Effects of 5-HT on memory and the hippocampus: model and data.

M. Meeter; L.M. Talamini; J.A.J. Schmitt; W.J. Riedel

doi:10.1038/sj.npp.1300869

Effects of 5-HT on memory and the hippocampus: model and data.

M. Meeter
, L.M. Talamini
, J.A.J. Schmitt
, W.J. Riedel

Cognitive Psychology

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Abstract

5-Hydroxytryptamine (5-HT) transmission has been implicated in memory and in depression. Both 5-HT depletion and specific 5-HT agonists lower memory performance, while depression is also associated with memory deficits. The precise neuropharmacology and neural mechanisms underlying these effects are unknown. We used neural network simulations to elucidate the neuropharmacology and network mechanisms underlying 5-HT effects on memory. The model predicts that these effects are largely dependent on transmission over the 5-HT

Original language	English
Pages (from-to)	712-720
Number of pages	10
Journal	Neuropsychopharmacology
Volume	31
DOIs	https://doi.org/10.1038/sj.npp.1300869
Publication status	Published - 2006

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Meeter Neuropsychopharmacology 31 2006 uFinal published version, 239 KB

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Effects of 5-HT on memory and the hippocampus: model and data.

Abstract

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