Domain swapping in the human histamine H1 receptor

R.A. Bakker, G. Dees, J.J. Carrillo, R.G. Booth, J.F. Lopez-Gimenez, G. Milligan, P.G. Strange, R. Leurs

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

G-protein-coupled receptors (GPCRs) represent the largest Family of receptors involved in transmembrane signaling. Although these receptors were generally believed to be monomeric entities, accumulating evidence supports the presence of GPCRs in multimeric forms. Here, using immunoprecipitation as well as time-resolved fluorescence resonance energy transfer to assess protein-protein interactions in living cells, we unambiguously demonstrate the occurrence of dimerization of the human histamine H
Original languageEnglish
Pages (from-to)131-8
JournalThe Journal of Pharmacology and Experimental Therapeutics
Volume311
Issue number1
DOIs
Publication statusPublished - 2004

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