Donor InSight: characteristics and representativeness of a Dutch cohort study on blood and plasma donors

Tiffany C Timmer; Rosa de Groot; Karin Habets; Eva-Maria Merz; Femmeke J Prinsze; Femke Atsma; Wim L A M de Kort; Katja van den Hurk

doi:10.1111/vox.12731

Donor InSight: characteristics and representativeness of a Dutch cohort study on blood and plasma donors

Tiffany C Timmer, Rosa de Groot, Karin Habets, Eva-Maria Merz, Femmeke J Prinsze, Femke Atsma, Wim L A M de Kort, Katja van den Hurk

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

BACKGROUND AND OBJECTIVES: More insight into donor health and behaviour may contribute to more efficient and focused strategies regarding donor care and management. Donor InSight (DIS) is a Dutch cohort study of blood and plasma donors. We aimed to outline the objectives and methods of DIS, describe the cohort, and compare it to the active Dutch donor population.

MATERIALS AND METHODS: In 2007-2009 (DIS-I, n = 31 338) and 2012-2013 (DIS-II, 34 826, of whom 22 132 also participated in DIS-I) questionnaire data on demographics, donation, lifestyle, family composition, health and disease were collected. A second follow-up (DIS-III, n = 3046), including donors with differing haemoglobin trajectories, was completed in 2015-2016. DIS-III includes data on genetic determinants, iron and red cell indices. Representativeness of the DIS-I sample for the entire Dutch donor population was assessed by comparing characteristics of both.

RESULTS: Donor InSight was initially set up because of a need for more detailed information and evidence as a basis for decision-making in blood banks. DIS-I sample is comparable to the total Dutch donor population in terms of age, body mass index, haemoglobin level, blood pressure, blood type and donation behaviour.

CONCLUSION: Donor InSight is a cohort study representative of the Dutch donor population. It provides evidence to support evidence-based decision making.

Original language	English
Pages (from-to)	117-128
Number of pages	12
Journal	Vox Sanguinis
Volume	114
Issue number	2
Early online date	27 Dec 2018
DOIs	https://doi.org/10.1111/vox.12731
Publication status	Published - 2019

Funding

Donor InSight was initiated by the Unit Donor Services, Division Blood Bank and the Department of Donor Studies, Division Research, of Sanquin and was funded by the peer reviewed grant from Sanquin's Fund for Product and Process Development Cellular Products (PPOC 14-028; PPOC-14-DS-01). We are grateful to all participants for their contribution to the study and for their voluntary donations of blood (components) for patients in need. We are thankful to all researchers, research assistants and blood bank personnel for their ongoing commitment to DIS and the donor database.

Funders	Funder number
Division Blood Bank
Sanquin's Fund for Product and Process Development Cellular Products	PPOC 14-028, PPOC-14-DS-01
Unit Donor Services

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Donor InSight: characteristics and representativeness of a Dutch cohort study on blood and plasma donors",

abstract = "BACKGROUND AND OBJECTIVES: More insight into donor health and behaviour may contribute to more efficient and focused strategies regarding donor care and management. Donor InSight (DIS) is a Dutch cohort study of blood and plasma donors. We aimed to outline the objectives and methods of DIS, describe the cohort, and compare it to the active Dutch donor population.MATERIALS AND METHODS: In 2007-2009 (DIS-I, n = 31 338) and 2012-2013 (DIS-II, 34 826, of whom 22 132 also participated in DIS-I) questionnaire data on demographics, donation, lifestyle, family composition, health and disease were collected. A second follow-up (DIS-III, n = 3046), including donors with differing haemoglobin trajectories, was completed in 2015-2016. DIS-III includes data on genetic determinants, iron and red cell indices. Representativeness of the DIS-I sample for the entire Dutch donor population was assessed by comparing characteristics of both.RESULTS: Donor InSight was initially set up because of a need for more detailed information and evidence as a basis for decision-making in blood banks. DIS-I sample is comparable to the total Dutch donor population in terms of age, body mass index, haemoglobin level, blood pressure, blood type and donation behaviour.CONCLUSION: Donor InSight is a cohort study representative of the Dutch donor population. It provides evidence to support evidence-based decision making.",

author = "Timmer, {Tiffany C} and {de Groot}, Rosa and Karin Habets and Eva-Maria Merz and Prinsze, {Femmeke J} and Femke Atsma and {de Kort}, {Wim L A M} and {van den Hurk}, Katja",

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AU - Timmer, Tiffany C

AU - de Groot, Rosa

AU - Habets, Karin

AU - Merz, Eva-Maria

AU - Prinsze, Femmeke J

AU - Atsma, Femke

AU - de Kort, Wim L A M

AU - van den Hurk, Katja

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N2 - BACKGROUND AND OBJECTIVES: More insight into donor health and behaviour may contribute to more efficient and focused strategies regarding donor care and management. Donor InSight (DIS) is a Dutch cohort study of blood and plasma donors. We aimed to outline the objectives and methods of DIS, describe the cohort, and compare it to the active Dutch donor population.MATERIALS AND METHODS: In 2007-2009 (DIS-I, n = 31 338) and 2012-2013 (DIS-II, 34 826, of whom 22 132 also participated in DIS-I) questionnaire data on demographics, donation, lifestyle, family composition, health and disease were collected. A second follow-up (DIS-III, n = 3046), including donors with differing haemoglobin trajectories, was completed in 2015-2016. DIS-III includes data on genetic determinants, iron and red cell indices. Representativeness of the DIS-I sample for the entire Dutch donor population was assessed by comparing characteristics of both.RESULTS: Donor InSight was initially set up because of a need for more detailed information and evidence as a basis for decision-making in blood banks. DIS-I sample is comparable to the total Dutch donor population in terms of age, body mass index, haemoglobin level, blood pressure, blood type and donation behaviour.CONCLUSION: Donor InSight is a cohort study representative of the Dutch donor population. It provides evidence to support evidence-based decision making.

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Donor InSight: characteristics and representativeness of a Dutch cohort study on blood and plasma donors

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