Abstract
Aim: To study effects of advanced platelet rich Fibrin (A-PRF+) and enamel matrix derivative (EMD) compared to open flap debridement (OFD) alone in molar furcation sites grade II on clinical and wound healing parameters. Materials and methods: A randomized controlled trial was designed. Eligible patients were randomly allocated in one of three treatment groups: A-PRF+, EMD or OFD. The patients and clinical examiners were blinded for the treatment received. A minimally invasive microsurgical approach was performed for the three modalities. Clinical measurements were scored at baseline and 6 months postoperatively. The clinical healing of each furcation was scored via Early Wound Healing Index on day 3, 1 week, 2 weeks and 6 weeks. Results: 17 patients (A-PRF+ n = 6, EMD n = 5, OFD n = 6) completed the 6 months follow-up. The further completion of the trial had to be cancelled due to the COVID-19 pandemic. In three patients in the A-PRF+ group, the grade II of the treated furcation regressed to grade I; the corresponding number in the EMD and OFD groups were zero and one respectively. Further, 3, 1 and 4 patients in the PRF, EMD and OFD groups respectively, showed a gain of bone level ≥1 mm. The defects in the A-PRF+ group showed delayed early healing compared to EMD and OFD groups. Conclusion: The case series (RCT design) suggest a slight advantage for A-PRF+ over EMD and OFD, regarding the regressing of a furcation II to grade I, however this treatment showed delayed early wound healing compared to EMD or OFD. Clinical Trial Registration: https://www.isrctn.com/, identifier ISRCTN13520922.
Original language | English |
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Article number | 1223217 |
Pages (from-to) | 1-13 |
Number of pages | 13 |
Journal | Frontiers in Dental Medicine |
Volume | 4 |
DOIs | |
Publication status | Published - 31 Jul 2023 |
Bibliographical note
Funding Information:The authors do not have any financial interests, either directly or indirectly, in the products or information presented in the paper. The study was entirely financed by the Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), Amsterdam, The Netherlands.
Publisher Copyright:
2023 Pitzurra, Vadravellis, Rosema, Bizzarro and Loos.
Keywords
- amelogenin (Emdogain)
- furcation defect
- periodontal reconstruction
- periodontal surgery
- PRF (platelet-rich fibrin)