Effects of 5-HT on memory and the hippocampus: model and data.

M. Meeter, L.M. Talamini, J.A.J. Schmitt, W.J. Riedel

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5-Hydroxytryptamine (5-HT) transmission has been implicated in memory and in depression. Both 5-HT depletion and specific 5-HT agonists lower memory performance, while depression is also associated with memory deficits. The precise neuropharmacology and neural mechanisms underlying these effects are unknown. We used neural network simulations to elucidate the neuropharmacology and network mechanisms underlying 5-HT effects on memory. The model predicts that these effects are largely dependent on transmission over the 5-HT
Original languageEnglish
Pages (from-to)712-720
Number of pages10
Publication statusPublished - 2006


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