Effect of diet with or without exercise on abdominal fat in postmenopausal women - A randomised trial

Willemijn A. Van Gemert, Petra H. Peeters, Anne M. May, Adriaan J.H. Doornbos, Sjoerd G. Elias, Job Van Der Palen, Wouter Veldhuis, Maaike Stapper, Jantine A. Schuit, Evelyn M. Monninkhof

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Background: We assessed the effect of equivalent weight loss with or without exercise on (intra-) abdominal fat in postmenopausal women in the SHAPE-2 study. Methods: The SHAPE-2 study is a three-armed randomised controlled trial conducted in 2012-2013 in the Netherlands. Postmenopausal overweight women were randomized to a diet (n = 97), exercise plus diet (n = 98) or control group (n = 48). Both intervention groups aimed for equivalent weight loss (6-7%) following a calorie-restricted diet (diet group) or a partly supervised intensive exercise programme (4 h per week) combined with a small caloric restriction (exercise plus diet group). Outcomes after 16 weeks are amount and distribution of abdominal fat, measured by magnetic resonance imaging (MRI) with the use of the three-point IDEAL Dixon method. Results: The diet and exercise plus diet group lost 6.1 and 6.9% body weight, respectively. Compared to controls, subcutaneous and intra-abdominal fat reduced significantly with both diet (- 12.5% and - 12.0%) and exercise plus diet (- 16.0% and - 14.6%). Direct comparison between both interventions revealed that the reduction in subcutaneous fat was statistically significantly larger in the group that combined exercise with diet: an additional 10.6 cm 2 (95%CI -18.7; - 2.4) was lost compared to the diet-only group. Intra-abdominal fat loss was not significantly larger in the exercise plus diet group (- 3.8 cm 2 , 95%CI -9.0; 1.3). Conclusions: We conclude that weight loss of 6-7% with diet or with exercise plus diet reduced both subcutaneous and intra-abdominal fat. Only subcutaneous fat statistically significantly reduced to a larger extent when exercise is combined with a small caloric restriction. Trial register: NCT01511276 (clinicaltrials.gov), prospectively registered.

Original languageEnglish
Article number174
Pages (from-to)1-9
Number of pages9
JournalBMC Public Health
Volume19
DOIs
Publication statusPublished - 11 Feb 2019

Fingerprint

Abdominal Fat
Exercise
Diet
Intra-Abdominal Fat
Weight Loss
Caloric Restriction
Subcutaneous Fat
Netherlands

