Drug target identification through systems biology.

J.R. Haanstra; B.M. Bakker

doi:10.1016/j.ddtec.2015.06.002

Drug target identification through systems biology.

J.R. Haanstra, B.M. Bakker

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Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

To rationalise drug target selection, we should understand the role of putative targets in biological pathways quantitatively. We review here how experimental and computational network-based approaches can aid more rational drug target selection and illustrate this with results obtained for microbes and for cancer. Comparison of the drug response of biochemical networks in target cells and (healthy) host cells can reveal network-selective targets.

Original language	English
Pages (from-to)	17-22
Journal	Drug Discovery Today: Technologies
Volume	15
DOIs	https://doi.org/10.1016/j.ddtec.2015.06.002
Publication status	Published - 2015

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10.1016/j.ddtec.2015.06.002

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title = "Drug target identification through systems biology.",

abstract = "To rationalise drug target selection, we should understand the role of putative targets in biological pathways quantitatively. We review here how experimental and computational network-based approaches can aid more rational drug target selection and illustrate this with results obtained for microbes and for cancer. Comparison of the drug response of biochemical networks in target cells and (healthy) host cells can reveal network-selective targets.",

author = "J.R. Haanstra and B.M. Bakker",

year = "2015",

doi = "10.1016/j.ddtec.2015.06.002",

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AU - Haanstra, J.R.

AU - Bakker, B.M.

PY - 2015

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AB - To rationalise drug target selection, we should understand the role of putative targets in biological pathways quantitatively. We review here how experimental and computational network-based approaches can aid more rational drug target selection and illustrate this with results obtained for microbes and for cancer. Comparison of the drug response of biochemical networks in target cells and (healthy) host cells can reveal network-selective targets.

U2 - 10.1016/j.ddtec.2015.06.002

DO - 10.1016/j.ddtec.2015.06.002

M3 - Article

SN - 1740-6749

VL - 15

SP - 17

EP - 22

JO - Drug Discovery Today: Technologies

JF - Drug Discovery Today: Technologies

ER -

Drug target identification through systems biology.

Abstract

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