.1038/s41380-020-00987-x

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van Dongen, J , Hagenbeek, FA, Suderman, M, Roetman, PJ, Sugden, K, Chiocchetti, AG, Ismail, K, Mulder, RH, Hafferty, JD, Adams, MJ, Walker, RM, Morris, SW, Lahti, J, Küpers, LK, Escaramis, G, Alemany, S, Jan Bonder, M, Meijer, M, Ip, HF, Jansen, R, Baselmans, BML, Parmar, P, Lowry, E, Streit, F, Sirignano, L, Send, TS, Frank, J, Jylhävä, J, Wang, Y, Mishra, PP, Colins, OF, Corcoran, DL, Poulton, R, Mill, J, Hannon, E, Arseneault, L, Korhonen, T, Vuoksimaa, E, Felix, JF, Bakermans-kranenburg, MJ, Campbell, A, Czamara, D, Binder, E, Corpeleijn, E, Gonzalez, JR, Grazuleviciene, R, Gutzkow, KB, Evandt, J, Vafeiadi, M, Klein, M, Van Der Meer, D, Ligthart, L, Kluft, C, Davies, GE, Hakulinen, C, Keltikangas-järvinen, L, Franke, B, Freitag, CM, Konrad, K, Hervas, A, Fernández-rivas, A, Vetro, A, Raitakari, O, Lehtimäki, T, Vermeiren, R, Strandberg, T, Räikkönen, K, Snieder, H, Witt, SH, Deuschle, M, Pedersen, NL, Hägg, S, Sunyer, J, Franke, L, Kaprio, J, Ollikainen, M, Moffitt, TE, Tiemeier, H, Van Ijzendoorn, MH, Relton, C, Vrijheid, M, Sebert, S, Jarvelin, M, Caspi, A, Evans, KL, Mcintosh, AM, Bartels, M & Boomsma, DI 2021, 'DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan', Molecular Psychiatry, vol. 26, no. 6, pp. 2148-2162. https://doi.org/10.1038/s41380-020-00987-x

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AU - Hagenbeek, Fiona A.

AU - Suderman, Matthew

AU - Roetman, Peter J.

AU - Sugden, Karen

AU - Chiocchetti, Andreas G.

AU - Ismail, Khadeeja

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AU - Hafferty, Jonathan D.

AU - Adams, Mark J.

AU - Walker, Rosie M.

AU - Morris, Stewart W.

AU - Lahti, Jari

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AU - Ip, Hill F.

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AU - Parmar, Priyanka

AU - Lowry, Estelle

AU - Streit, Fabian

AU - Sirignano, Lea

AU - Send, Tabea S.

AU - Frank, Josef

AU - Jylhävä, Juulia

AU - Wang, Yunzhang

AU - Mishra, Pashupati Prasad

AU - Colins, Olivier F.

AU - Corcoran, David L.

AU - Poulton, Richie

AU - Mill, Jonathan

AU - Hannon, Eilis

AU - Arseneault, Louise

AU - Korhonen, Tellervo

AU - Vuoksimaa, Eero

AU - Felix, Janine F.

AU - Bakermans-kranenburg, Marian J.

AU - Campbell, Archie

AU - Czamara, Darina

AU - Binder, Elisabeth

AU - Corpeleijn, Eva

AU - Gonzalez, Juan R.

AU - Grazuleviciene, Regina

AU - Gutzkow, Kristine B.

AU - Evandt, Jorunn

AU - Vafeiadi, Marina

AU - Klein, Marieke

AU - Van Der Meer, Dennis

AU - Ligthart, Lannie

AU - Kluft, Cornelis

AU - Davies, Gareth E.

AU - Hakulinen, Christian

AU - Keltikangas-järvinen, Liisa

AU - Franke, Barbara

AU - Freitag, Christine M.

AU - Konrad, Kerstin

AU - Hervas, Amaia

AU - Fernández-rivas, Aranzazu

AU - Vetro, Agnes

AU - Raitakari, Olli

AU - Lehtimäki, Terho

AU - Vermeiren, Robert

AU - Strandberg, Timo

AU - Räikkönen, Katri

AU - Snieder, Harold

AU - Witt, Stephanie H.

AU - Deuschle, Michael

AU - Pedersen, Nancy L.

AU - Hägg, Sara

AU - Sunyer, Jordi

AU - Franke, Lude

AU - Kaprio, Jaakko

AU - Ollikainen, Miina

AU - Moffitt, Terrie E.

AU - Tiemeier, Henning

AU - Van Ijzendoorn, Marinus H.

AU - Relton, Caroline

AU - Vrijheid, Martine

AU - Sebert, Sylvain

AU - Jarvelin, Marjo-riitta

AU - Caspi, Avshalom

AU - Evans, Kathryn L.

AU - Mcintosh, Andrew M.

AU - Bartels, Meike

AU - Boomsma, Dorret I.

PY - 2021/6

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DO - 10.1038/s41380-020-00987-x

M3 - Article

SN - 1359-4184

VL - 26

SP - 2148

EP - 2162

JO - Molecular Psychiatry

JF - Molecular Psychiatry

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