Effect of n-3 fatty acids from fish on electrocardiographic characteristics in patients with frequent premature ventricular complexes

Anouk Geelen*, Peter L Zock, Ingeborg A. Brouwer, Martijn B. Katan, Jan A. Kors, Henk J Ritsema Van Eck, Evert G. Schouten

*Corresponding author for this work

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

n-3 Fatty acids may protect against heart disease mortality by preventing fatal arrhythmias. Underlying effects on cardiac electrophysiology may be demonstrable in the standard electrocardiogram (ECG) and provide insight into the mechanism. Therefore, we investigated the effect of dietary n-3 fatty acids on heart-rate-corrected QT interval, T-loop width, spatial QRS-T angle and spatial U-wave amplitude in patients with frequent premature ventricular complexes. Seventy-four patients received either capsules providing 1.5 g n-3 fatty acids daily or placebo for approximately 14 weeks. ECG were recorded before and after intervention. None of the ECG characteristics was significantly affected by treatment. The present results do not provide additional support for the hypothesis that n-3 fatty acids prevent cardiac arrhythmia through generic electrophysiologic effects on heart cell membranes. However, we cannot exclude effects of n-3 fatty acids on clinical relevant endpoints that are not easily detected by prior changes in the ECG.

Original languageEnglish
Pages (from-to)787-790
Number of pages4
JournalBritish Journal of Nutrition
Volume93
Issue number6
DOIs
Publication statusPublished - 2005
Externally publishedYes

Keywords

  • Electrocardiogram
  • Electrophysiology
  • Heart-rate-corrected QT interval
  • n-3 Fatty acids

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