Effectiveness of internet-and mobile-based cognitive behavioral therapy to reduce suicidal ideation and behaviors: Protocol for a systematic review and meta-analysis of individual participant data

Rebekka Büscher*, Marie Beisemann, Philipp Doebler, Lena Steubl, Matthias Domhardt, Pim Cuijpers, Ad Kerkhof, Lasse B. Sander

*Corresponding author for this work

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Internet-and mobile-based cognitive behavioral therapy (iCBT) might reduce suicidal ideation. However, recent meta-analyses found small effect sizes, and it remains unclear whether specific subgroups of participants experience beneficial or harmful effects. This is the study protocol for an individual participant meta-analysis (IPD-MA) aiming to determine the effectiveness of iCBT on suicidal ideation and identify moderators. We will systematically search CENTRAL, PsycINFO, Embase, and Pubmed for randomized controlled trials examining guided or self-guided iCBT for suicidality. All types of control conditions are eligible. Participants experiencing suicidal ideation will be included irrespective of age, diagnoses, or co-interventions. We will conduct a one-stage IPD-MA with suicidal ideation as the primary outcome, using a continuous measure, reliable improvement and deterioration, and response rate. Moderator analyses will be performed on participant-, study-, and intervention-level. Two independent reviewers will assess risk of bias and the quality of evidence using Cochrane’s Risk of Bias Tool 2 and GRADE. This review was registered with OSF and is currently in progress. The IPD-MA will provide effect estimates while considering covariates and will offer novel insights into differential effects on a participant level. This will help to develop more effective, safe, and tailored digital treatment options for suicidal individuals.

Original languageEnglish
Article number5179
Pages (from-to)1-11
Number of pages11
JournalInternational Journal of Environmental Research and Public Health
Volume17
Issue number14
DOIs
Publication statusPublished - 2 Jul 2020

Keywords

  • Cognitive behavioral therapy
  • ICBT
  • Individual participant data meta-analysis
  • Internet-based
  • Mobile-based
  • Online
  • Review
  • Suicidal ideation
  • Suicide

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