Effect of periodontal therapy with systemic antimicrobials on parameters of metabolic syndrome: A randomized clinical trial

S. Bizzarro; U. van der Velden; W.J. Teeuw; V.E.A. Gerdes; B.G. Loos

doi:10.1111/jcpe.12763

Effect of periodontal therapy with systemic antimicrobials on parameters of metabolic syndrome: A randomized clinical trial

S. Bizzarro, U. van der Velden, W.J. Teeuw, V.E.A. Gerdes, B.G. Loos

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

Aim: To investigate the effect of basic periodontal therapy (BPT) with antimicrobials (AM) on the parameters of metabolic syndrome (MetS) (waist circumference, systolic/diastolic blood pressure [BP], HDL- cholesterol, triglycerides, glucose).

Methods: One hundred and ten periodontitis patients without known comorbidities and unaware of possible MetS were randomly assigned to BPT (n = 56) or BPT+AM (n = 54) and followed for 12 months post-therapy. Number of patients with undiagnosed MetS was also determined.

Results: In all patients, the periodontal condition improved; however, the BTP+AM group showed greater pocket depth reduction than the BPT group. Post-therapy, sys-tolic BP (p < .05) and triglycerides (p < .05) reduced significantly during the follow-up period. No significant differences could be assessed between the BPT+AM and BPT group. Despite the absence of self reported comorbidities, 27.2% (n = 30) periodontitis patients fulfilled the criteria of MetS at baseline. After therapy, this proportion changed to 14.5% at 3 months (p = .007), to 17.3% at 6 months (p = .017) and to 21.8% at 12-month follow- up (p = .383).

Conclusion: Although a reduction in systolic BP and triglycerides and a temporarily improvement in the whole metabolic status were observed, the use of antimicrobials in conjunction with BTP does not yield any additional improvement in the parameters of MetS.

Original language	English
Pages (from-to)	833-841
Number of pages	9
Journal	Journal of Clinical Periodontology
Volume	44
Issue number	8
DOIs	https://doi.org/10.1111/jcpe.12763
Publication status	Published - Aug 2017

Bibliographical note

Clinical trial registration number: ISRCTN36043780

Funding

Funding information This study was funded by several sources: by the authors' institution, by an unconditional grant from Philips Oral Healthcare, by a grant from the University of Amsterdam for the focal point “Oral Infection and Inflammation” and by a grant from the Dutch Society of Periodontology (NVvP). Clinical trial registration number: ISRCTN36043780 (Current Controlled Trials)

Funders	Funder number
Dutch Society of Periodontology
NVVP	ISRCTN36043780
Philips Oral Healthcare
Universiteit van Amsterdam

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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https://hdl.handle.net/11245.1/0c50f9a6-c399-4c79-bb15-2d40465a1e40

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Cite this

@article{f3a7205c88c048f0adafbf7230ae88d0,

title = "Effect of periodontal therapy with systemic antimicrobials on parameters of metabolic syndrome: A randomized clinical trial",

abstract = "Aim: To investigate the effect of basic periodontal therapy (BPT) with antimicrobials (AM) on the parameters of metabolic syndrome (MetS) (waist circumference, systolic/diastolic blood pressure [BP], HDL- cholesterol, triglycerides, glucose).Methods: One hundred and ten periodontitis patients without known comorbidities and unaware of possible MetS were randomly assigned to BPT (n = 56) or BPT+AM (n = 54) and followed for 12 months post-therapy. Number of patients with undiagnosed MetS was also determined.Results: In all patients, the periodontal condition improved; however, the BTP+AM group showed greater pocket depth reduction than the BPT group. Post-therapy, sys-tolic BP (p < .05) and triglycerides (p < .05) reduced significantly during the follow-up period. No significant differences could be assessed between the BPT+AM and BPT group. Despite the absence of self reported comorbidities, 27.2% (n = 30) periodontitis patients fulfilled the criteria of MetS at baseline. After therapy, this proportion changed to 14.5% at 3 months (p = .007), to 17.3% at 6 months (p = .017) and to 21.8% at 12-month follow- up (p = .383).Conclusion: Although a reduction in systolic BP and triglycerides and a temporarily improvement in the whole metabolic status were observed, the use of antimicrobials in conjunction with BTP does not yield any additional improvement in the parameters of MetS.",

