Earlier Detection of Glaucoma Progression Using High-Density 3-Dimensional Spectral-Domain OCT Optic Nerve Volume Scans

Kitiya Ratanawongphaibul; Edem Tsikata; Michele Zemplenyi; Hang Lee; Milica A. Margeta; Courtney L. Ondeck; Janice Kim; Billy X. Pan; Paul Petrakos; Anne L. Coleman; Fei Yu; Johannes F. de Boer; Teresa C. Chen

doi:10.1016/j.ogla.2021.03.010

Earlier Detection of Glaucoma Progression Using High-Density 3-Dimensional Spectral-Domain OCT Optic Nerve Volume Scans

Kitiya Ratanawongphaibul, Edem Tsikata, Michele Zemplenyi, Hang Lee, Milica A. Margeta, Courtney L. Ondeck, Janice Kim, Billy X. Pan, Paul Petrakos, Anne L. Coleman, Fei Yu, Johannes F. de Boer, Teresa C. Chen^*

^*Corresponding author for this work

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Purpose: To compare onset times of glaucoma progression among different glaucoma tests: disc photography (DP), visual field (VF) testing, 2-dimensional (2D) retinal nerve fiber layer (RNFL) thickness, and 3-dimensional (3D) spectral-domain (SD) OCT neuroretinal rim measurements. Design: Prospective, longitudinal cohort study. Participants: One hundred twenty-four eyes of 124 patients with open-angle glaucoma. Methods: Over a 5-year period, 124 patients with open-angle glaucoma underwent yearly DP, VF testing, SD OCT RNFL thickness scans, and optic nerve volume scans (Spectralis; Heidelberg Engineering), all performed on the same day. From high-density optic nerve volume scans, custom-built software calculated the minimum distance band (MDB) thickness, a 3D neuroretinal rim parameter. Patients were classified as glaucoma progressors or nonglaucoma progressors using event-based analysis. Progression by DP and VF testing occurred when 3 masked glaucoma specialists unanimously concurred. Progression by RNFL and MDB thickness occurred if change of more than test–retest variability was observed. Kaplan-Meier curves were constructed to analyze time-to-progression data. Kappa Coefficients were used to measure agreement of progressing eyes among methods. Main Outcome Measures: Time to glaucoma progression among all 4 methods. Results: Global MDB thickness detected glaucoma progression in the highest percentage of eyes (52.4%) compared with DP (16.1%; P < 0.001) and global RNFL thickness (15.3%; P < 0.001). Global MDB thickness detected glaucoma progression earlier than either DP (23 months vs. 44 months; P < 0.001) or global RNFL thickness (23 months vs. 33 months; P < 0.001). Among MDB progressing eyes, 46.2% were confirmed simultaneously or later by other conventional methods. Agreement of glaucoma-progressing eyes for all 4 methods in paired fashion were slight to fair (κ = 0.095–0.300). Conclusions: High-density 3D SD OCT neuroretinal rim measurements detected glaucoma progression approximately 1 to 2 years earlier compared with current clinically available structural tests (i.e., DP and 2D RNFL thickness measurements).

Original language	English
Pages (from-to)	604-616
Number of pages	13
Journal	Ophthalmology Glaucoma
Volume	4
Issue number	6
Early online date	25 Mar 2021
DOIs	https://doi.org/10.1016/j.ogla.2021.03.010
Publication status	Published - Nov 2021

Bibliographical note

Funding Information:
Supported by the National Institutes of Health, Bethesda, Maryland (grant no.: UL1 RR 025758 [Harvard Catalyst Grant to T.C.C.]); Massachusetts Lions Eye Research Fund, New Bedford and Boston, Massachusetts (T.C.C.); American Glaucoma Society, San Francisco, California (Mid-Career Award [T.C.C.]); Fidelity Charitable Fund of Harvard University, Boston, Massachusetts (T.C.C.); the Department of Defense (Small Business Innovation Research award no.: DHP15-016 [T.C.C.]). The funding sources had no role in the study design or conduct of this research. J.F.dB.: Consultant ? UK-based law firm (expert testimony); Financial support ? TNO, Heidelberg Engineering, Dutch Science Foundation (NWO); Patent and Royalties ? Mass General Hospital, VU University. Obtained funding: Chen

