Dopamine Receptor D-1/D-5 Gene Expression in the Medial Prefrontal Cortex Predicts Impulsive Choice in Rats

M. Loos; T. Pattij; M.C.W. Janssen; D.S. Counotte; A.N.M. Schoffelmeer; A.B. Smit; S. Spijker; M.M. van Gaalen

doi:10.1093/cercor/bhp167

Dopamine Receptor D-1/D-5 Gene Expression in the Medial Prefrontal Cortex Predicts Impulsive Choice in Rats

M. Loos
, T. Pattij
, M.C.W. Janssen
, D.S. Counotte
, A.N.M. Schoffelmeer
, A.B. Smit
, S. Spijker
, M.M. van Gaalen

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

A neuropsychological hallmark of attention deficit/hyperactivity disorder (ADHD) is the reduced ability to tolerate delay of reinforcement, leading to impulsive choice. Genetic association studies have implicated several genes involved in dopaminergic neurotransmission in ADHD. In this study, we investigated whether differences in the expression level of these dopamine-related genes of rats predict the individual level of impulsive choice. Among all frontostriatal brain regions tested, only in the medial prefrontal cortex (mPFC), we observed significant positive correlations between impulsive choice and transcript levels of the dopamine receptor D1, the dopamine receptor D5 and calcyon. Local mPFC infusions of the D

Original language	English
Pages (from-to)	1064-1070
Journal	Cerebral Cortex
Volume	20
Issue number	5
DOIs	https://doi.org/10.1093/cercor/bhp167
Publication status	Published - 2010

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title = "Dopamine Receptor D-1/D-5 Gene Expression in the Medial Prefrontal Cortex Predicts Impulsive Choice in Rats",

abstract = "A neuropsychological hallmark of attention deficit/hyperactivity disorder (ADHD) is the reduced ability to tolerate delay of reinforcement, leading to impulsive choice. Genetic association studies have implicated several genes involved in dopaminergic neurotransmission in ADHD. In this study, we investigated whether differences in the expression level of these dopamine-related genes of rats predict the individual level of impulsive choice. Among all frontostriatal brain regions tested, only in the medial prefrontal cortex (mPFC), we observed significant positive correlations between impulsive choice and transcript levels of the dopamine receptor D1, the dopamine receptor D5 and calcyon. Local mPFC infusions of the D",

author = "M. Loos and T. Pattij and M.C.W. Janssen and D.S. Counotte and A.N.M. Schoffelmeer and A.B. Smit and S. Spijker and \{van Gaalen\}, M.M.",

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doi = "10.1093/cercor/bhp167",

language = "English",

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AU - Loos, M.

AU - Pattij, T.

AU - Janssen, M.C.W.

AU - Counotte, D.S.

AU - Schoffelmeer, A.N.M.

AU - Smit, A.B.

AU - Spijker, S.

AU - van Gaalen, M.M.

PY - 2010

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N2 - A neuropsychological hallmark of attention deficit/hyperactivity disorder (ADHD) is the reduced ability to tolerate delay of reinforcement, leading to impulsive choice. Genetic association studies have implicated several genes involved in dopaminergic neurotransmission in ADHD. In this study, we investigated whether differences in the expression level of these dopamine-related genes of rats predict the individual level of impulsive choice. Among all frontostriatal brain regions tested, only in the medial prefrontal cortex (mPFC), we observed significant positive correlations between impulsive choice and transcript levels of the dopamine receptor D1, the dopamine receptor D5 and calcyon. Local mPFC infusions of the D

AB - A neuropsychological hallmark of attention deficit/hyperactivity disorder (ADHD) is the reduced ability to tolerate delay of reinforcement, leading to impulsive choice. Genetic association studies have implicated several genes involved in dopaminergic neurotransmission in ADHD. In this study, we investigated whether differences in the expression level of these dopamine-related genes of rats predict the individual level of impulsive choice. Among all frontostriatal brain regions tested, only in the medial prefrontal cortex (mPFC), we observed significant positive correlations between impulsive choice and transcript levels of the dopamine receptor D1, the dopamine receptor D5 and calcyon. Local mPFC infusions of the D

U2 - 10.1093/cercor/bhp167

DO - 10.1093/cercor/bhp167

M3 - Article

SN - 1047-3211

VL - 20

SP - 1064

EP - 1070

JO - Cerebral Cortex

JF - Cerebral Cortex

IS - 5

ER -

Dopamine Receptor D-1/D-5 Gene Expression in the Medial Prefrontal Cortex Predicts Impulsive Choice in Rats

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