Domain swapping in the human histamine H1 receptor

R.A. Bakker, G. Dees, J.J. Carrillo, R.G. Booth, J.F. Lopez-Gimenez, G. Milligan, P.G. Strange, R. Leurs

    Research output: Contribution to JournalArticleAcademicpeer-review

    Abstract

    G-protein-coupled receptors (GPCRs) represent the largest Family of receptors involved in transmembrane signaling. Although these receptors were generally believed to be monomeric entities, accumulating evidence supports the presence of GPCRs in multimeric forms. Here, using immunoprecipitation as well as time-resolved fluorescence resonance energy transfer to assess protein-protein interactions in living cells, we unambiguously demonstrate the occurrence of dimerization of the human histamine H
    Original languageEnglish
    Pages (from-to)131-8
    JournalThe Journal of Pharmacology and Experimental Therapeutics
    Volume311
    Issue number1
    DOIs
    Publication statusPublished - 2004

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