Effects of early social deprivation on epigenetic statuses and adaptive behavior of young children: A study based on a cohort of institutionalized infants and toddlers

Oxana Yu Naumova, Sergey Yu Rychkov, Sergey A. Kornilov, Veronika V. Odintsova, Varvara O. Anikina, Maria Yu Solodunova, Irina A. Arintcina, Marina A. Zhukova, Irina V. Ovchinnikova, Olga V. Burenkova, Olga V. Zhukova, Rifkat J. Muhamedrahimov, Elena L. Grigorenko

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

Early social deprivation (i.e., an insufficiency or lack of parental care) has been identified as a significant adverse early experience that may affect multiple facets of child development and cause long-term outcomes in physical and mental health, cognition and behavior. Current research provides growing evidence that epigenetic reprogramming may be a mechanism modulating these effects of early adversities. This work aimed to investigate the impact of early institutionalization—the immersion in an extreme socially depriving environment in humans—on the epigenome and adaptive behavior of young children up to 4 years of age. We conducted a cross-sectional study involving two comparison groups: 29 children raised in orphanages and 29 children raised in biological families. Genome-wide DNA methylation profiles of blood cells were obtained using the Illumina MethylationEPIC array; the level of child adaptive functioning was assessed using the Vineland Adaptive Behavior Scales-II. In comparison to children raised in families, children residing in orphanages had both statistically significant deficits in multiple adaptive behavior domains and statistically significant differences in DNA methylation states. Moreover, some of these methylation states may directly modulate the behavioral deficits; according to preliminary estimates, about 7–14% of the deviation of adaptive behavior between groups of children may be determined by their difference in DNA methylation profiles. The duration of institutionalization had a significant impact on both the adaptive level and DNA methylation status of institutionalized children.

Original languageEnglish
Article numbere0214285
Pages (from-to)1-29
Number of pages29
JournalPLoS ONE
Volume14
Issue number3
DOIs
Publication statusPublished - 26 Mar 2019

Fingerprint

toddlers
Psychological Adaptation
Epigenomics
epigenetics
DNA Methylation
DNA methylation
Orphanages
Methylation
Institutionalized Child
Blood
Genes
Cells
Health
Institutionalization
child development
mental health
Immersion
Child Development
Cognition
blood cells

Cite this

Naumova, Oxana Yu ; Rychkov, Sergey Yu ; Kornilov, Sergey A. ; Odintsova, Veronika V. ; Anikina, Varvara O. ; Solodunova, Maria Yu ; Arintcina, Irina A. ; Zhukova, Marina A. ; Ovchinnikova, Irina V. ; Burenkova, Olga V. ; Zhukova, Olga V. ; Muhamedrahimov, Rifkat J. ; Grigorenko, Elena L. / Effects of early social deprivation on epigenetic statuses and adaptive behavior of young children : A study based on a cohort of institutionalized infants and toddlers. In: PLoS ONE. 2019 ; Vol. 14, No. 3. pp. 1-29.
@article{308c4b9c4491434f8842db844bc1f5cd,
title = "Effects of early social deprivation on epigenetic statuses and adaptive behavior of young children: A study based on a cohort of institutionalized infants and toddlers",
abstract = "Early social deprivation (i.e., an insufficiency or lack of parental care) has been identified as a significant adverse early experience that may affect multiple facets of child development and cause long-term outcomes in physical and mental health, cognition and behavior. Current research provides growing evidence that epigenetic reprogramming may be a mechanism modulating these effects of early adversities. This work aimed to investigate the impact of early institutionalization—the immersion in an extreme socially depriving environment in humans—on the epigenome and adaptive behavior of young children up to 4 years of age. We conducted a cross-sectional study involving two comparison groups: 29 children raised in orphanages and 29 children raised in biological families. Genome-wide DNA methylation profiles of blood cells were obtained using the Illumina MethylationEPIC array; the level of child adaptive functioning was assessed using the Vineland Adaptive Behavior Scales-II. In comparison to children raised in families, children residing in orphanages had both statistically significant deficits in multiple adaptive behavior domains and statistically significant differences in DNA methylation states. Moreover, some of these methylation states may directly modulate the behavioral deficits; according to preliminary estimates, about 7–14{\%} of the deviation of adaptive behavior between groups of children may be determined by their difference in DNA methylation profiles. The duration of institutionalization had a significant impact on both the adaptive level and DNA methylation status of institutionalized children.",
author = "Naumova, {Oxana Yu} and Rychkov, {Sergey Yu} and Kornilov, {Sergey A.} and Odintsova, {Veronika V.} and Anikina, {Varvara O.} and Solodunova, {Maria Yu} and Arintcina, {Irina A.} and Zhukova, {Marina A.} and Ovchinnikova, {Irina V.} and Burenkova, {Olga V.} and Zhukova, {Olga V.} and Muhamedrahimov, {Rifkat J.} and Grigorenko, {Elena L.}",
year = "2019",
month = "3",
day = "26",
doi = "10.1371/journal.pone.0214285",
language = "English",
volume = "14",
pages = "1--29",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "3",