author = "S. Bizzarro and {van der Velden}, U. and W.J. Teeuw and V.E.A. Gerdes and B.G. Loos",

note = "Clinical trial registration number: ISRCTN36043780",

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doi = "10.1111/jcpe.12763",

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volume = "44",

pages = "833--841",

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publisher = "Blackwell Munksgaard",

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T1 - Effect of periodontal therapy with systemic antimicrobials on parameters of metabolic syndrome

T2 - A randomized clinical trial

AU - Bizzarro, S.

AU - van der Velden, U.

AU - Teeuw, W.J.

AU - Gerdes, V.E.A.

AU - Loos, B.G.

N1 - Clinical trial registration number: ISRCTN36043780

PY - 2017/8

Y1 - 2017/8

N2 - Aim: To investigate the effect of basic periodontal therapy (BPT) with antimicrobials (AM) on the parameters of metabolic syndrome (MetS) (waist circumference, systolic/diastolic blood pressure [BP], HDL- cholesterol, triglycerides, glucose).Methods: One hundred and ten periodontitis patients without known comorbidities and unaware of possible MetS were randomly assigned to BPT (n = 56) or BPT+AM (n = 54) and followed for 12 months post-therapy. Number of patients with undiagnosed MetS was also determined.Results: In all patients, the periodontal condition improved; however, the BTP+AM group showed greater pocket depth reduction than the BPT group. Post-therapy, sys-tolic BP (p < .05) and triglycerides (p < .05) reduced significantly during the follow-up period. No significant differences could be assessed between the BPT+AM and BPT group. Despite the absence of self reported comorbidities, 27.2% (n = 30) periodontitis patients fulfilled the criteria of MetS at baseline. After therapy, this proportion changed to 14.5% at 3 months (p = .007), to 17.3% at 6 months (p = .017) and to 21.8% at 12-month follow- up (p = .383).Conclusion: Although a reduction in systolic BP and triglycerides and a temporarily improvement in the whole metabolic status were observed, the use of antimicrobials in conjunction with BTP does not yield any additional improvement in the parameters of MetS.

AB - Aim: To investigate the effect of basic periodontal therapy (BPT) with antimicrobials (AM) on the parameters of metabolic syndrome (MetS) (waist circumference, systolic/diastolic blood pressure [BP], HDL- cholesterol, triglycerides, glucose).Methods: One hundred and ten periodontitis patients without known comorbidities and unaware of possible MetS were randomly assigned to BPT (n = 56) or BPT+AM (n = 54) and followed for 12 months post-therapy. Number of patients with undiagnosed MetS was also determined.Results: In all patients, the periodontal condition improved; however, the BTP+AM group showed greater pocket depth reduction than the BPT group. Post-therapy, sys-tolic BP (p < .05) and triglycerides (p < .05) reduced significantly during the follow-up period. No significant differences could be assessed between the BPT+AM and BPT group. Despite the absence of self reported comorbidities, 27.2% (n = 30) periodontitis patients fulfilled the criteria of MetS at baseline. After therapy, this proportion changed to 14.5% at 3 months (p = .007), to 17.3% at 6 months (p = .017) and to 21.8% at 12-month follow- up (p = .383).Conclusion: Although a reduction in systolic BP and triglycerides and a temporarily improvement in the whole metabolic status were observed, the use of antimicrobials in conjunction with BTP does not yield any additional improvement in the parameters of MetS.

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DO - 10.1111/jcpe.12763

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SP - 833

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JO - Journal of Clinical Periodontology

JF - Journal of Clinical Periodontology

IS - 8

ER -

Effect of periodontal therapy with systemic antimicrobials on parameters of metabolic syndrome: A randomized clinical trial

Abstract

Bibliographical note

Funding

UN SDGs

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