Dynamic modulation of decision biases by brainstem arousal systems

Jan Willem de Gee*, Olympia Colizoli, Niels A. Kloosterman, Tomas Knapen, Sander Nieuwenhuis, Tobias H. Donner

*Corresponding author for this work

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Decision-makers often arrive at different choices when faced with repeated presentations of the same evidence. Variability of behavior is commonly attributed to noise in the brain’s decision-making machinery. We hypothesized that phasic responses of brainstem arousal systems are a significant source of this variability. We tracked pupil responses (a proxy of phasic arousal) during sensory-motor decisions in humans, across different sensory modalities and task protocols. Large pupil responses generally predicted a reduction in decision bias. Using fMRI, we showed that the pupil-linked bias reduction was (i) accompanied by a modulation of choice-encoding pattern signals in parietal and prefrontal cortex and (ii) predicted by phasic, pupil-linked responses of a number of neuromodulatory brainstem centers involved in the control of cortical arousal state, including the noradrenergic locus coeruleus. We conclude that phasic arousal suppresses decision bias on a trial-by-trial basis, thus accounting for a significant component of the variability of choice behavior.

Original languageEnglish
Article numbere23232
JournaleLife
Volume6
DOIs
Publication statusPublished - 11 Apr 2017

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