TY - JOUR
T1 - Effects of an attachment-based intervention on daily cortisol moderated by dopamine receptor D4
T2 - A randomized control trial on 1- to 3-year-olds screened for externalizing behavior
AU - Bakermans-Kranenburg, Marian J.
AU - Van Ijzendoorn, Marinus H.
AU - Mesman, Judi
AU - Alink, Lenneke R.A.
AU - Juffer, Femmie
PY - 2008/6/1
Y1 - 2008/6/1
N2 - The effect of the Video-Feedback Intervention to Promote Positive Parenting and Sensitive Discipline (VIPP-SD) on daily cortisol production was tested in a randomized controlled trial with 130 families with 1- to 3-year-old children screened for their relatively high levels of externalizing behavior. Six 1.5-hr intervention sessions focusing on maternal sensitivity and discipline were conducted with individual families at their homes. Children in the intervention group showed lower cortisol levels, with a moderating role of the dopamine receptor D4 (DRD4) VNTR exon III polymorphism. The VIPP-SD program proved to be effective in decreasing daily cortisol production in children with the DRD4 7-repeat allele, but not in children without the DRD4 7-repeat allele. Our findings indicate that children are differentially susceptible to intervention effects dependent on the presence of the 7-repeat DRD4 allele.
AB - The effect of the Video-Feedback Intervention to Promote Positive Parenting and Sensitive Discipline (VIPP-SD) on daily cortisol production was tested in a randomized controlled trial with 130 families with 1- to 3-year-old children screened for their relatively high levels of externalizing behavior. Six 1.5-hr intervention sessions focusing on maternal sensitivity and discipline were conducted with individual families at their homes. Children in the intervention group showed lower cortisol levels, with a moderating role of the dopamine receptor D4 (DRD4) VNTR exon III polymorphism. The VIPP-SD program proved to be effective in decreasing daily cortisol production in children with the DRD4 7-repeat allele, but not in children without the DRD4 7-repeat allele. Our findings indicate that children are differentially susceptible to intervention effects dependent on the presence of the 7-repeat DRD4 allele.
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U2 - 10.1017/S0954579408000382
DO - 10.1017/S0954579408000382
M3 - Article
C2 - 18606032
AN - SCOPUS:48949116393
SN - 0954-5794
VL - 20
SP - 805
EP - 820
JO - Development and Psychopathology
JF - Development and Psychopathology
IS - 3
ER -