Do dental parameters predict severity of obstructive sleep apnea and mandibular advancement device therapy outcomes? A pilot study

Julia Anne Margarethe Uniken Venema; Pien Fenneke Nicole Bosschieter; Aarnoud Hoekema; Joanneke Marielle Plooij; Frank Lobbezoo; Nico de Vries

doi:10.1111/joor.13392

Do dental parameters predict severity of obstructive sleep apnea and mandibular advancement device therapy outcomes? A pilot study

Julia Anne Margarethe Uniken Venema^*, Pien Fenneke Nicole Bosschieter, Aarnoud Hoekema, Joanneke Marielle Plooij, Frank Lobbezoo, Nico de Vries

^*Corresponding author for this work

Oral Kinesiology

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Background: Mandibular Advancement Devices (MAD's) are oral appliances commonly used in treatment of Obstructive Sleep Apnea (OSA). OSA severity and certain other factors, such as BMI and neck circumference, correlate with MAD therapy success. So far, the predictive value of dental parameters, such as dental profile, molar-classification, overjet, overbite, maximal retrusion, maximal protrusion and protrusive range, has not been fully investigated. Objectives: We aimed to investigate whether dental parameters influence OSA severity and MAD therapy outcome and could therefore be helpful in phenotyping OSA patients. Furthermore, we studied the predictive power of dental parameters for OSA severity and successful MAD therapy. We hypothesise that specific dental parameters correlate with more severe OSA and with more successful MAD treatment. Methods: We performed a cohort study, including OSA patients diagnosed by polysomnography (PSG). Dental parameters were collected. Objective treatment outcome was collected by performing a PSG with MAD after three months of therapy. Differences between OSA severity groups and MAD treatment outcomes were analysed and dental parameters were correlated between groups. Results: The relation between dental parameters and OSA severity was analysed in 143 patients, fifty patients had a PSG with MAD in situ after a 3-month therapy. The median baseline Apnea Hypopnea Index (AHI) significantly reduced from 17.6 (8.7–29.3) to 11.1 (5.5–17.5). Overbite and maximal retrusion differed significantly between mild, moderate and severe OSA. Other dental parameters did not differ significantly between the groups, nor correlated with OSA severity or MAD treatment outcome. Conclusion: In this study, no correlation between dental parameters and OSA severity or MAD treatment outcomes was found. Therefore, screening patients for OSA and MAD treatment outcome based on dental parameters is currently not possible.

Original language	English
Pages (from-to)	203-209
Number of pages	7
Journal	Journal of Oral Rehabilitation
Volume	50
Issue number	3
Early online date	10 Nov 2022
DOIs	https://doi.org/10.1111/joor.13392
Publication status	Published - Mar 2023

Bibliographical note

Funding Information:
All authors have read and approved the manuscript. The authors affirm that this is an original manuscript, is unpublished work and is not under consideration elsewhere. This research was financially supported by Airway Management Inc. (no grand number given). This research was performed at the Onze Lieve Vrouwe Gasthuis (OLVG), Amsterdam, the Netherlands. Data are available upon reasonable request to the corresponding author.

Publisher Copyright:
© 2022 The Authors. Journal of Oral Rehabilitation published by John Wiley & Sons Ltd.

Keywords

mandibular advancement device (MAD)
obstructive sleep apnea (OSA)
polysomnography (PSG)
treatment outcome