Keywords

  • Exercise
  • Intra-abdominal fat
  • Subcutaneous fat
  • Weight loss

Cite this

Van Gemert, W. A., Peeters, P. H., May, A. M., Doornbos, A. J. H., Elias, S. G., Van Der Palen, J., ... Monninkhof, E. M. (2019). Effect of diet with or without exercise on abdominal fat in postmenopausal women - A randomised trial. BMC Public Health, 19, 1-9. [174]. https://doi.org/10.1186/s12889-019-6510-1
Van Gemert, Willemijn A. ; Peeters, Petra H. ; May, Anne M. ; Doornbos, Adriaan J.H. ; Elias, Sjoerd G. ; Van Der Palen, Job ; Veldhuis, Wouter ; Stapper, Maaike ; Schuit, Jantine A. ; Monninkhof, Evelyn M. / Effect of diet with or without exercise on abdominal fat in postmenopausal women - A randomised trial. In: BMC Public Health. 2019 ; Vol. 19. pp. 1-9.
@article{0824005bc2b74920836e5a93b71908b2,
title = "Effect of diet with or without exercise on abdominal fat in postmenopausal women - A randomised trial",
abstract = "Background: We assessed the effect of equivalent weight loss with or without exercise on (intra-) abdominal fat in postmenopausal women in the SHAPE-2 study. Methods: The SHAPE-2 study is a three-armed randomised controlled trial conducted in 2012-2013 in the Netherlands. Postmenopausal overweight women were randomized to a diet (n = 97), exercise plus diet (n = 98) or control group (n = 48). Both intervention groups aimed for equivalent weight loss (6-7{\%}) following a calorie-restricted diet (diet group) or a partly supervised intensive exercise programme (4 h per week) combined with a small caloric restriction (exercise plus diet group). Outcomes after 16 weeks are amount and distribution of abdominal fat, measured by magnetic resonance imaging (MRI) with the use of the three-point IDEAL Dixon method. Results: The diet and exercise plus diet group lost 6.1 and 6.9{\%} body weight, respectively. Compared to controls, subcutaneous and intra-abdominal fat reduced significantly with both diet (- 12.5{\%} and - 12.0{\%}) and exercise plus diet (- 16.0{\%} and - 14.6{\%}). Direct comparison between both interventions revealed that the reduction in subcutaneous fat was statistically significantly larger in the group that combined exercise with diet: an additional 10.6 cm 2 (95{\%}CI -18.7; - 2.4) was lost compared to the diet-only group. Intra-abdominal fat loss was not significantly larger in the exercise plus diet group (- 3.8 cm 2 , 95{\%}CI -9.0; 1.3). Conclusions: We conclude that weight loss of 6-7{\%} with diet or with exercise plus diet reduced both subcutaneous and intra-abdominal fat. Only subcutaneous fat statistically significantly reduced to a larger extent when exercise is combined with a small caloric restriction. Trial register: NCT01511276 (clinicaltrials.gov), prospectively registered.",
keywords = "Exercise, Intra-abdominal fat, Subcutaneous fat, Weight loss",
author = "{Van Gemert}, {Willemijn A.} and Peeters, {Petra H.} and May, {Anne M.} and Doornbos, {Adriaan J.H.} and Elias, {Sjoerd G.} and {Van Der Palen}, Job and Wouter Veldhuis and Maaike Stapper and Schuit, {Jantine A.} and Monninkhof, {Evelyn M.}",
year = "2019",
month = "2",
day = "11",
doi = "10.1186/s12889-019-6510-1",
language = "English",
volume = "19",
pages = "1--9",
journal = "BMC Public Health",
issn = "1471-2458",
publisher = "BioMed Central",

}

Van Gemert, WA, Peeters, PH, May, AM, Doornbos, AJH, Elias, SG, Van Der Palen, J, Veldhuis, W, Stapper, M, Schuit, JA & Monninkhof, EM 2019, 'Effect of diet with or without exercise on abdominal fat in postmenopausal women - A randomised trial' BMC Public Health, vol. 19, 174, pp. 1-9. https://doi.org/10.1186/s12889-019-6510-1

Effect of diet with or without exercise on abdominal fat in postmenopausal women - A randomised trial. / Van Gemert, Willemijn A.; Peeters, Petra H.; May, Anne M.; Doornbos, Adriaan J.H.; Elias, Sjoerd G.; Van Der Palen, Job; Veldhuis, Wouter; Stapper, Maaike; Schuit, Jantine A.; Monninkhof, Evelyn M.

In: BMC Public Health, Vol. 19, 174, 11.02.2019, p. 1-9.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - Effect of diet with or without exercise on abdominal fat in postmenopausal women - A randomised trial

AU - Van Gemert, Willemijn A.

AU - Peeters, Petra H.

AU - May, Anne M.

AU - Doornbos, Adriaan J.H.

AU - Elias, Sjoerd G.

AU - Van Der Palen, Job

AU - Veldhuis, Wouter

AU - Stapper, Maaike

AU - Schuit, Jantine A.

AU - Monninkhof, Evelyn M.

