DNA methylation signatures of educational attainment

Jenny van Dongen, Marc Jan Bonder, Koen F. Dekkers, Michel G. Nivard, Maarten van Iterson, Gonneke Willemsen, Marian Beekman, Ashley van der Spek, Joyce B. J. van Meurs, Lude Franke, Bastiaan T. Heijmans, Cornelia M. van Duijn, P. Eline Slagboom, Dorret I. Boomsma

Research output: Contribution to JournalArticleAcademicpeer-review


Educational attainment is a key behavioural measure in studies of cognitive and physical health, and socioeconomic status. We measured DNA methylation at 410,746 CpGs (N = 4152) and identified 58 CpGs associated with educational attainment at loci characterized by pleiotropic functions shared with neuronal, immune and developmental processes. Associations overlapped with those for smoking behaviour, but remained after accounting for smoking at many CpGs: Effect sizes were on average 28% smaller and genome-wide significant at 11 CpGs after adjusting for smoking and were 62% smaller in never smokers. We examined sources and biological implications of education-related methylation differences, demonstrating correlations with maternal prenatal folate, smoking and air pollution signatures, and associations with gene expression in cis, dynamic methylation in foetal brain, and correlations between blood and brain. Our findings show that the methylome of lower-educated people resembles that of smokers beyond effects of their own smoking behaviour and shows traces of various other exposures.
Original languageEnglish
Article number7
Pages (from-to)1-14
Number of pages14
Journalnpj Science of Learning
Issue number1
Publication statusPublished - 23 Mar 2018


  • Education
  • Epigenetics and behaviour
  • Human behaviour

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