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/joor.13392

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@article{0f2cc7dc944542519eaebf4eb1106b32,

title = "Do dental parameters predict severity of obstructive sleep apnea and mandibular advancement device therapy outcomes? A pilot study",

abstract = "Background: Mandibular Advancement Devices (MAD's) are oral appliances commonly used in treatment of Obstructive Sleep Apnea (OSA). OSA severity and certain other factors, such as BMI and neck circumference, correlate with MAD therapy success. So far, the predictive value of dental parameters, such as dental profile, molar-classification, overjet, overbite, maximal retrusion, maximal protrusion and protrusive range, has not been fully investigated. Objectives: We aimed to investigate whether dental parameters influence OSA severity and MAD therapy outcome and could therefore be helpful in phenotyping OSA patients. Furthermore, we studied the predictive power of dental parameters for OSA severity and successful MAD therapy. We hypothesise that specific dental parameters correlate with more severe OSA and with more successful MAD treatment. Methods: We performed a cohort study, including OSA patients diagnosed by polysomnography (PSG). Dental parameters were collected. Objective treatment outcome was collected by performing a PSG with MAD after three months of therapy. Differences between OSA severity groups and MAD treatment outcomes were analysed and dental parameters were correlated between groups. Results: The relation between dental parameters and OSA severity was analysed in 143 patients, fifty patients had a PSG with MAD in situ after a 3-month therapy. The median baseline Apnea Hypopnea Index (AHI) significantly reduced from 17.6 (8.7–29.3) to 11.1 (5.5–17.5). Overbite and maximal retrusion differed significantly between mild, moderate and severe OSA. Other dental parameters did not differ significantly between the groups, nor correlated with OSA severity or MAD treatment outcome. Conclusion: In this study, no correlation between dental parameters and OSA severity or MAD treatment outcomes was found. Therefore, screening patients for OSA and MAD treatment outcome based on dental parameters is currently not possible.",

keywords = "mandibular advancement device (MAD), obstructive sleep apnea (OSA), polysomnography (PSG), treatment outcome",

author = "{Uniken Venema}, {Julia Anne Margarethe} and Bosschieter, {Pien Fenneke Nicole} and Aarnoud Hoekema and Plooij, {Joanneke Marielle} and Frank Lobbezoo and {de Vries}, Nico",

note = "Funding Information: All authors have read and approved the manuscript. The authors affirm that this is an original manuscript, is unpublished work and is not under consideration elsewhere. This research was financially supported by Airway Management Inc. (no grand number given). This research was performed at the Onze Lieve Vrouwe Gasthuis (OLVG), Amsterdam, the Netherlands. Data are available upon reasonable request to the corresponding author. Publisher Copyright: {\textcopyright} 2022 The Authors. Journal of Oral Rehabilitation published by John Wiley & Sons Ltd.",

year = "2023",

month = mar,

doi = "10.1111/joor.13392",

language = "English",

volume = "50",

pages = "203--209",

journal = "Journal of Oral Rehabilitation",

issn = "0305-182X",

publisher = "Wiley-Blackwell",

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}

Do dental parameters predict severity of obstructive sleep apnea and mandibular advancement device therapy outcomes? A pilot study. / Uniken Venema, Julia Anne Margarethe; Bosschieter, Pien Fenneke Nicole; Hoekema, Aarnoud et al.
In: Journal of Oral Rehabilitation, Vol. 50, No. 3, 03.2023, p. 203-209.

Research output: Contribution to Journal › Article › Academic › peer-review

TY - JOUR

T1 - Do dental parameters predict severity of obstructive sleep apnea and mandibular advancement device therapy outcomes? A pilot study

AU - Uniken Venema, Julia Anne Margarethe

AU - Bosschieter, Pien Fenneke Nicole

AU - Hoekema, Aarnoud

AU - Plooij, Joanneke Marielle

AU - Lobbezoo, Frank

AU - de Vries, Nico

N1 - Funding Information: All authors have read and approved the manuscript. The authors affirm that this is an original manuscript, is unpublished work and is not under consideration elsewhere. This research was financially supported by Airway Management Inc. (no grand number given). This research was performed at the Onze Lieve Vrouwe Gasthuis (OLVG), Amsterdam, the Netherlands. Data are available upon reasonable request to the corresponding author. Publisher Copyright: © 2022 The Authors. Journal of Oral Rehabilitation published by John Wiley & Sons Ltd.