PY - 2019/2/11

Y1 - 2019/2/11

N2 - Background: We assessed the effect of equivalent weight loss with or without exercise on (intra-) abdominal fat in postmenopausal women in the SHAPE-2 study. Methods: The SHAPE-2 study is a three-armed randomised controlled trial conducted in 2012-2013 in the Netherlands. Postmenopausal overweight women were randomized to a diet (n = 97), exercise plus diet (n = 98) or control group (n = 48). Both intervention groups aimed for equivalent weight loss (6-7%) following a calorie-restricted diet (diet group) or a partly supervised intensive exercise programme (4 h per week) combined with a small caloric restriction (exercise plus diet group). Outcomes after 16 weeks are amount and distribution of abdominal fat, measured by magnetic resonance imaging (MRI) with the use of the three-point IDEAL Dixon method. Results: The diet and exercise plus diet group lost 6.1 and 6.9% body weight, respectively. Compared to controls, subcutaneous and intra-abdominal fat reduced significantly with both diet (- 12.5% and - 12.0%) and exercise plus diet (- 16.0% and - 14.6%). Direct comparison between both interventions revealed that the reduction in subcutaneous fat was statistically significantly larger in the group that combined exercise with diet: an additional 10.6 cm 2 (95%CI -18.7; - 2.4) was lost compared to the diet-only group. Intra-abdominal fat loss was not significantly larger in the exercise plus diet group (- 3.8 cm 2 , 95%CI -9.0; 1.3). Conclusions: We conclude that weight loss of 6-7% with diet or with exercise plus diet reduced both subcutaneous and intra-abdominal fat. Only subcutaneous fat statistically significantly reduced to a larger extent when exercise is combined with a small caloric restriction. Trial register: NCT01511276 (clinicaltrials.gov), prospectively registered.

AB - Background: We assessed the effect of equivalent weight loss with or without exercise on (intra-) abdominal fat in postmenopausal women in the SHAPE-2 study. Methods: The SHAPE-2 study is a three-armed randomised controlled trial conducted in 2012-2013 in the Netherlands. Postmenopausal overweight women were randomized to a diet (n = 97), exercise plus diet (n = 98) or control group (n = 48). Both intervention groups aimed for equivalent weight loss (6-7%) following a calorie-restricted diet (diet group) or a partly supervised intensive exercise programme (4 h per week) combined with a small caloric restriction (exercise plus diet group). Outcomes after 16 weeks are amount and distribution of abdominal fat, measured by magnetic resonance imaging (MRI) with the use of the three-point IDEAL Dixon method. Results: The diet and exercise plus diet group lost 6.1 and 6.9% body weight, respectively. Compared to controls, subcutaneous and intra-abdominal fat reduced significantly with both diet (- 12.5% and - 12.0%) and exercise plus diet (- 16.0% and - 14.6%). Direct comparison between both interventions revealed that the reduction in subcutaneous fat was statistically significantly larger in the group that combined exercise with diet: an additional 10.6 cm 2 (95%CI -18.7; - 2.4) was lost compared to the diet-only group. Intra-abdominal fat loss was not significantly larger in the exercise plus diet group (- 3.8 cm 2 , 95%CI -9.0; 1.3). Conclusions: We conclude that weight loss of 6-7% with diet or with exercise plus diet reduced both subcutaneous and intra-abdominal fat. Only subcutaneous fat statistically significantly reduced to a larger extent when exercise is combined with a small caloric restriction. Trial register: NCT01511276 (clinicaltrials.gov), prospectively registered.

KW - Exercise

KW - Intra-abdominal fat

KW - Subcutaneous fat

KW - Weight loss

UR - http://www.scopus.com/inward/record.url?scp=85061351877&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85061351877&partnerID=8YFLogxK

U2 - 10.1186/s12889-019-6510-1

DO - 10.1186/s12889-019-6510-1

M3 - Article

VL - 19

SP - 1

EP - 9

JO - BMC Public Health

JF - BMC Public Health

SN - 1471-2458

M1 - 174

ER -

Van Gemert WA, Peeters PH, May AM, Doornbos AJH, Elias SG, Van Der Palen J et al. Effect of diet with or without exercise on abdominal fat in postmenopausal women - A randomised trial. BMC Public Health. 2019 Feb 11;19:1-9. 174. https://doi.org/10.1186/s12889-019-6510-1