Effect of dimethly sulfoxide (DMSO) on the electrocardiogram (ECG) in freely moving male Balb/c mice.

K. Kramer; S.A.B.E. van Acker; J.A. Grimbergen; D.J. van den Berg; W.J.F. van der Vijgh; A. Bast

doi:10.1016/0306-3623(94)00300-C

Effect of dimethly sulfoxide (DMSO) on the electrocardiogram (ECG) in freely moving male Balb/c mice.

K. Kramer, S.A.B.E. van Acker, J.A. Grimbergen, D.J. van den Berg, W.J.F. van der Vijgh, A. Bast

Medicinal chemistry

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

1. 1. Since dimethyl sulfoxide (DMSO) is a solvent which is often used for drugs in animal studies, we investigated the effect of a daily administration of DMSO on the telemetrically obtained electrocardiogram (ECG) in freely moving male Balb/c mice. 2. 2. During treatment with 4.5 ml 100% DMSO/kg i.p. 5 days per week during 3 weeks, DMSO caused substantial cardiotoxicity. The ST-interval increased significantly after 1 week by 2.2 ± 1.3 msec and also the ECG wave form changed completely in time. 3. 3. During treatment with 4.5 ml 50% DMSO/kg i.p. 5 days per week during 3 weeks, no significant difference was observed compared with the control animals. 4. 4. During the entire study the maximal heart rate and body weight remained constant in all treated groups. 5. 5. The data indicate that DMSO can not be used in a 100% concentration to dissolve compounds that are tested for protection against the cardiotoxicity of cytostatics. © 1995.

Original language	English
Pages (from-to)	1403-1407
Journal	General Pharmacology
Volume	26
DOIs	https://doi.org/10.1016/0306-3623(94)00300-C
Publication status	Published - 1995

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title = "Effect of dimethly sulfoxide (DMSO) on the electrocardiogram (ECG) in freely moving male Balb/c mice.",

abstract = "1. 1. Since dimethyl sulfoxide (DMSO) is a solvent which is often used for drugs in animal studies, we investigated the effect of a daily administration of DMSO on the telemetrically obtained electrocardiogram (ECG) in freely moving male Balb/c mice. 2. 2. During treatment with 4.5 ml 100% DMSO/kg i.p. 5 days per week during 3 weeks, DMSO caused substantial cardiotoxicity. The ST-interval increased significantly after 1 week by 2.2 ± 1.3 msec and also the ECG wave form changed completely in time. 3. 3. During treatment with 4.5 ml 50% DMSO/kg i.p. 5 days per week during 3 weeks, no significant difference was observed compared with the control animals. 4. 4. During the entire study the maximal heart rate and body weight remained constant in all treated groups. 5. 5. The data indicate that DMSO can not be used in a 100% concentration to dissolve compounds that are tested for protection against the cardiotoxicity of cytostatics. {\textcopyright} 1995.",

author = "K. Kramer and {van Acker}, S.A.B.E. and J.A. Grimbergen and {van den Berg}, D.J. and {van der Vijgh}, W.J.F. and A. Bast",

year = "1995",

doi = "10.1016/0306-3623(94)00300-C",

language = "English",

volume = "26",

pages = "1403--1407",

journal = "General Pharmacology",

issn = "0306-3623",

publisher = "Elsevier BV",

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TY - JOUR

T1 - Effect of dimethly sulfoxide (DMSO) on the electrocardiogram (ECG) in freely moving male Balb/c mice.

AU - Kramer, K.

AU - van Acker, S.A.B.E.

AU - Grimbergen, J.A.

AU - van den Berg, D.J.

AU - van der Vijgh, W.J.F.

AU - Bast, A.

PY - 1995

Y1 - 1995

N2 - 1. 1. Since dimethyl sulfoxide (DMSO) is a solvent which is often used for drugs in animal studies, we investigated the effect of a daily administration of DMSO on the telemetrically obtained electrocardiogram (ECG) in freely moving male Balb/c mice. 2. 2. During treatment with 4.5 ml 100% DMSO/kg i.p. 5 days per week during 3 weeks, DMSO caused substantial cardiotoxicity. The ST-interval increased significantly after 1 week by 2.2 ± 1.3 msec and also the ECG wave form changed completely in time. 3. 3. During treatment with 4.5 ml 50% DMSO/kg i.p. 5 days per week during 3 weeks, no significant difference was observed compared with the control animals. 4. 4. During the entire study the maximal heart rate and body weight remained constant in all treated groups. 5. 5. The data indicate that DMSO can not be used in a 100% concentration to dissolve compounds that are tested for protection against the cardiotoxicity of cytostatics. © 1995.

AB - 1. 1. Since dimethyl sulfoxide (DMSO) is a solvent which is often used for drugs in animal studies, we investigated the effect of a daily administration of DMSO on the telemetrically obtained electrocardiogram (ECG) in freely moving male Balb/c mice. 2. 2. During treatment with 4.5 ml 100% DMSO/kg i.p. 5 days per week during 3 weeks, DMSO caused substantial cardiotoxicity. The ST-interval increased significantly after 1 week by 2.2 ± 1.3 msec and also the ECG wave form changed completely in time. 3. 3. During treatment with 4.5 ml 50% DMSO/kg i.p. 5 days per week during 3 weeks, no significant difference was observed compared with the control animals. 4. 4. During the entire study the maximal heart rate and body weight remained constant in all treated groups. 5. 5. The data indicate that DMSO can not be used in a 100% concentration to dissolve compounds that are tested for protection against the cardiotoxicity of cytostatics. © 1995.

U2 - 10.1016/0306-3623(94)00300-C

DO - 10.1016/0306-3623(94)00300-C

M3 - Article

VL - 26

SP - 1403

EP - 1407

JO - General Pharmacology

JF - General Pharmacology

SN - 0306-3623

ER -

Effect of dimethly sulfoxide (DMSO) on the electrocardiogram (ECG) in freely moving male Balb/c mice.

Abstract

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