Effects of clonidine and scopolamine on multiple target detection in rapid serial visual presentation

Stephen B.R.E. Brown*, Heleen A. Slagter, Martijn S. Van Noorden, Erik J. Giltay, Nic J.A. Van Der Wee, Sander Nieuwenhuis

*Corresponding author for this work

Research output: Contribution to JournalArticleAcademicpeer-review


Rationale: The specific role of neuromodulator systems in regulating rapid fluctuations of attention is still poorly understood. Objectives: In this study, we examined the effects of clonidine and scopolamine on multiple target detection in a rapid serial visual presentation task to assess the role of the central noradrenergic and cholinergic systems in temporal attention. Method: Eighteen healthy volunteers took part in a crossover double-dummy study in which they received clonidine (150/175 μg), scopolamine (1.2 mg), and placebo by mouth in counterbalanced order. A dual-target attentional blink task was administered at 120 min after scopolamine intake and 180 min after clonidine intake. The electroencephalogram was measured during task performance. Results: Clonidine and scopolamine both impaired detection of the first target (T1). For clonidine, this impairment was accompanied by decreased amplitudes of the P2 and P3 components of the event-related potential. The drugs did not impair second-target (T2) detection, except if T2 was presented immediately after T1. The attentional blink for T2 was not affected, in line with a previous study that found no effect of clonidine on the attentional blink. Conclusions: These and other results suggest that clonidine and scopolamine may impair temporal attention through a decrease in tonic alertness and that this decrease in alertness can be temporarily compensated by a phasic alerting response to a salient stimulus. The comparable behavioral effects of clonidine and scopolamine are consistent with animal studies indicating close interactions between the noradrenergic and cholinergic neuromodulator systems.

Original languageEnglish
Pages (from-to)341-350
Number of pages10
Issue number2
Publication statusPublished - 1 Jan 2016
Externally publishedYes


  • Acetylcholine
  • Attentional blink
  • Noradrenaline
  • Rapid serial visual presentation
  • Temporal attention


Dive into the research topics of 'Effects of clonidine and scopolamine on multiple target detection in rapid serial visual presentation'. Together they form a unique fingerprint.

Cite this