Early-stage [123I]beta-CIT SPECT and long-term clinical follow-up in patients with an initial diagnosis of Parkinson's disease

D. Stoffers; J. Booij; L. Bosscher; A. Winogrodzka; E.C.M.J. Wolters; H.W. Berendse

doi:10.1007/s00259-004-1733-4

Early-stage [123I]beta-CIT SPECT and long-term clinical follow-up in patients with an initial diagnosis of Parkinson's disease

D. Stoffers, J. Booij, L. Bosscher, A. Winogrodzka, E.C.M.J. Wolters, H.W. Berendse

Clinical Neuropsychology

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Abstract

Purpose: Previous studies using dopamine transporter single-photon emission computed tomography (SPECT) to try and distinguish between patients with idiopathic Parkinson's disease (IPD) and patients with atypical parkinsonian syndromes (APS) have mainly focussed on patients with an already established clinical diagnosis of several years' duration. Differences in the pattern of striatal involvement between IPD and APS have been found in only few studies. We hypothesized that distinguishing SPECT features might be most pronounced at an early disease stage, and the purpose of the present study was to investigate this hypothesis. Methods: The study included 72 patients with an initial clinical diagnosis of IPD, supported by decreased striatal [

Original language	English
Pages (from-to)	689-695
Number of pages	7
Journal	European Journal of Nuclear Medicine and Molecular Imaging
Volume	32
Issue number	6
DOIs	https://doi.org/10.1007/s00259-004-1733-4
Publication status	Published - 2005

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Stoffers European Journal of Nuclear Medicine and Molecular Imaging 32(6) 2005 uFinal published version, 155 KB

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AU - Stoffers, D.

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AU - Bosscher, L.

AU - Winogrodzka, A.

AU - Wolters, E.C.M.J.

AU - Berendse, H.W.

PY - 2005

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N2 - Purpose: Previous studies using dopamine transporter single-photon emission computed tomography (SPECT) to try and distinguish between patients with idiopathic Parkinson's disease (IPD) and patients with atypical parkinsonian syndromes (APS) have mainly focussed on patients with an already established clinical diagnosis of several years' duration. Differences in the pattern of striatal involvement between IPD and APS have been found in only few studies. We hypothesized that distinguishing SPECT features might be most pronounced at an early disease stage, and the purpose of the present study was to investigate this hypothesis. Methods: The study included 72 patients with an initial clinical diagnosis of IPD, supported by decreased striatal [

AB - Purpose: Previous studies using dopamine transporter single-photon emission computed tomography (SPECT) to try and distinguish between patients with idiopathic Parkinson's disease (IPD) and patients with atypical parkinsonian syndromes (APS) have mainly focussed on patients with an already established clinical diagnosis of several years' duration. Differences in the pattern of striatal involvement between IPD and APS have been found in only few studies. We hypothesized that distinguishing SPECT features might be most pronounced at an early disease stage, and the purpose of the present study was to investigate this hypothesis. Methods: The study included 72 patients with an initial clinical diagnosis of IPD, supported by decreased striatal [

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Early-stage [123I]beta-CIT SPECT and long-term clinical follow-up in patients with an initial diagnosis of Parkinson's disease

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