This special issue of Spatial Economic Analysis, on 'Modelling Regional Dynamics', contains an interesting set of novel contributions put together by guest co-editors Peter Mulder, Peter Nijkamp & Roger Stough, who have also summarized and commented on the papers below. The papers are as follows. First, Ugo Fratesi & Roberta Capello write about 'Modelling Regional Growth: An Advanced MASST Model'. Next we have the contribution by Emmanouil Tranos entitled 'The Causal Effect of the Internet Infrastructure on the Economic Development of European City Regions'. Then Marco Percoco considers 'Entrepreneurship, Social Capital and Institutions: Evidence from Italy'; and Megha Mukim asks the question, 'Does Agglomeration Boost Innovation? An Econometric Evaluation'. The final paper, by Aki Kangasharju, Christophe Tavera & Peter Nijkamp, is entitled 'Regional Growth and Unemployment: The Validity of Okun's Law for the Finnish Regions'.