Effects of continuous positive airway pressure and mandibular advancement appliance therapy on sleep bruxism in adults with obstructive sleep apnea: a pilot study

Deshui Li*, Frank Lobbezoo, Boyuan Kuang, Antonius A.J. Hilgevoord, Nico de Vries, Ghizlane Aarab

*Corresponding author for this work

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Study objectives: This study aimed to investigate the effects of continuous positive airway pressure (CPAP) and mandibular advancement appliance (MAA) therapy on rhythmic masticatory muscle activity (RMMA), a biomarker of sleep bruxism (SB), and to compare the effects of CPAP with MAA in adults with obstructive sleep apnea (OSA). Methods: This cohort study included individuals with OSA who received treatment with CPAP or MAA. Polysomnographic recordings with and without therapy were performed in each individual. Statistical analyses were performed with repeated measures ANOVA. Results: A total of 38 individuals with OSA were enrolled, 13 on CPAP and 25 with MAA, mean age 52.6 ± 10.6 years, 32 men, mean baseline apnea-hypopnea index (AHI) 26.5 ± 15.2 events/hour, mean RMMA index 3.5 ±events/hour. In the total group, the RMMA index decreased significantly with CPAP and MAA therapies (P < 0.05). The changes in the RMMA index with therapy did not differ significantly between CPAP and MAA (P > 0.05). The RMMA index decreased in 60% of the individuals with OSA, and the changes ranged widely, with a median of 52% and an interquartile range of 107%. Conclusions: Both CPAP and MAA therapies significantly reduce SB in individuals with OSA. However, the interindividual differences in the effects of these therapies on SB are large. Clinical Trial Registration:https://trialsearch.who.int

Original languageEnglish
Pages (from-to)1857-1864
Number of pages8
JournalSleep and breathing
Volume27
Issue number5
Early online date3 Mar 2023
DOIs
Publication statusPublished - Oct 2023

Bibliographical note

Funding Information:
The authors thank Annemieke van der Klink, Naziha Siallioui, and other staff of the Department of Clinical Neurophysiology, OLVG, Amsterdam, The Netherlands, for their assistance with the data collection of this work. Thanks to Naichuan Su and Irene Aartman for their suggestions on the statistical analyses of this study. Deshui Li and Boyuan Kuang acknowledges the support from the China scholarship council (CSC), China. The grant has no role in the conception, design, and execution of this study.

Funding Information:
The authors thank Annemieke van der Klink, Naziha Siallioui, and other staff of the Department of Clinical Neurophysiology, OLVG, Amsterdam, The Netherlands, for their assistance with the data collection of this work. Thanks to Naichuan Su and Irene Aartman for their suggestions on the statistical analyses of this study. Deshui Li and Boyuan Kuang acknowledges the support from the China scholarship council (CSC), China. The grant has no role in the conception, design, and execution of this study.

Publisher Copyright:
© 2023, The Author(s).

Keywords

  • Continuous positive airway pressure
  • Mandibular advancement appliance
  • Obstructive sleep apnea
  • Polysomnography
  • Sleep bruxism

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