}

Naumova, OY, Rychkov, SY, Kornilov, SA, Odintsova, VV, Anikina, VO, Solodunova, MY, Arintcina, IA, Zhukova, MA, Ovchinnikova, IV, Burenkova, OV, Zhukova, OV, Muhamedrahimov, RJ & Grigorenko, EL 2019, 'Effects of early social deprivation on epigenetic statuses and adaptive behavior of young children: A study based on a cohort of institutionalized infants and toddlers' PLoS ONE, vol. 14, no. 3, e0214285, pp. 1-29. https://doi.org/10.1371/journal.pone.0214285

Effects of early social deprivation on epigenetic statuses and adaptive behavior of young children : A study based on a cohort of institutionalized infants and toddlers. / Naumova, Oxana Yu; Rychkov, Sergey Yu; Kornilov, Sergey A.; Odintsova, Veronika V.; Anikina, Varvara O.; Solodunova, Maria Yu; Arintcina, Irina A.; Zhukova, Marina A.; Ovchinnikova, Irina V.; Burenkova, Olga V.; Zhukova, Olga V.; Muhamedrahimov, Rifkat J.; Grigorenko, Elena L.

In: PLoS ONE, Vol. 14, No. 3, e0214285, 26.03.2019, p. 1-29.

Research output: Contribution to JournalArticleAcademicpeer-review

TY - JOUR

T1 - Effects of early social deprivation on epigenetic statuses and adaptive behavior of young children

T2 - A study based on a cohort of institutionalized infants and toddlers

AU - Naumova, Oxana Yu

AU - Rychkov, Sergey Yu

AU - Kornilov, Sergey A.

AU - Odintsova, Veronika V.

AU - Anikina, Varvara O.

AU - Solodunova, Maria Yu

AU - Arintcina, Irina A.

AU - Zhukova, Marina A.

AU - Ovchinnikova, Irina V.

AU - Burenkova, Olga V.

AU - Zhukova, Olga V.

AU - Muhamedrahimov, Rifkat J.

AU - Grigorenko, Elena L.

PY - 2019/3/26

Y1 - 2019/3/26

N2 - Early social deprivation (i.e., an insufficiency or lack of parental care) has been identified as a significant adverse early experience that may affect multiple facets of child development and cause long-term outcomes in physical and mental health, cognition and behavior. Current research provides growing evidence that epigenetic reprogramming may be a mechanism modulating these effects of early adversities. This work aimed to investigate the impact of early institutionalization—the immersion in an extreme socially depriving environment in humans—on the epigenome and adaptive behavior of young children up to 4 years of age. We conducted a cross-sectional study involving two comparison groups: 29 children raised in orphanages and 29 children raised in biological families. Genome-wide DNA methylation profiles of blood cells were obtained using the Illumina MethylationEPIC array; the level of child adaptive functioning was assessed using the Vineland Adaptive Behavior Scales-II. In comparison to children raised in families, children residing in orphanages had both statistically significant deficits in multiple adaptive behavior domains and statistically significant differences in DNA methylation states. Moreover, some of these methylation states may directly modulate the behavioral deficits; according to preliminary estimates, about 7–14% of the deviation of adaptive behavior between groups of children may be determined by their difference in DNA methylation profiles. The duration of institutionalization had a significant impact on both the adaptive level and DNA methylation status of institutionalized children.

AB - Early social deprivation (i.e., an insufficiency or lack of parental care) has been identified as a significant adverse early experience that may affect multiple facets of child development and cause long-term outcomes in physical and mental health, cognition and behavior. Current research provides growing evidence that epigenetic reprogramming may be a mechanism modulating these effects of early adversities. This work aimed to investigate the impact of early institutionalization—the immersion in an extreme socially depriving environment in humans—on the epigenome and adaptive behavior of young children up to 4 years of age. We conducted a cross-sectional study involving two comparison groups: 29 children raised in orphanages and 29 children raised in biological families. Genome-wide DNA methylation profiles of blood cells were obtained using the Illumina MethylationEPIC array; the level of child adaptive functioning was assessed using the Vineland Adaptive Behavior Scales-II. In comparison to children raised in families, children residing in orphanages had both statistically significant deficits in multiple adaptive behavior domains and statistically significant differences in DNA methylation states. Moreover, some of these methylation states may directly modulate the behavioral deficits; according to preliminary estimates, about 7–14% of the deviation of adaptive behavior between groups of children may be determined by their difference in DNA methylation profiles. The duration of institutionalization had a significant impact on both the adaptive level and DNA methylation status of institutionalized children.

UR - http://www.scopus.com/inward/record.url?scp=85063508441&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85063508441&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0214285

DO - 10.1371/journal.pone.0214285

M3 - Article

VL - 14

SP - 1

EP - 29

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 3

M1 - e0214285

ER -