Early Life Exposure to Antibiotics and Autism Spectrum Disorders: A Systematic Review

J. Łukasik, B. Patro-Gołąb, A. Horvath, R. Baron, H. Szajewska, I. Besseling van der Vaart, D. Gieruszczak-Białek, M. Kołodziej, M. Pieścik-Lech, J. Seidell, A. Skórka, M. Taye, J. Ujcic, A. Verhoeff

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We systematically reviewed evidence from observational studies on the associations between autism spectrum disorders (ASD) and early-life antibiotic exposure. Eleven articles were included in the review. Prenatal antibiotic exposure was associated with a slightly increased risk of ASD in two cohort studies on overlapping populations and in one case–control study; in three other case–control studies, no significant association was found. One cohort study found a slightly reduced risk of ASD after postnatal antibiotic exposure, while two other cohort studies on overlapping populations and three case–control studies reported an increased risk. Meta-analysis of the eligible studies showed no significant associations. Current data are conflicting and do not conclusively support the hypothesis that early-life antibiotic exposure is associated with subsequent ASD development.

Original languageUndefined/Unknown
Pages (from-to)3866-3876
JournalJournal of Autism and Developmental Disorders
Issue number9
Publication statusPublished - 2019

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