Abstract
Objective: The present study aimed to establish the efficacy of sodium hypochlorite mouthwash (NaOCl-MW) compared with a control mouthwash on plaque and clinical parameters of periodontal disease. Methods: MEDLINE-PubMed, Embase and Cochrane-CENTRAL databases were searched for clinical trials on patients with gingivitis or periodontitis that assessed the effect of NaOCl-MW in comparison with a negative or positive control on plaque index (PI), gingival index (GI), and bleeding index (BI) scores and probing pocket depth (PPD). Data were extracted from the eligible studies. Results: Seven eligible papers were retrieved, which together represented six clinical trials. The studies showed considerable heterogeneity regarding methodological and clinical aspects that did not permit a meta-analysis. Two of the three studies in which NaOCl-MW was compared with a negative control showed that NaOCl-MW significantly reduced PI, GI and BI, and no effect was found on PPD. In three studies, NaOCl-MW was assessed using chlorhexidine mouthwash (CHX-MW) as a positive control; no difference was found for GI and BI. One of the three comparisons showed a statistically significant PI score favouring NaOCl-MW. One study measured PPD and found it to be significant in favour of NaOCl-MW. Conclusions: Studies with a negative control group provided very weak quality evidence for a very small beneficial effect of NaOCl-MW on PI, GI and BI scores. Studies with a positive control group provided very weak quality evidence that NaOCl-MW had a similar effect as CHX-MW on PI, GI and BI scores. The outcome for PPD was inconclusive.
| Original language | English |
|---|---|
| Pages (from-to) | 40-52 |
| Number of pages | 13 |
| Journal | International Journal of Dental Hygiene |
| Volume | 20 |
| Issue number | 1 |
| Early online date | 10 May 2021 |
| DOIs | |
| Publication status | Published - Feb 2022 |
Bibliographical note
Funding Information:This study was in part prepared as obligation of first author to fulfil the requirements of the ACTA master programme of Dentistry. Hussain declares no conflicts of interest. Van der Weijden, Slot and their research team at ACTA have previously received either external advisor fees, lecturer fees or research grants from dental care product manufacturers. Those manufacturers included GABA/Colgate, Dentaid, Lactona, Oral‐B/Procter & Gamble, Sara Lee, Sunstar Philips Unilever, GSK, Listerine and Waterpik. This research received no specific grant from any funding agency in the public, commercial, or not‐for‐profit sectors. For this study, no funding was accepted, except for support from the listed institution. The work for this paper was performed by the regular academic appointments of Slot and Van der Weijden at the Academic Centre for Dentistry Amsterdam (ACTA).
Publisher Copyright:
© 2021 The Authors. International Journal of Dental Hygiene published by John Wiley & Sons Ltd.
Funding
This study was in part prepared as obligation of first author to fulfil the requirements of the ACTA master programme of Dentistry. Hussain declares no conflicts of interest. Van der Weijden, Slot and their research team at ACTA have previously received either external advisor fees, lecturer fees or research grants from dental care product manufacturers. Those manufacturers included GABA/Colgate, Dentaid, Lactona, Oral‐B/Procter & Gamble, Sara Lee, Sunstar Philips Unilever, GSK, Listerine and Waterpik. This research received no specific grant from any funding agency in the public, commercial, or not‐for‐profit sectors. For this study, no funding was accepted, except for support from the listed institution. The work for this paper was performed by the regular academic appointments of Slot and Van der Weijden at the Academic Centre for Dentistry Amsterdam (ACTA).
| Funders | Funder number |
|---|---|
| Maimonides University | |
| Universidade Federal do Rio de Janeiro |
Keywords
- dental plaque
- mouthwashes
- periodontal health
- sodium hypochlorite
- systematic review
