TY - JOUR
T1 - Early Life Exposure to Antibiotics and Autism Spectrum Disorders: A Systematic Review
AU - Łukasik, J.
AU - Patro-Gołąb, B.
AU - Horvath, A.
AU - Baron, R.
AU - Szajewska, H.
AU - Besseling van der Vaart, I.
AU - Gieruszczak-Białek, D.
AU - Kołodziej, M.
AU - Pieścik-Lech, M.
AU - Seidell, J.
AU - Skórka, A.
AU - Taye, M.
AU - Ujcic, J.
AU - Verhoeff, A.
PY - 2019
Y1 - 2019
N2 - We systematically reviewed evidence from observational studies on the associations between autism spectrum disorders (ASD) and early-life antibiotic exposure. Eleven articles were included in the review. Prenatal antibiotic exposure was associated with a slightly increased risk of ASD in two cohort studies on overlapping populations and in one case–control study; in three other case–control studies, no significant association was found. One cohort study found a slightly reduced risk of ASD after postnatal antibiotic exposure, while two other cohort studies on overlapping populations and three case–control studies reported an increased risk. Meta-analysis of the eligible studies showed no significant associations. Current data are conflicting and do not conclusively support the hypothesis that early-life antibiotic exposure is associated with subsequent ASD development.
AB - We systematically reviewed evidence from observational studies on the associations between autism spectrum disorders (ASD) and early-life antibiotic exposure. Eleven articles were included in the review. Prenatal antibiotic exposure was associated with a slightly increased risk of ASD in two cohort studies on overlapping populations and in one case–control study; in three other case–control studies, no significant association was found. One cohort study found a slightly reduced risk of ASD after postnatal antibiotic exposure, while two other cohort studies on overlapping populations and three case–control studies reported an increased risk. Meta-analysis of the eligible studies showed no significant associations. Current data are conflicting and do not conclusively support the hypothesis that early-life antibiotic exposure is associated with subsequent ASD development.
UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-85067274317&partnerID=MN8TOARS
U2 - 10.1007/s10803-019-04093-y
DO - 10.1007/s10803-019-04093-y
M3 - Article
SN - 0162-3257
VL - 49
SP - 3866
EP - 3876
JO - Journal of Autism and Developmental Disorders
JF - Journal of Autism and Developmental Disorders
IS - 9
ER -
