Abstract
Objectives
The aim of the present study was to measure the effects of a 5,000-ppm F toothpaste on caries-related factors in dental plaque and saliva.
Materials and methods
A 6-week clinical trial was designed with a total of 34 participants, of which 26 completed the study. The participants were assessed on four visits, 2 weeks apart. Sampling of approximal fluid for fluoride analysis and approximal plaque for organic acid analysis was performed. Chair-side tests were performed to register the lactic acid production rate on the tongue using Clinpro™ Cario L-Pop™, approximal plaque pH using the pH "strip method" and salivary buffer capacity and counts of cariogenic microorganisms using CRT Buffer® and CRT Bacteria®.
Results
Six weeks’ use of 5,000-ppm fluoridated (F) toothpaste significantly increased the approximal fluid F concentration (p < 0.05). There was a significant decrease in lactic acid production rate on the tongue assessed by Clinpro™ (p < 0.05). This was accompanied by changes in interproximal plaque acidogenicity, including significant reductions in AUC5.7, AUC6.2 and maximum pH fall and an increase in minimum pH (p < 0.05). A significant increase in the salivary buffer capacity and a reduction in the salivary mutans streptococci were observed (p < 0.05).
Conclusion
The present study demonstrates the ability of 5,000-ppm F toothpaste to modify caries-related factors in dental plaque and saliva.
Clinical relevance
The 5,000-ppm F toothpaste could be regarded as a possible effective regimen against caries in the near future.
The aim of the present study was to measure the effects of a 5,000-ppm F toothpaste on caries-related factors in dental plaque and saliva.
Materials and methods
A 6-week clinical trial was designed with a total of 34 participants, of which 26 completed the study. The participants were assessed on four visits, 2 weeks apart. Sampling of approximal fluid for fluoride analysis and approximal plaque for organic acid analysis was performed. Chair-side tests were performed to register the lactic acid production rate on the tongue using Clinpro™ Cario L-Pop™, approximal plaque pH using the pH "strip method" and salivary buffer capacity and counts of cariogenic microorganisms using CRT Buffer® and CRT Bacteria®.
Results
Six weeks’ use of 5,000-ppm fluoridated (F) toothpaste significantly increased the approximal fluid F concentration (p < 0.05). There was a significant decrease in lactic acid production rate on the tongue assessed by Clinpro™ (p < 0.05). This was accompanied by changes in interproximal plaque acidogenicity, including significant reductions in AUC5.7, AUC6.2 and maximum pH fall and an increase in minimum pH (p < 0.05). A significant increase in the salivary buffer capacity and a reduction in the salivary mutans streptococci were observed (p < 0.05).
Conclusion
The present study demonstrates the ability of 5,000-ppm F toothpaste to modify caries-related factors in dental plaque and saliva.
Clinical relevance
The 5,000-ppm F toothpaste could be regarded as a possible effective regimen against caries in the near future.
| Original language | English |
|---|---|
| Pages (from-to) | 1419-1426 |
| Journal | Clinical Oral Investigations |
| Volume | 18 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2014 |