Effects of attachment-based compassion therapy (ABCT) on brain-derived neurotrophic factor and low-grade inflammation among fibromyalgia patients: A randomized controlled trial

Jesus Montero-Marin, Laura Andrés-Rodríguez, Mattie Tops, Juan V. Luciano, Mayte Navarro-Gil, Albert Feliu-Soler, Yolanda López-del-Hoyo, Javier Garcia-Campayo

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Fibromyalgia (FM) is a disabling syndrome characterized by chronic pain associated with fatigue. Its pathogenesis is unknown, but alterations in central sensitization, involving an imbalance of brain-derived neurotrophic factor (BDNF) and inflammatory biomarkers, appear to be implicated. The aim of this study was to evaluate the impact of attachment-based compassion therapy (ABCT) on levels of BDNF, the inflammatory markers TNF-α, IL-6, IL-10, and the C-reactive protein (CRP), analysing whether biomarkers play a mediating/moderating role in improvements in FM functional status. Thirty-four female patients with FM participated in a RCT and were assigned to ABCT or relaxation therapy. Blood extractions were conducted at baseline and post-intervention, with self-report assessments of functional status (FIQ) at baseline, post-intervention and 3-month follow-up. A pro-inflammatory composite was obtained by summing up IL-6, TNF-α and CRP normalized values. Non-parametric tests, analysis of variance and regression models were used to evaluate treatment and mediation/moderation. Compared to relaxation therapy, ABCT showed significant improvements in FIQ and decreases in BDNF, CRP, and pro-inflammatory composite. Changes in BDNF had a mediating role in FIQ. ABCT seems to reduce BDNF and appears to have anti-inflammatory effects in FM patients. Reductions in BDNF could be a mechanism of FM functional status improvement. Clinical Trial Registration:http://ClinicalTrials.gov, identifier NCT02454244. Date: May 27th, 2015.

Original languageEnglish
Article number15639
Pages (from-to)1-14
Number of pages14
JournalScientific Reports
Volume9
Issue number1
Early online date30 Oct 2019
DOIs
Publication statusPublished - 1 Dec 2019

Fingerprint

Fibromyalgia
Brain-Derived Neurotrophic Factor
Randomized Controlled Trials
Inflammation
C-Reactive Protein
Relaxation Therapy
Interleukin-6
Therapeutics
Biomarkers
Central Nervous System Sensitization
Chronic Pain
Interleukin-10
Self Report
Fatigue
Analysis of Variance
Anti-Inflammatory Agents
Clinical Trials

Cite this

Montero-Marin, J., Andrés-Rodríguez, L., Tops, M., Luciano, J. V., Navarro-Gil, M., Feliu-Soler, A., ... Garcia-Campayo, J. (2019). Effects of attachment-based compassion therapy (ABCT) on brain-derived neurotrophic factor and low-grade inflammation among fibromyalgia patients: A randomized controlled trial. Scientific Reports, 9(1), 1-14. [15639]. https://doi.org/10.1038/s41598-019-52260-z
Montero-Marin, Jesus ; Andrés-Rodríguez, Laura ; Tops, Mattie ; Luciano, Juan V. ; Navarro-Gil, Mayte ; Feliu-Soler, Albert ; López-del-Hoyo, Yolanda ; Garcia-Campayo, Javier. / Effects of attachment-based compassion therapy (ABCT) on brain-derived neurotrophic factor and low-grade inflammation among fibromyalgia patients : A randomized controlled trial. In: Scientific Reports. 2019 ; Vol. 9, No. 1. pp. 1-14.
@article{4e2258ce7dcb4ff29c10e84bb3110e32,
title = "Effects of attachment-based compassion therapy (ABCT) on brain-derived neurotrophic factor and low-grade inflammation among fibromyalgia patients: A randomized controlled trial",
abstract = "Fibromyalgia (FM) is a disabling syndrome characterized by chronic pain associated with fatigue. Its pathogenesis is unknown, but alterations in central sensitization, involving an imbalance of brain-derived neurotrophic factor (BDNF) and inflammatory biomarkers, appear to be implicated. The aim of this study was to evaluate the impact of attachment-based compassion therapy (ABCT) on levels of BDNF, the inflammatory markers TNF-α, IL-6, IL-10, and the C-reactive protein (CRP), analysing whether biomarkers play a mediating/moderating role in improvements in FM functional status. Thirty-four female patients with FM participated in a RCT and were assigned to ABCT or relaxation therapy. Blood extractions were conducted at baseline and post-intervention, with self-report assessments of functional status (FIQ) at baseline, post-intervention and 3-month follow-up. A pro-inflammatory composite was obtained by summing up IL-6, TNF-α and CRP normalized values. Non-parametric tests, analysis of variance and regression models were used to evaluate treatment and mediation/moderation. Compared to relaxation therapy, ABCT showed significant improvements in FIQ and decreases in BDNF, CRP, and pro-inflammatory composite. Changes in BDNF had a mediating role in FIQ. ABCT seems to reduce BDNF and appears to have anti-inflammatory effects in FM patients. Reductions in BDNF could be a mechanism of FM functional status improvement. Clinical Trial Registration:http://ClinicalTrials.gov, identifier NCT02454244. Date: May 27th, 2015.",
author = "Jesus Montero-Marin and Laura Andr{\'e}s-Rodr{\'i}guez and Mattie Tops and Luciano, {Juan V.} and Mayte Navarro-Gil and Albert Feliu-Soler and Yolanda L{\'o}pez-del-Hoyo and Javier Garcia-Campayo",
year = "2019",
month = "12",
day = "1",
doi = "10.1038/s41598-019-52260-z",
language = "English",
volume = "9",
pages = "1--14",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

