Abstract
Objective: This individual patient data (IPD) meta-analysis aimed to evaluate the effects of psychosocial interventions (PSI) on quality of life (QoL), emotional function (EF), and social function (SF) in patients with cancer, and to study moderator effects of demographic, clinical, personal, and intervention-related characteristics. Methods: Relevant studies were identified via literature searches in 4 databases. We pooled IPD from 22 (n = 4217) of 61 eligible randomized controlled trials. Linear mixed-effect model analyses were used to study intervention effects on the post-intervention values of QoL, EF, and SF (z-scores), adjusting for baseline values, age, and cancer type. We studied moderator effects by testing interactions with the intervention for demographic, clinical, personal, and intervention-related characteristics, and conducted subsequent stratified analyses for significant moderator variables.Results: PSI significantly improved QoL (β = 0.14,95%CI = 0.06;0.21), EF (β = 0.13,95%CI = 0.05;0.20), and SF (β = 0.10,95%CI = 0.03;0.18). Significant differences in effects of different types of PSI were found, with largest effects of psychotherapy. The effects of coping skills training were moderated by age, treatment type, and targeted interventions. Effects of psychotherapy on EF may be moderated by cancer type, but these analyses were based on 2 randomized controlled trials with small sample sizes of some cancer types. Conclusions: PSI significantly improved QoL, EF, and SF, with small overall effects. However, the effects differed by several demographic, clinical, personal, and intervention-related characteristics. Our study highlights the beneficial effects of coping skills training in patients treated with chemotherapy, the importance of targeted interventions, and the need of developing interventions tailored to the specific needs of elderly patients.
Original language | English |
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Pages (from-to) | 1150-1161 |
Number of pages | 12 |
Journal | Psycho-Oncology |
Volume | 27 |
Issue number | 4 |
Early online date | 23 Jan 2018 |
DOIs | |
Publication status | Published - Apr 2018 |
Bibliographical note
This article is protected by copyright. All rights reserved.Funding
The POLARIS study was supported by the “Bas Mulder Award” granted to L.M. Buffart by the Alpe d'HuZes foundation, part of the Dutch Cancer Society (VU 2011‐5045).
Funders | Funder number |
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Alpe d'HuZes foundation | |
Dutch Cancer Society | VU 2011‐5045 |
L.M. | |
KWF Kankerbestrijding |
Keywords
- coping skills training
- individual patient data meta-analysis
- neoplasm
- psychosocial care
- psychotherapy
- quality of life