Drug target identification through systems biology.

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

To rationalise drug target selection, we should understand the role of putative targets in biological pathways quantitatively. We review here how experimental and computational network-based approaches can aid more rational drug target selection and illustrate this with results obtained for microbes and for cancer. Comparison of the drug response of biochemical networks in target cells and (healthy) host cells can reveal network-selective targets.
Original languageEnglish
Pages (from-to)17-22
JournalDrug Discovery Today: Technologies
Volume15
DOIs
Publication statusPublished - 2015

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title = "Drug target identification through systems biology.",
abstract = "To rationalise drug target selection, we should understand the role of putative targets in biological pathways quantitatively. We review here how experimental and computational network-based approaches can aid more rational drug target selection and illustrate this with results obtained for microbes and for cancer. Comparison of the drug response of biochemical networks in target cells and (healthy) host cells can reveal network-selective targets.",
author = "J.R. Haanstra and B.M. Bakker",
year = "2015",
doi = "10.1016/j.ddtec.2015.06.002",
language = "English",
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pages = "17--22",
journal = "Drug Discovery Today: Technologies",
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publisher = "Elsevier Limited",

}

Drug target identification through systems biology. / Haanstra, J.R.; Bakker, B.M.

In: Drug Discovery Today: Technologies, Vol. 15, 2015, p. 17-22.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

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AU - Haanstra, J.R.

AU - Bakker, B.M.

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AB - To rationalise drug target selection, we should understand the role of putative targets in biological pathways quantitatively. We review here how experimental and computational network-based approaches can aid more rational drug target selection and illustrate this with results obtained for microbes and for cancer. Comparison of the drug response of biochemical networks in target cells and (healthy) host cells can reveal network-selective targets.

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DO - 10.1016/j.ddtec.2015.06.002

M3 - Article

VL - 15

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JO - Drug Discovery Today: Technologies

JF - Drug Discovery Today: Technologies

SN - 1740-6749

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