Publisher Copyright:
© 2021 American Academy of Ophthalmology

Keywords

Glaucoma progression
Neuroretinal rim
Optic nerve
Spectral-domain OCT
Volume scans

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Ratanawongphaibul, K., Tsikata, E., Zemplenyi, M., Lee, H., Margeta, M. A., Ondeck, C. L., Kim, J., Pan, B. X., Petrakos, P., Coleman, A. L., Yu, F., de Boer, J. F., & Chen, T. C. (2021). Earlier Detection of Glaucoma Progression Using High-Density 3-Dimensional Spectral-Domain OCT Optic Nerve Volume Scans. Ophthalmology Glaucoma, 4(6), 604-616. https://doi.org/10.1016/j.ogla.2021.03.010

@article{810f9fa511c54a198932a37444075ea9,

title = "Earlier Detection of Glaucoma Progression Using High-Density 3-Dimensional Spectral-Domain OCT Optic Nerve Volume Scans",

abstract = "Purpose: To compare onset times of glaucoma progression among different glaucoma tests: disc photography (DP), visual field (VF) testing, 2-dimensional (2D) retinal nerve fiber layer (RNFL) thickness, and 3-dimensional (3D) spectral-domain (SD) OCT neuroretinal rim measurements. Design: Prospective, longitudinal cohort study. Participants: One hundred twenty-four eyes of 124 patients with open-angle glaucoma. Methods: Over a 5-year period, 124 patients with open-angle glaucoma underwent yearly DP, VF testing, SD OCT RNFL thickness scans, and optic nerve volume scans (Spectralis; Heidelberg Engineering), all performed on the same day. From high-density optic nerve volume scans, custom-built software calculated the minimum distance band (MDB) thickness, a 3D neuroretinal rim parameter. Patients were classified as glaucoma progressors or nonglaucoma progressors using event-based analysis. Progression by DP and VF testing occurred when 3 masked glaucoma specialists unanimously concurred. Progression by RNFL and MDB thickness occurred if change of more than test–retest variability was observed. Kaplan-Meier curves were constructed to analyze time-to-progression data. Kappa Coefficients were used to measure agreement of progressing eyes among methods. Main Outcome Measures: Time to glaucoma progression among all 4 methods. Results: Global MDB thickness detected glaucoma progression in the highest percentage of eyes (52.4%) compared with DP (16.1%; P < 0.001) and global RNFL thickness (15.3%; P < 0.001). Global MDB thickness detected glaucoma progression earlier than either DP (23 months vs. 44 months; P < 0.001) or global RNFL thickness (23 months vs. 33 months; P < 0.001). Among MDB progressing eyes, 46.2% were confirmed simultaneously or later by other conventional methods. Agreement of glaucoma-progressing eyes for all 4 methods in paired fashion were slight to fair (κ = 0.095–0.300). Conclusions: High-density 3D SD OCT neuroretinal rim measurements detected glaucoma progression approximately 1 to 2 years earlier compared with current clinically available structural tests (i.e., DP and 2D RNFL thickness measurements).",

keywords = "Glaucoma progression, Neuroretinal rim, Optic nerve, Spectral-domain OCT, Volume scans",

author = "Kitiya Ratanawongphaibul and Edem Tsikata and Michele Zemplenyi and Hang Lee and Margeta, {Milica A.} and Ondeck, {Courtney L.} and Janice Kim and Pan, {Billy X.} and Paul Petrakos and Coleman, {Anne L.} and Fei Yu and {de Boer}, {Johannes F.} and Chen, {Teresa C.}",

