Doc2b Is a Key Effector of Insulin Secretion and Skeletal Muscle Insulin Sensitivity

L. Ramalingam, E. Oh, S.M. Yoder, J.T. Brozinick, M.A. Kalwat, A.J.A. Groffen, M. Verhage, D.C. Thurmond

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Exocytosis of intracellular vesicles, such as insulin granules, is carried out by soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) and Sec1/Munc18 (SM) proteins. An additional regulatory protein, Doc2b (double C2 domain), has recently been implicated in exocytosis from clonal β-cells and 3T3-L1 adipocytes. Here, we investigated the role of Doc2b in insulin secretion, insulin sensitivity, and the maintenance of whole-body glucose homeostasis. Doc2b heterozygous (Doc2b
Original languageEnglish
Pages (from-to)2424-2432
JournalDiabetes
Volume61
Issue number10
DOIs
Publication statusPublished - 2012

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