Montero-Marin, J, Andrés-Rodríguez, L, Tops, M, Luciano, JV, Navarro-Gil, M, Feliu-Soler, A, López-del-Hoyo, Y & Garcia-Campayo, J 2019, 'Effects of attachment-based compassion therapy (ABCT) on brain-derived neurotrophic factor and low-grade inflammation among fibromyalgia patients: A randomized controlled trial' Scientific Reports, vol. 9, no. 1, 15639, pp. 1-14. https://doi.org/10.1038/s41598-019-52260-z

Effects of attachment-based compassion therapy (ABCT) on brain-derived neurotrophic factor and low-grade inflammation among fibromyalgia patients : A randomized controlled trial. / Montero-Marin, Jesus; Andrés-Rodríguez, Laura; Tops, Mattie; Luciano, Juan V.; Navarro-Gil, Mayte; Feliu-Soler, Albert; López-del-Hoyo, Yolanda; Garcia-Campayo, Javier.

In: Scientific Reports, Vol. 9, No. 1, 15639, 01.12.2019, p. 1-14.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - Effects of attachment-based compassion therapy (ABCT) on brain-derived neurotrophic factor and low-grade inflammation among fibromyalgia patients

T2 - A randomized controlled trial

AU - Montero-Marin, Jesus

AU - Andrés-Rodríguez, Laura

AU - Tops, Mattie

AU - Luciano, Juan V.

AU - Navarro-Gil, Mayte

AU - Feliu-Soler, Albert

AU - López-del-Hoyo, Yolanda

AU - Garcia-Campayo, Javier

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Fibromyalgia (FM) is a disabling syndrome characterized by chronic pain associated with fatigue. Its pathogenesis is unknown, but alterations in central sensitization, involving an imbalance of brain-derived neurotrophic factor (BDNF) and inflammatory biomarkers, appear to be implicated. The aim of this study was to evaluate the impact of attachment-based compassion therapy (ABCT) on levels of BDNF, the inflammatory markers TNF-α, IL-6, IL-10, and the C-reactive protein (CRP), analysing whether biomarkers play a mediating/moderating role in improvements in FM functional status. Thirty-four female patients with FM participated in a RCT and were assigned to ABCT or relaxation therapy. Blood extractions were conducted at baseline and post-intervention, with self-report assessments of functional status (FIQ) at baseline, post-intervention and 3-month follow-up. A pro-inflammatory composite was obtained by summing up IL-6, TNF-α and CRP normalized values. Non-parametric tests, analysis of variance and regression models were used to evaluate treatment and mediation/moderation. Compared to relaxation therapy, ABCT showed significant improvements in FIQ and decreases in BDNF, CRP, and pro-inflammatory composite. Changes in BDNF had a mediating role in FIQ. ABCT seems to reduce BDNF and appears to have anti-inflammatory effects in FM patients. Reductions in BDNF could be a mechanism of FM functional status improvement. Clinical Trial Registration:http://ClinicalTrials.gov, identifier NCT02454244. Date: May 27th, 2015.

AB - Fibromyalgia (FM) is a disabling syndrome characterized by chronic pain associated with fatigue. Its pathogenesis is unknown, but alterations in central sensitization, involving an imbalance of brain-derived neurotrophic factor (BDNF) and inflammatory biomarkers, appear to be implicated. The aim of this study was to evaluate the impact of attachment-based compassion therapy (ABCT) on levels of BDNF, the inflammatory markers TNF-α, IL-6, IL-10, and the C-reactive protein (CRP), analysing whether biomarkers play a mediating/moderating role in improvements in FM functional status. Thirty-four female patients with FM participated in a RCT and were assigned to ABCT or relaxation therapy. Blood extractions were conducted at baseline and post-intervention, with self-report assessments of functional status (FIQ) at baseline, post-intervention and 3-month follow-up. A pro-inflammatory composite was obtained by summing up IL-6, TNF-α and CRP normalized values. Non-parametric tests, analysis of variance and regression models were used to evaluate treatment and mediation/moderation. Compared to relaxation therapy, ABCT showed significant improvements in FIQ and decreases in BDNF, CRP, and pro-inflammatory composite. Changes in BDNF had a mediating role in FIQ. ABCT seems to reduce BDNF and appears to have anti-inflammatory effects in FM patients. Reductions in BDNF could be a mechanism of FM functional status improvement. Clinical Trial Registration:http://ClinicalTrials.gov, identifier NCT02454244. Date: May 27th, 2015.

UR - http://www.scopus.com/inward/record.url?scp=85074277713&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85074277713&partnerID=8YFLogxK

U2 - 10.1038/s41598-019-52260-z

DO - 10.1038/s41598-019-52260-z

M3 - Article

VL - 9

SP - 1

EP - 14

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 15639

ER -