note = "Funding Information: Supported by the National Institutes of Health, Bethesda, Maryland (grant no.: UL1 RR 025758 [Harvard Catalyst Grant to T.C.C.]); Massachusetts Lions Eye Research Fund, New Bedford and Boston, Massachusetts (T.C.C.); American Glaucoma Society, San Francisco, California (Mid-Career Award [T.C.C.]); Fidelity Charitable Fund of Harvard University, Boston, Massachusetts (T.C.C.); the Department of Defense (Small Business Innovation Research award no.: DHP15-016 [T.C.C.]). The funding sources had no role in the study design or conduct of this research. J.F.dB.: Consultant ? UK-based law firm (expert testimony); Financial support ? TNO, Heidelberg Engineering, Dutch Science Foundation (NWO); Patent and Royalties ? Mass General Hospital, VU University. Obtained funding: Chen Publisher Copyright: {\textcopyright} 2021 American Academy of Ophthalmology",

year = "2021",

month = nov,

doi = "10.1016/j.ogla.2021.03.010",

language = "English",

volume = "4",

pages = "604--616",

journal = "Ophthalmology Glaucoma",

issn = "2589-4234",

publisher = "Elsevier BV",

number = "6",

}

Ratanawongphaibul, K, Tsikata, E, Zemplenyi, M, Lee, H, Margeta, MA, Ondeck, CL, Kim, J, Pan, BX, Petrakos, P, Coleman, AL, Yu, F, de Boer, JF & Chen, TC 2021, 'Earlier Detection of Glaucoma Progression Using High-Density 3-Dimensional Spectral-Domain OCT Optic Nerve Volume Scans', Ophthalmology Glaucoma, vol. 4, no. 6, pp. 604-616. https://doi.org/10.1016/j.ogla.2021.03.010

TY - JOUR

T1 - Earlier Detection of Glaucoma Progression Using High-Density 3-Dimensional Spectral-Domain OCT Optic Nerve Volume Scans

AU - Ratanawongphaibul, Kitiya

AU - Tsikata, Edem

AU - Zemplenyi, Michele

AU - Lee, Hang

AU - Margeta, Milica A.

AU - Ondeck, Courtney L.

AU - Kim, Janice

AU - Pan, Billy X.

AU - Petrakos, Paul

AU - Coleman, Anne L.

AU - Yu, Fei

AU - de Boer, Johannes F.

AU - Chen, Teresa C.

N1 - Funding Information: Supported by the National Institutes of Health, Bethesda, Maryland (grant no.: UL1 RR 025758 [Harvard Catalyst Grant to T.C.C.]); Massachusetts Lions Eye Research Fund, New Bedford and Boston, Massachusetts (T.C.C.); American Glaucoma Society, San Francisco, California (Mid-Career Award [T.C.C.]); Fidelity Charitable Fund of Harvard University, Boston, Massachusetts (T.C.C.); the Department of Defense (Small Business Innovation Research award no.: DHP15-016 [T.C.C.]). The funding sources had no role in the study design or conduct of this research. J.F.dB.: Consultant ? UK-based law firm (expert testimony); Financial support ? TNO, Heidelberg Engineering, Dutch Science Foundation (NWO); Patent and Royalties ? Mass General Hospital, VU University. Obtained funding: Chen Publisher Copyright: © 2021 American Academy of Ophthalmology

