Effect of Vitamin B-12 and Folic Acid Supplementation on Bone Mineral Density and Quantitative Ultrasound Parameters in Older People with an Elevated Plasma Homocysteine Level: B-PROOF, a Randomized Controlled Trial

A.W. Enneman; C.M.A. Swart; J.P. van Wijngaarden; S.C. van Dijk; A.C. van der Ham; E.M. Brouwer-Brolsma; N.L. van der Zwaluw; R.A.M. Dhonukshe-Rutten; T.J.M. van der Cammen; L.C.P.G. de Groot; J. van Meurs; P. Lips; A. G. Uitterlinden; M.C. Zillikens; N.M. van Schoor; N. van der Velde

doi:10.1007/s00223-015-9968-6

Effect of Vitamin B-12 and Folic Acid Supplementation on Bone Mineral Density and Quantitative Ultrasound Parameters in Older People with an Elevated Plasma Homocysteine Level: B-PROOF, a Randomized Controlled Trial

A.W. Enneman
, C.M.A. Swart
, J.P. van Wijngaarden
, S.C. van Dijk
, A.C. van der Ham
, E.M. Brouwer-Brolsma
, N.L. van der Zwaluw
, R.A.M. Dhonukshe-Rutten
, T.J.M. van der Cammen
, L.C.P.G. de Groot
, J. van Meurs
, P. Lips
, A. G. Uitterlinden
, M.C. Zillikens
, N.M. van Schoor
, N. van der Velde

Research output: Contribution to Journal › Article › Academic › peer-review

Abstract

High plasma homocysteine (Hcy) levels are associated with increased osteoporotic fracture incidence. However, the mechanism remains unclear. We investigated the effect of Hcy-lowering vitamin B

Original language	English
Pages (from-to)	401-409
Journal	Calcified Tissue International
Volume	96
Issue number	5
DOIs	https://doi.org/10.1007/s00223-015-9968-6
Publication status	Published - 2015

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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Enneman, A. W., Swart, C. M. A., van Wijngaarden, J. P., van Dijk, S. C., van der Ham, A. C., Brouwer-Brolsma, E. M., van der Zwaluw, N. L., Dhonukshe-Rutten, R. A. M., van der Cammen, T. J. M., de Groot, L. C. P. G., van Meurs, J., Lips, P., Uitterlinden, A. G., Zillikens, M. C., van Schoor, N. M., & van der Velde, N. (2015). Effect of Vitamin B-12 and Folic Acid Supplementation on Bone Mineral Density and Quantitative Ultrasound Parameters in Older People with an Elevated Plasma Homocysteine Level: B-PROOF, a Randomized Controlled Trial. Calcified Tissue International, 96(5), 401-409. https://doi.org/10.1007/s00223-015-9968-6

@article{448beb8640b94ac6a90f164578cfadda,

title = "Effect of Vitamin B-12 and Folic Acid Supplementation on Bone Mineral Density and Quantitative Ultrasound Parameters in Older People with an Elevated Plasma Homocysteine Level: B-PROOF, a Randomized Controlled Trial",

abstract = "High plasma homocysteine (Hcy) levels are associated with increased osteoporotic fracture incidence. However, the mechanism remains unclear. We investigated the effect of Hcy-lowering vitamin B",

author = "A.W. Enneman and C.M.A. Swart and \{van Wijngaarden\}, J.P. and \{van Dijk\}, S.C. and \{van der Ham\}, A.C. and E.M. Brouwer-Brolsma and \{van der Zwaluw\}, N.L. and R.A.M. Dhonukshe-Rutten and \{van der Cammen\}, T.J.M. and \{de Groot\}, L.C.P.G. and \{van Meurs\}, J. and P. Lips and Uitterlinden, \{A. G.\} and M.C. Zillikens and \{van Schoor\}, N.M. and \{van der Velde\}, N.",

year = "2015",

doi = "10.1007/s00223-015-9968-6",

language = "English",

volume = "96",

pages = "401--409",

journal = "Calcified Tissue International",

issn = "0171-967X",

publisher = "Springer",

number = "5",

}

Enneman, AW, Swart, CMA, van Wijngaarden, JP, van Dijk, SC, van der Ham, AC, Brouwer-Brolsma, EM, van der Zwaluw, NL, Dhonukshe-Rutten, RAM, van der Cammen, TJM, de Groot, LCPG, van Meurs, J, Lips, P, Uitterlinden, AG, Zillikens, MC, van Schoor, NM & van der Velde, N 2015, 'Effect of Vitamin B-12 and Folic Acid Supplementation on Bone Mineral Density and Quantitative Ultrasound Parameters in Older People with an Elevated Plasma Homocysteine Level: B-PROOF, a Randomized Controlled Trial', Calcified Tissue International, vol. 96, no. 5, pp. 401-409. https://doi.org/10.1007/s00223-015-9968-6

Effect of Vitamin B-12 and Folic Acid Supplementation on Bone Mineral Density and Quantitative Ultrasound Parameters in Older People with an Elevated Plasma Homocysteine Level: B-PROOF, a Randomized Controlled Trial. / Enneman, A.W.; Swart, C.M.A.; van Wijngaarden, J.P. et al.
In: Calcified Tissue International, Vol. 96, No. 5, 2015, p. 401-409.

Research output: Contribution to Journal › Article › Academic › peer-review

TY - JOUR

T1 - Effect of Vitamin B-12 and Folic Acid Supplementation on Bone Mineral Density and Quantitative Ultrasound Parameters in Older People with an Elevated Plasma Homocysteine Level: B-PROOF, a Randomized Controlled Trial

AU - Enneman, A.W.

AU - Swart, C.M.A.

AU - van Wijngaarden, J.P.

AU - van Dijk, S.C.

AU - van der Ham, A.C.

AU - Brouwer-Brolsma, E.M.

AU - van der Zwaluw, N.L.

AU - Dhonukshe-Rutten, R.A.M.

AU - van der Cammen, T.J.M.

AU - de Groot, L.C.P.G.

AU - van Meurs, J.

AU - Lips, P.

AU - Uitterlinden, A. G.

AU - Zillikens, M.C.

AU - van Schoor, N.M.

AU - van der Velde, N.

PY - 2015

Y1 - 2015

N2 - High plasma homocysteine (Hcy) levels are associated with increased osteoporotic fracture incidence. However, the mechanism remains unclear. We investigated the effect of Hcy-lowering vitamin B

AB - High plasma homocysteine (Hcy) levels are associated with increased osteoporotic fracture incidence. However, the mechanism remains unclear. We investigated the effect of Hcy-lowering vitamin B

U2 - 10.1007/s00223-015-9968-6

DO - 10.1007/s00223-015-9968-6

M3 - Article

SN - 0171-967X

VL - 96

SP - 401

EP - 409

JO - Calcified Tissue International

JF - Calcified Tissue International

IS - 5

ER -

Enneman AW, Swart CMA, van Wijngaarden JP, van Dijk SC, van der Ham AC, Brouwer-Brolsma EM et al. Effect of Vitamin B-12 and Folic Acid Supplementation on Bone Mineral Density and Quantitative Ultrasound Parameters in Older People with an Elevated Plasma Homocysteine Level: B-PROOF, a Randomized Controlled Trial. Calcified Tissue International. 2015;96(5):401-409. doi: 10.1007/s00223-015-9968-6