Domain swapping in the human histamine H1 receptor

R.A. Bakker; G. Dees; J.J. Carrillo; R.G. Booth; J.F. Lopez-Gimenez; G. Milligan; P.G. Strange; R. Leurs

doi:10.1124/jpet.104.067041

Domain swapping in the human histamine H1 receptor

R.A. Bakker, G. Dees, J.J. Carrillo, R.G. Booth, J.F. Lopez-Gimenez, G. Milligan, P.G. Strange, R. Leurs

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

G-protein-coupled receptors (GPCRs) represent the largest Family of receptors involved in transmembrane signaling. Although these receptors were generally believed to be monomeric entities, accumulating evidence supports the presence of GPCRs in multimeric forms. Here, using immunoprecipitation as well as time-resolved fluorescence resonance energy transfer to assess protein-protein interactions in living cells, we unambiguously demonstrate the occurrence of dimerization of the human histamine H

Original language	English
Pages (from-to)	131-8
Journal	The Journal of Pharmacology and Experimental Therapeutics
Volume	311
Issue number	1
DOIs	https://doi.org/10.1124/jpet.104.067041
Publication status	Published - 2004

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10.1124/jpet.104.067041

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AU - Bakker, R.A.

AU - Dees, G.

AU - Carrillo, J.J.

AU - Booth, R.G.

AU - Lopez-Gimenez, J.F.

AU - Milligan, G.

AU - Strange, P.G.

AU - Leurs, R.

PY - 2004

Y1 - 2004

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AB - G-protein-coupled receptors (GPCRs) represent the largest Family of receptors involved in transmembrane signaling. Although these receptors were generally believed to be monomeric entities, accumulating evidence supports the presence of GPCRs in multimeric forms. Here, using immunoprecipitation as well as time-resolved fluorescence resonance energy transfer to assess protein-protein interactions in living cells, we unambiguously demonstrate the occurrence of dimerization of the human histamine H

U2 - 10.1124/jpet.104.067041

DO - 10.1124/jpet.104.067041

M3 - Article

SN - 0022-3565

VL - 311

SP - 131

EP - 138

JO - The Journal of Pharmacology and Experimental Therapeutics

JF - The Journal of Pharmacology and Experimental Therapeutics

IS - 1

ER -

Domain swapping in the human histamine H1 receptor

Abstract

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