Effect of daily vitamin B-12 and folic acid supplementation on fracture incidence in elderly individuals with an elevated plasma homocysteine concentration: B-PROOF, a randomized controlled trial

J.P. van Wijngaarden; K.M.A. Swart; A.W. Enneman; R.A.M. Dhonukshe-Rutten; S.C. van Dijk; A.C. van der Ham; E.M. Brouwer-Brolsma; N.L. van der Zwaluw; L. Sohl; J.B.J. van Meurs; M.C. Zillikens; N.M. van Schoor; N. van der Velde; J. Brug; A. G. Uitterlinden; P.T.A.M. Lips; L.C.P.G. de Groot

doi:10.3945/ajcn.114.090043

Effect of daily vitamin B-12 and folic acid supplementation on fracture incidence in elderly individuals with an elevated plasma homocysteine concentration: B-PROOF, a randomized controlled trial

J.P. van Wijngaarden
, K.M.A. Swart
, A.W. Enneman
, R.A.M. Dhonukshe-Rutten
, S.C. van Dijk
, A.C. van der Ham
, E.M. Brouwer-Brolsma
, N.L. van der Zwaluw
, L. Sohl
, J.B.J. van Meurs
, M.C. Zillikens
, N.M. van Schoor
, N. van der Velde
, J. Brug
, A. G. Uitterlinden
, P.T.A.M. Lips
, L.C.P.G. de Groot

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Background: Elevated plasma homocysteine concentrations are a risk factor for osteoporotic fractures. Lowering homocysteine with combined vitamin B-12 and folic acid supplementation may reduce fracture risk.

Original language	English
Pages (from-to)	1578-1586
Journal	The American Journal of Clinical Nutrition
Volume	100
Issue number	6
DOIs	https://doi.org/10.3945/ajcn.114.090043
Publication status	Published - 2014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.3945/ajcn.114.090043

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van Wijngaarden, J. P., Swart, K. M. A., Enneman, A. W., Dhonukshe-Rutten, R. A. M., van Dijk, S. C., van der Ham, A. C., Brouwer-Brolsma, E. M., van der Zwaluw, N. L., Sohl, L., van Meurs, J. B. J., Zillikens, M. C., van Schoor, N. M., van der Velde, N., Brug, J., Uitterlinden, A. G., Lips, P. T. A. M., & de Groot, L. C. P. G. (2014). Effect of daily vitamin B-12 and folic acid supplementation on fracture incidence in elderly individuals with an elevated plasma homocysteine concentration: B-PROOF, a randomized controlled trial. The American Journal of Clinical Nutrition, 100(6), 1578-1586. https://doi.org/10.3945/ajcn.114.090043

@article{8baf41d4a9ff497fb7638eaca0bc290c,

title = "Effect of daily vitamin B-12 and folic acid supplementation on fracture incidence in elderly individuals with an elevated plasma homocysteine concentration: B-PROOF, a randomized controlled trial",

abstract = "Background: Elevated plasma homocysteine concentrations are a risk factor for osteoporotic fractures. Lowering homocysteine with combined vitamin B-12 and folic acid supplementation may reduce fracture risk.",

author = "\{van Wijngaarden\}, J.P. and K.M.A. Swart and A.W. Enneman and R.A.M. Dhonukshe-Rutten and \{van Dijk\}, S.C. and \{van der Ham\}, A.C. and E.M. Brouwer-Brolsma and \{van der Zwaluw\}, N.L. and L. Sohl and \{van Meurs\}, J.B.J. and M.C. Zillikens and \{van Schoor\}, N.M. and \{van der Velde\}, N. and J. Brug and Uitterlinden, \{A. G.\} and P.T.A.M. Lips and \{de Groot\}, L.C.P.G.",

year = "2014",

doi = "10.3945/ajcn.114.090043",

language = "English",

volume = "100",

pages = "1578--1586",

journal = "The American Journal of Clinical Nutrition",

issn = "0002-9165",

publisher = "Elsevier B.V.",

number = "6",

}

van Wijngaarden, JP, Swart, KMA, Enneman, AW, Dhonukshe-Rutten, RAM, van Dijk, SC, van der Ham, AC, Brouwer-Brolsma, EM, van der Zwaluw, NL, Sohl, L, van Meurs, JBJ, Zillikens, MC, van Schoor, NM, van der Velde, N, Brug, J, Uitterlinden, AG, Lips, PTAM & de Groot, LCPG 2014, 'Effect of daily vitamin B-12 and folic acid supplementation on fracture incidence in elderly individuals with an elevated plasma homocysteine concentration: B-PROOF, a randomized controlled trial', The American Journal of Clinical Nutrition, vol. 100, no. 6, pp. 1578-1586. https://doi.org/10.3945/ajcn.114.090043

Effect of daily vitamin B-12 and folic acid supplementation on fracture incidence in elderly individuals with an elevated plasma homocysteine concentration: B-PROOF, a randomized controlled trial. / van Wijngaarden, J.P.; Swart, K.M.A.; Enneman, A.W. et al.
In: The American Journal of Clinical Nutrition, Vol. 100, No. 6, 2014, p. 1578-1586.

Research output: Contribution to Journal › Article › Academic › peer-review

TY - JOUR

T1 - Effect of daily vitamin B-12 and folic acid supplementation on fracture incidence in elderly individuals with an elevated plasma homocysteine concentration: B-PROOF, a randomized controlled trial

AU - van Wijngaarden, J.P.

AU - Swart, K.M.A.

AU - Enneman, A.W.

AU - Dhonukshe-Rutten, R.A.M.

AU - van Dijk, S.C.

AU - van der Ham, A.C.

AU - Brouwer-Brolsma, E.M.

AU - van der Zwaluw, N.L.

AU - Sohl, L.

AU - van Meurs, J.B.J.

AU - Zillikens, M.C.

AU - van Schoor, N.M.

AU - van der Velde, N.

AU - Brug, J.

AU - Uitterlinden, A. G.

AU - Lips, P.T.A.M.

AU - de Groot, L.C.P.G.

PY - 2014

Y1 - 2014

N2 - Background: Elevated plasma homocysteine concentrations are a risk factor for osteoporotic fractures. Lowering homocysteine with combined vitamin B-12 and folic acid supplementation may reduce fracture risk.

AB - Background: Elevated plasma homocysteine concentrations are a risk factor for osteoporotic fractures. Lowering homocysteine with combined vitamin B-12 and folic acid supplementation may reduce fracture risk.

U2 - 10.3945/ajcn.114.090043

DO - 10.3945/ajcn.114.090043

M3 - Article

SN - 0002-9165

VL - 100

SP - 1578

EP - 1586

JO - The American Journal of Clinical Nutrition

JF - The American Journal of Clinical Nutrition

IS - 6

ER -

van Wijngaarden JP, Swart KMA, Enneman AW, Dhonukshe-Rutten RAM, van Dijk SC, van der Ham AC et al. Effect of daily vitamin B-12 and folic acid supplementation on fracture incidence in elderly individuals with an elevated plasma homocysteine concentration: B-PROOF, a randomized controlled trial. The American Journal of Clinical Nutrition. 2014;100(6):1578-1586. doi: 10.3945/ajcn.114.090043

Effect of daily vitamin B-12 and folic acid supplementation on fracture incidence in elderly individuals with an elevated plasma homocysteine concentration: B-PROOF, a randomized controlled trial

Abstract

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