PY - 2021/11

Y1 - 2021/11

N2 - Purpose: To compare onset times of glaucoma progression among different glaucoma tests: disc photography (DP), visual field (VF) testing, 2-dimensional (2D) retinal nerve fiber layer (RNFL) thickness, and 3-dimensional (3D) spectral-domain (SD) OCT neuroretinal rim measurements. Design: Prospective, longitudinal cohort study. Participants: One hundred twenty-four eyes of 124 patients with open-angle glaucoma. Methods: Over a 5-year period, 124 patients with open-angle glaucoma underwent yearly DP, VF testing, SD OCT RNFL thickness scans, and optic nerve volume scans (Spectralis; Heidelberg Engineering), all performed on the same day. From high-density optic nerve volume scans, custom-built software calculated the minimum distance band (MDB) thickness, a 3D neuroretinal rim parameter. Patients were classified as glaucoma progressors or nonglaucoma progressors using event-based analysis. Progression by DP and VF testing occurred when 3 masked glaucoma specialists unanimously concurred. Progression by RNFL and MDB thickness occurred if change of more than test–retest variability was observed. Kaplan-Meier curves were constructed to analyze time-to-progression data. Kappa Coefficients were used to measure agreement of progressing eyes among methods. Main Outcome Measures: Time to glaucoma progression among all 4 methods. Results: Global MDB thickness detected glaucoma progression in the highest percentage of eyes (52.4%) compared with DP (16.1%; P < 0.001) and global RNFL thickness (15.3%; P < 0.001). Global MDB thickness detected glaucoma progression earlier than either DP (23 months vs. 44 months; P < 0.001) or global RNFL thickness (23 months vs. 33 months; P < 0.001). Among MDB progressing eyes, 46.2% were confirmed simultaneously or later by other conventional methods. Agreement of glaucoma-progressing eyes for all 4 methods in paired fashion were slight to fair (κ = 0.095–0.300). Conclusions: High-density 3D SD OCT neuroretinal rim measurements detected glaucoma progression approximately 1 to 2 years earlier compared with current clinically available structural tests (i.e., DP and 2D RNFL thickness measurements).

AB - Purpose: To compare onset times of glaucoma progression among different glaucoma tests: disc photography (DP), visual field (VF) testing, 2-dimensional (2D) retinal nerve fiber layer (RNFL) thickness, and 3-dimensional (3D) spectral-domain (SD) OCT neuroretinal rim measurements. Design: Prospective, longitudinal cohort study. Participants: One hundred twenty-four eyes of 124 patients with open-angle glaucoma. Methods: Over a 5-year period, 124 patients with open-angle glaucoma underwent yearly DP, VF testing, SD OCT RNFL thickness scans, and optic nerve volume scans (Spectralis; Heidelberg Engineering), all performed on the same day. From high-density optic nerve volume scans, custom-built software calculated the minimum distance band (MDB) thickness, a 3D neuroretinal rim parameter. Patients were classified as glaucoma progressors or nonglaucoma progressors using event-based analysis. Progression by DP and VF testing occurred when 3 masked glaucoma specialists unanimously concurred. Progression by RNFL and MDB thickness occurred if change of more than test–retest variability was observed. Kaplan-Meier curves were constructed to analyze time-to-progression data. Kappa Coefficients were used to measure agreement of progressing eyes among methods. Main Outcome Measures: Time to glaucoma progression among all 4 methods. Results: Global MDB thickness detected glaucoma progression in the highest percentage of eyes (52.4%) compared with DP (16.1%; P < 0.001) and global RNFL thickness (15.3%; P < 0.001). Global MDB thickness detected glaucoma progression earlier than either DP (23 months vs. 44 months; P < 0.001) or global RNFL thickness (23 months vs. 33 months; P < 0.001). Among MDB progressing eyes, 46.2% were confirmed simultaneously or later by other conventional methods. Agreement of glaucoma-progressing eyes for all 4 methods in paired fashion were slight to fair (κ = 0.095–0.300). Conclusions: High-density 3D SD OCT neuroretinal rim measurements detected glaucoma progression approximately 1 to 2 years earlier compared with current clinically available structural tests (i.e., DP and 2D RNFL thickness measurements).

KW - Glaucoma progression

KW - Neuroretinal rim

KW - Optic nerve

KW - Spectral-domain OCT

KW - Volume scans

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JF - Ophthalmology Glaucoma

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Earlier Detection of Glaucoma Progression Using High-Density 3-Dimensional Spectral-Domain OCT Optic Nerve Volume Scans

Abstract

Bibliographical note

Keywords

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