PY - 2023/3

Y1 - 2023/3

N2 - Background: Mandibular Advancement Devices (MAD's) are oral appliances commonly used in treatment of Obstructive Sleep Apnea (OSA). OSA severity and certain other factors, such as BMI and neck circumference, correlate with MAD therapy success. So far, the predictive value of dental parameters, such as dental profile, molar-classification, overjet, overbite, maximal retrusion, maximal protrusion and protrusive range, has not been fully investigated. Objectives: We aimed to investigate whether dental parameters influence OSA severity and MAD therapy outcome and could therefore be helpful in phenotyping OSA patients. Furthermore, we studied the predictive power of dental parameters for OSA severity and successful MAD therapy. We hypothesise that specific dental parameters correlate with more severe OSA and with more successful MAD treatment. Methods: We performed a cohort study, including OSA patients diagnosed by polysomnography (PSG). Dental parameters were collected. Objective treatment outcome was collected by performing a PSG with MAD after three months of therapy. Differences between OSA severity groups and MAD treatment outcomes were analysed and dental parameters were correlated between groups. Results: The relation between dental parameters and OSA severity was analysed in 143 patients, fifty patients had a PSG with MAD in situ after a 3-month therapy. The median baseline Apnea Hypopnea Index (AHI) significantly reduced from 17.6 (8.7–29.3) to 11.1 (5.5–17.5). Overbite and maximal retrusion differed significantly between mild, moderate and severe OSA. Other dental parameters did not differ significantly between the groups, nor correlated with OSA severity or MAD treatment outcome. Conclusion: In this study, no correlation between dental parameters and OSA severity or MAD treatment outcomes was found. Therefore, screening patients for OSA and MAD treatment outcome based on dental parameters is currently not possible.

AB - Background: Mandibular Advancement Devices (MAD's) are oral appliances commonly used in treatment of Obstructive Sleep Apnea (OSA). OSA severity and certain other factors, such as BMI and neck circumference, correlate with MAD therapy success. So far, the predictive value of dental parameters, such as dental profile, molar-classification, overjet, overbite, maximal retrusion, maximal protrusion and protrusive range, has not been fully investigated. Objectives: We aimed to investigate whether dental parameters influence OSA severity and MAD therapy outcome and could therefore be helpful in phenotyping OSA patients. Furthermore, we studied the predictive power of dental parameters for OSA severity and successful MAD therapy. We hypothesise that specific dental parameters correlate with more severe OSA and with more successful MAD treatment. Methods: We performed a cohort study, including OSA patients diagnosed by polysomnography (PSG). Dental parameters were collected. Objective treatment outcome was collected by performing a PSG with MAD after three months of therapy. Differences between OSA severity groups and MAD treatment outcomes were analysed and dental parameters were correlated between groups. Results: The relation between dental parameters and OSA severity was analysed in 143 patients, fifty patients had a PSG with MAD in situ after a 3-month therapy. The median baseline Apnea Hypopnea Index (AHI) significantly reduced from 17.6 (8.7–29.3) to 11.1 (5.5–17.5). Overbite and maximal retrusion differed significantly between mild, moderate and severe OSA. Other dental parameters did not differ significantly between the groups, nor correlated with OSA severity or MAD treatment outcome. Conclusion: In this study, no correlation between dental parameters and OSA severity or MAD treatment outcomes was found. Therefore, screening patients for OSA and MAD treatment outcome based on dental parameters is currently not possible.

KW - mandibular advancement device (MAD)

KW - obstructive sleep apnea (OSA)

KW - polysomnography (PSG)

KW - treatment outcome

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SN - 0305-182X

VL - 50

SP - 203

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JO - Journal of Oral Rehabilitation

JF - Journal of Oral Rehabilitation

IS - 3

ER -

Do dental parameters predict severity of obstructive sleep apnea and mandibular advancement device therapy outcomes? A pilot study

Abstract

Bibliographical note

Keywords

UN SDGs

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