EEG Resting State Functional Connectivity in Adult Dyslexics Using Phase Lag Index and Graph Analysis

Gorka Fraga González*, Dirk J.A. Smit, Melle J.W. van der Molen, Jurgen Tijms, Cornelis Jan Stam, Eco J.C. de Geus, Maurits W. van der Molen

*Corresponding author for this work

Research output: Contribution to JournalArticleAcademicpeer-review


Developmental dyslexia may involve deficits in functional connectivity across widespread brain networks that enable fluent reading. We investigated the large-scale organization of electroencephalography (EEG) functional networks at rest in 28 dyslexics and 36 typically reading adults. For each frequency band (delta, theta alpha and beta), we assessed functional connectivity strength with the phase lag index (PLI). Network topology was examined using minimum spanning tree (MST) graphs derived from the functional connectivity matrices. We found significant group differences in the alpha band (8–13 Hz). The graph analysis indicated more interconnected nodes, in dyslexics compared to typical readers. The graph metrics were significantly correlated with age in dyslexics but not in typical readers, which may indicate more heterogeneity in maturation of brain networks in dyslexics. The present findings support the involvement of alpha oscillations in higher cognition and the sensitivity of graph metrics to characterize functional networks in adult dyslexia. Finally, the current results extend our previous findings on children.

Original languageEnglish
Article number341
Pages (from-to)1-12
Number of pages12
JournalFrontiers in Human Neuroscience
Publication statusPublished - 30 Aug 2018


This project is part of the research program ‘‘Characterization of functional brain network organization in dyslexia and development’’ funded by the Amsterdam Brain and Mind Project, a UvA-VUA Amsterdam Academic Alliance Initiative (

FundersFunder number
UvA-VUA Amsterdam Academic Alliance Initiative


    • Dyslexia
    • Electroencephalography (EEG)
    • Functional connectivity
    • Graph theory
    • Minimum spanning tree
    • Network


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