Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter release

A.J.A. Groffen; S. Martens; R. Diez Arazola; L.N. Cornelisse; N. Lozovaya; A.P.H. de Jong; N.A. Goriounova; R.L. Habets; Y. Takai; J.G. Borst; N. Brose; H.T. McMahon; M. Verhage

doi:10.1126/science.1183765

Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter release

A.J.A. Groffen, S. Martens, R. Diez Arazola, L.N. Cornelisse, N. Lozovaya, A.P.H. de Jong, N.A. Goriounova, R.L. Habets, Y. Takai, J.G. Borst, N. Brose, H.T. McMahon, M. Verhage

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Synaptic vesicle fusion in brain synapses occurs in phases that are either tightly coupled to action potentials (synchronous), immediately following action potentials (asynchronous), or as stochastic events in the absence of action potentials (spontaneous). Synaptotagmin-1, -2, and -9 are vesicleassociated Ca

Original language	English
Pages (from-to)	1614-1618
Number of pages	4
Journal	Science
Volume	327
Issue number	5973
DOIs	https://doi.org/10.1126/science.1183765
Publication status	Published - 2010

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10.1126/science.1183765

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title = "Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter release",

abstract = "Synaptic vesicle fusion in brain synapses occurs in phases that are either tightly coupled to action potentials (synchronous), immediately following action potentials (asynchronous), or as stochastic events in the absence of action potentials (spontaneous). Synaptotagmin-1, -2, and -9 are vesicleassociated Ca",

author = "A.J.A. Groffen and S. Martens and {Diez Arazola}, R. and L.N. Cornelisse and N. Lozovaya and {de Jong}, A.P.H. and N.A. Goriounova and R.L. Habets and Y. Takai and J.G. Borst and N. Brose and H.T. McMahon and M. Verhage",

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doi = "10.1126/science.1183765",

language = "English",

volume = "327",

pages = "1614--1618",

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TY - JOUR

T1 - Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter release

AU - Groffen, A.J.A.

AU - Martens, S.

AU - Diez Arazola, R.

AU - Cornelisse, L.N.

AU - Lozovaya, N.

AU - de Jong, A.P.H.

AU - Goriounova, N.A.

AU - Habets, R.L.

AU - Takai, Y.

AU - Borst, J.G.

AU - Brose, N.

AU - McMahon, H.T.

AU - Verhage, M.

PY - 2010

Y1 - 2010

N2 - Synaptic vesicle fusion in brain synapses occurs in phases that are either tightly coupled to action potentials (synchronous), immediately following action potentials (asynchronous), or as stochastic events in the absence of action potentials (spontaneous). Synaptotagmin-1, -2, and -9 are vesicleassociated Ca

AB - Synaptic vesicle fusion in brain synapses occurs in phases that are either tightly coupled to action potentials (synchronous), immediately following action potentials (asynchronous), or as stochastic events in the absence of action potentials (spontaneous). Synaptotagmin-1, -2, and -9 are vesicleassociated Ca

U2 - 10.1126/science.1183765

DO - 10.1126/science.1183765

M3 - Article

SN - 0036-8075

VL - 327

SP - 1614

EP - 1618

JO - Science

JF - Science

IS - 5973

ER -

Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter release

Abstract

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