DOC2 isoforms play dual roles in insulin secretion and insulin-stimulated glucose uptake

J. Li, J. Cantley, J.G. Burchfield, C.C. Meoli, J. Stöckli, P.T. Whitworth, H. Pant, R. Chaudhuri, A.J.A. Groffen, M. Verhage, D.E. James

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Aims/hypothesis Glucose-stimulated insulin secretion (GSIS) and insulin-stimulated glucose uptake are processes that rely on regulated intracellular vesicle transport and vesicle fusion with the plasma membrane. DOC2A and DOC2B are calcium-sensitive proteins that were identified as key components of vesicle exocytosis in neurons. Our aim was to investigate the role of DOC2 isoforms in glucose homeostasis, insulin secretion and insulin action. Methods DOC2 expression was measured by RT-PCR and western blotting. Body weight, glucose tolerance, insulin action and GSIS were assessed in wild-type (WT), Doc2a
Original languageEnglish
Pages (from-to)2173-2182
JournalDiabetologia
Volume57
Issue number10
DOIs
Publication statusPublished - 2014

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